Background: Telerehabilitation (TR) enables equitable access to therapeutic care over a distance; however, there is still a level of uncertainty about its efficiency in comparison with the traditional methods. Perception of patients has been inconclusive with aspects of technology use, quality care provision, and the satisfaction of patients with TR services being raised as issues to be investigated further. A systematic synthesis of patient experience is needed to establish TR’s general implications on health and well-being. Hence, the aim of this study is to review perceptions and experiences of clients on telerehabilitation. Methods: A systematic review of qualitative studies was conducted using eight electronic databases from inception to February 2026. Data were synthesized and the Critical Appraisal Skills Programme (CASP) tool was employed to assess quality of included studies. Results: The search strategy identified a total of 1667 articles and after removing duplicates and excluding articles based on title and abstract, and full text screening, 26 studies were included. Four major themes were developed: enhanced accessibility and reduced burden, perceived efficiency and continuity of care, therapeutic relationship and social presence, and digital and contextual challenges. Conclusions: Telerehabilitation reshapes rehabilitation delivery rather than merely adding technology. Its effectiveness depends on alignment among patient capability, clinical needs, and organizational support. When supported by adequate infrastructure and relational adaptation, it can enhance access and continuity and contribute to inclusive health delivery. However, if digital and contextual barriers remain unaddressed, telerehabilitation may inadvertently reinforce existing inequities.