Nucleic acids theoretically possess a Szilard engine function that can convert the energy associated with the Shannon entropy of molecules for which they have coded recognition, into the useful work of geometric reconfiguration of the nucleic acid molecule. This function is logically reversible because its mechanism is literally and physically constructed out of the information necessary to reduce the Shannon entropy of such molecules, which means that this information exists on both sides of the theoretical engine, and because information is retained in the geometric degrees of freedom of the nucleic acid molecule, a quantum gate is formed through which multi‐state nucleic acid qubits can interact. Entangled biophotons emitted as a consequence of symmetry breaking nucleic acid Szilard engine (NASE) function can be used to coordinate relative positioning of different nucleic acid locations, both within and between cells, thus providing the potential for quantum coherence of an entire biological system. Theoretical implications of understanding biological systems as such “quantum adaptive systems” include the potential for multi‐agent based quantum computing, and a better understanding of systemic pathologies such as cancer, as being related to a loss of systemic quantum coherence.

For a hundred years violation or surmounting the Quantum Uncertainty Principle has remained a Holy Grail of both theoretical and empirical physics. Utilizing an operationally completed form of Quantum Theory cast in a string theoretic Higher Dimensional (HD) form of Dirac covariant polarized vacuum with a complex Einstein energy dependent spacetime metric, ${\mathrm{M̂}}_4{\mathrm{\pm C}}_4$ with sufficient degrees of freedom to be causally free of the local quantum state, we present a simple empirical model for ontologically surmounting the phenomenology of uncertainty through a Sagnac Effect RF pulsed Laser Oscillated Vacuum Energy Resonance hierarchy cast within an extended form of a Wheeler‐Feynman‐Cramer Transactional Calabi‐Yau mirror symmetric spacetime bachcloth.

Generally unicellular prokaryotes are considered the most fundamental form of living system. Many researchers include viruses since they commandeer cellular machinery in their replication; while others insist viruses are merely complex infective proteins. New biological principles are introduced suggesting that even the prion, the infectious protein responsible for transmissible spongiform encephalopathies, qualifies as the most fundamental form of life; and remains in general concordance with the six‐point definition of living systems put forth by Humberto Maturana and his colleagues in their original characterization of living organisms as a class of complex self‐organized autopoietic systems in 1974.

Newton claimed instantaneous G-influence; Einstein insisted no influence propagated faster than c. Quantum Mechanics (QM) the so-called basement of reality, posits a Quantum Gravity, for which no a priori science exists. We propose a paradigm shift with duality between a semi-quantum Standard Model (SM) limit and Large-Scale Additional Dimensionality (LSXD) in a modified M-Theoretic Unified Field (UF) brane arena as the regime of integration described by an Ontological-Phase Topological Field Theory (OPTFT) requiring fundamental changes in the concept of dimensionality and matter. OPTFT is developed to formally describe 3^rd regime Unified Field Mechanics (UFM) (classical-Quantum-UFM) to relate Newton-Einstein duality by added degrees of freedom in a semiquantum limit enabling topological Dirac-Majorana doublet fusion supervening the uncertainty principle.