To investigate the health risks of particulate matter during spring dust storms in Beijing, this study selected atmospheric particulate samples collected during a typical dust storm event in March 2021. The DNA damage rates induced by PM_2.5 and PM₁₀ were measured using the Plasmid Scission Assay (PSA) and were used as an indicator of their oxidative potential. Water-soluble heavy metal elements (WSHM) in the samples were analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results indicate that due to the influence of the dust storm, the monthly average PM_2.5 mass concentration in March 2021 reached as high as 83 μg/m³, which could potentially raise the difficulty of air pollution control. It was found that during the dust storm event, PM_2.5 induced a higher DNA damage rate (mean 42.35% at an experimental dose of 200 μg/mL in the PSA) than PM₁₀ (mean 40.46% under the same experimental dosage). The DNA damage rates of dust storm particles showed a positive correlation trend (r = 0.60) with total WSHM concentrations. Exposure toxicity, calculated by multiplying the DNA damage rates under certain experimental PM doses by the PM mass concentrations, showed that the exposure risk of PM_2.5 during dust storms even exceeded that of PM_2.5 during haze events. This study reveals the potential toxicity and health risks associated with PM during dust storms, which calls for increased attention.