Vaccine hesitancy was one of the ten major threats to global health in 2019, according to the World Health Organisation. Nowadays, social media has an important role in the spread of information, misinformation, and disinformation about vaccines. Monitoring vaccine-related conversations on social media could help us to identify the factors that contribute to vaccine confidence in each historical period and geographical area. We used a hybrid approach to perform an opinion-mining analysis on 1,499,227 vaccine-related tweets published on Twitter from 1st June 2011 to 30th April 2019. Our algorithm classified 69.36% of the tweets as neutral, 21.78% as positive, and 8.86% as negative. The percentage of neutral tweets showed a decreasing tendency, while the proportion of positive and negative tweets increased over time. Peaks in positive tweets were observed every April. The proportion of positive tweets was significantly higher in the middle of the week and decreased during weekends. Negative tweets followed the opposite pattern. Among users with ≥2 tweets, 91.83% had a homogeneous polarised discourse. Positive tweets were more prevalent in Switzerland (71.43%). Negative tweets were most common in the Netherlands (15.53%), Canada (11.32%), Japan (10.74%), and the United States (10.49%). Opinion mining is potentially useful to monitor online vaccine-related concerns and adapt vaccine promotion strategies accordingly.

Background: Invasive meningococcal disease (IMD) caused by Neisseria meningitidis remains a major public health concern due to its severity, lethality, and long-term sequelae. To address the rise in serogroups W and Y in Spain, the Community of Madrid implemented a catch-up campaign in 2019–2021, targeting adolescents (ages 13–18) alongside routine tetravalent meningococcus vaccine (MenACWY) at age 12. This study evaluated MenACWY catch-up vaccination uptake in routine practice by describing vaccine coverage, temporal trends, and associated factors in adolescents born between 2001 and 2006. Methods: A population-based cross-sectional study was conducted using data from the Community of Madrid’s vaccination registry (SISPAL Vacunas). Vaccination coverage was calculated for adolescents with at least one recorded MenACWY dose from age 10 onwards. Temporal trends were analyzed by birth cohort and calendar time, and multivariable logistic regression models were used to identify factors associated with vaccination uptake. Results: Among 424,059 adolescents, overall vaccination coverage by December 2021 was 63.8%, ranging from 54.4% to 78.2% across birth cohorts. Coverage was highest in the 2006 cohort, likely due to co-administration with the tetanus and diphtheria (Td) booster. A slightly higher uptake was observed among females and adolescents with chronic conditions, while foreign-born adolescents consistently showed lower coverage. COVID-19 disruptions led to temporal variability, with sharp declines during lockdowns and partial recoveries thereafter, with persistent sociodemographic differences in uptake. Conclusions: By December 2021, coverage was incomplete, with marked variability across birth cohorts. Higher uptake was observed when vaccination was integrated into routine visits, while persistent sociodemographic disparities remained evident. These observational findings are consistent with the programmatic value of combined catch-up and routine strategies and the need for targeted actions to ensure equitable MenACWY coverage.

Las drogas de abuso alteran el estado de ánimo, percepción y funcionamiento, generando dependencia y síndrome de abstinencia. En España, el consumo de drogas ilegales es un problema de salud pública. Factores socioeconómicos, el nivel educativo de los progenitores pueden influir en el consumo. Analizar el consumo de drogas en universitarios y su relación con edad, sexo y nivel educativo de los progenitores. Estudio observacional, descriptivo, transversal en estudiantes universitarios. Se aplicó una encuesta de salud para evaluar el consumo de sustancias y datos sociodemográficos. Se utilizó IBM-SPSS-25 para análisis estadístico. Se incluyeron 498 estudiantes (mediana de edad: 19 años; 68.7% mujeres). El 23% reportó consumo de drogas, siendo la marihuana la más frecuente (54.5%). Se hallaron diferencias significativas en el consumo de marihuana y hachís según el sexo, siendo mayor en hombres (p<0.001). El consumo de cocaína fue mayor en estudiantes de mayor edad (p=0.003). El consumo de marihuana se asoció con mayor nivel educativo materno, mientras que cocaína y benzodiacepinas fue más frecuente en estudiantes con progenitores de menor nivel educativo (p<0.05). El consumo de drogas en universitarios varía según sexo, edad y nivel educativo de progenitores. Es fundamental diseñar estrategias preventivas focalizadas.