Introduction: Models of nicotine dependence indicate the influence of impulsivity and affectivity in smoking behaviors. However, it is necessary that studies with higher ecological validity are carried out in order to elucidate how impulsivity and affectivity articulate to provoke tobacco craving. Objective: To evaluate the interaction effects of response inhibition and affectivity in tobacco craving. Method: The study was carried out with 90 smokers, who were divided into two groups, according to their performance on a parametric Go/No-Go task (higher and lower level of response inhibition). Cue-elicited craving was measured by physiologic responses and self-report, before and after a pleasant or unpleasant affectivity manipulation. Results: Moderation analysis suggests that response inhibition and unpleasant affect have combined effects in self-report and skin conductance related to tobacco craving. Response inhibition levels seem to increase tobacco craving, but they are independent of pleasant affect. Discussion and conclusions: Affectivity is a fundamental factor in comprehending the relationship between response inhibition and craving for tobacco. The unpleasant affect is one of the triggers for the desire to smoke, especially for those more impulsive individuals, which have an exaggerated perception of tobacco effect in alleviating unpleasant experiences. It is essential to train techniques to control negative affect stimuli, especially in those individuals with less capacity to inhibit responses.

Background and aims: Social media increasingly shapes body image by promoting often unattainable beauty ideals. Concurrently, targeted online marketing of image- and performance-enhancing drugs (IPEDs) exploits these vulnerabilities, intensifying anxiety and fostering maladaptive behaviours such as problematic usage of the internet (PUI), compulsive exercise, and IPEDs consumption. This study explores these behaviours across nine countries and examines how PUI, excessive exercise, and IPEDs use predict appearance anxiety, aiming to inform targeted prevention strategies for at-risk populations. Methods: A total of 3,514 participants from nine countries completed a web-based survey assessing sociodemographic data, appearance anxiety (AAI), problematic internet use (PIUQ-9), excessive exercise (EAI-R), and IPEDs intake. Results: Appearance-related anxiety was observed in 12% of the participants, with the highest prevalence in Mexico (20.7%), Japan (13.8%) and Italy (13.6%). Median PUI scores were highest in Mexico (22.57) and Singapore (21.59). Excessive exercise was reported by 3.6% with no significant country differences. IPEDs use was reported by 28.3% of the sample, with the highest rates in Japan (60.6%). Logistic regression analyses revealed that PUI, excessive exercise and IPEDs use were significant predictors of appearance-related anxiety. Discussion and conclusions: The strong associations between PUI, excessive exercise, IPEDs use, and appearance anxiety underscore the complex interplay between online exposure, body image concerns and mental health. Cross-country differences suggest that socio-cultural factors influence appearance-related anxiety. These findings highlight the need for culturally sensitive interventions and policy measures that address the impact of digital media on body image, particularly to protect vulnerable populations.

The main objective is to analyze the directionality and frequency of different offline and online psychological violence in young heterosexual couples, and to examine the degree of agreement of the partners in their perception and motives of their use of violence. 230 young couples completed the study. The average age was 19.27 for women (SD = 1.73; range 15-24) and 20.51 for men (SD = 2.83; range 16-28). The results showed a high prevalence of violence with the exception of direct online aggression. Frequency was low, and agreement was generally acceptable. There were significant differences between the violence reported by each member. Both partners reported a low self-perception of victims or aggressors, and a low perception of their abusive online behaviors as a form of violence. The main justifications were the same for members. These results could help explain the relationship between adherence to romantic love myths and psychological violence

Background and Objectives: The improper disposal of expired and unused medications (EUM) poses significant environmental and health risks. Discarding EUM in household trash or drains leads to accidental poisoning, illegal trade, and ecosystem contamination. These persistent compounds often resist wastewater treatment, disrupting ecological balance and contributing to antimicrobial resistance, thereby increasing morbidity and mortality rates. This study aims to analyze the knowledge, attitudes and practices (KAP) and related factors of the Mexican population regarding the disposal of EUM. Methods: A cross-sectional, descriptive, and correlational study was conducted via an online survey of adults (18+) from October 2021 to October 2024. Results: Among 6080 participants (95.4% aged 18–59; 65.8% women), a medium level of KAP was observed. Notably, 51.5% did not use specialized disposal containers, only 15.5% knew container locations, and 30.5% correctly identified expiration dates. Significant associations emerged: lower education levels correlated with poorer disposal knowledge, while health-related backgrounds and postgraduate studies linked to positive attitudes and adequate practices. Ordinal logistic regression revealed that being elderly, belonging to a high socioeconomic class, having lower education levels, and lacking health-related studies were significantly associated with poor KAP regarding EUM disposal. Conclusions: Inadequate pharmaceutical disposal in Mexico compromises environmental and public health. Addressing this requires reinforced regulations, professionalized pharmacies, and a comprehensive approach to bridge knowledge gaps. Integrating digital tools—like real-time mapping and QR labeling—with accessible take-back schemes is vital in mitigating hazards and uphold the One Health triad.

The influence of behavioral disinhibition may vary according to the way this parameter is assessed and in relation to different patterns of smoke. This study evaluated the influence of sex, different levels of addiction, nicotine deprivation and smoking patterns on behavioral disinhibition in smokers and nonsmokers. The sample of 180 participants from 18 to 30 years old were recruited to complete the Parametric Go/No-Go (PGNG) and Stop Signal Task (SST). The results identified that smokers have more difficulty inhibiting a prepotent response than nonsmokers in SST, but not with PGNG. Female nonsmokers presented shorter SSRT than male nonsmokers and smokers. Moderate to high nicotine dependence influenced the poor precision on no-go trials of PGNG. Future research should focus on training and/or medication approaches to improve behavioral disinhibition.

The predominance of expository teaching in pharmaceutical sciences, focused on theoretical and lecture-based methods, limits practical application and hinders understanding of biopharmaceutical processes such as bioavailability, bioequivalence, and dissolution—essential for ensuring drug efficacy, quality and safety. To address this challenge, BioSimuLab was developed as a pedagogical simulator that reproduces dissolution processes in accordance with NOM-177-SSA1, generating simulated data for reference and test drugs. This tool enables the analysis of dissolution profiles, application of statistical reasoning, and evaluation of bioequivalence through parameters such as the similarity factor (f2) and linear regression. By promoting discovery-based learning and evidence-driven decision-making, BioSimuLab enhances analytical, technical, and interpretive skills, strengthens understanding of pharmacokinetic principles, and bridges the gap between theory and professional practice in pharmaceutical sciences, aligning educational outcomes with professional competencies.