The health risks of PM_2.5-bound heavy metals have attracted extensive attention recently. In order to evaluate those deleterious effects on human health more accurately, and to propose proper measures to reduce health risks of air pollution, the conduction of a source-specific health risk assessment is necessary. Based on daily collected PM_2.5 samples at different functional sites during winter 2019 in a megacity Chongqing, China, combining source apportionment results from PMF and health risk assessment from the U.S. EPA, the source-specific health risks from PM_2.5-bound heavy metals were given. Six types of PM_2.5 sources have been identified, coal burning (25.5%), motor vehicles (22.8%), industrial emissions (20.5%), biomass burning (15.9%), dust (7.8%), and ship emissions (7.5%). Results showed that the total hazard quotient (HQ) was 0.32 and the total carcinogenic risks (CR) were 2.09 × 10⁻⁶ for children and 8.36 × 10⁻⁶ for adults, implying certain risks for local residents. Industrial emissions related with Cr posed both the highest carcinogenic risk and noncarcinogenic risk (contributing 25% CR and 36% HQ). Coal combustion (associated with Cr, As, and Mn) contributed 15.46% CR and 20.64% HQ, while biomass burning and motor vehicles shared 19.99% and 19.05% of the total CR, respectively. This work indicated that health risks of air pollution sources were the combined effects of the source contribution and chemical components. In order to control the health risks of PM_2.5 to the local residents, the priority of targeted emission sources should be adopted for industrial emissions, biomass burning, vehicle emissions, and coal combustion sources.

Phytophthora infestans, the causal agent of potato late blight, triggered the devastating Great Irish Famine that lasted from 1845 to 1852. Today, it is still the greatest threat to the potato yield. Ethylicin is a broad-spectrum biomimetic-fungicide. However, its application in the control of Phytophthora infestans is still unknown. In this study, we investigated the effects of ethylicin on Phytophthora infestans. We found that ethylicin inhibited the mycelial growth, sporulation capacity, spore germination and virulence of Phytophthora infestans. Furthermore, the integrated analysis of proteomics and metabolomics indicates that ethylicin may inhibit peptide or protein biosynthesis by suppressing both the ribosomal function and amino acid metabolism, causing an inhibitory effect on Phytophthora infestans. These observations indicate that ethylicin may be an anti-oomycete agent that can be used to control Phytophthora infestans.

Fine particulate matter (PM_2.5) poses a significant global environmental health threat and is closely associated with diseases across multiple organ systems. This review systematically summarizes the toxic effects and underlying mechanisms of PM_2.5 in the respiratory, cardiovascular, nervous, immune, endocrine, digestive, and genitourinary systems. Key pathogenic processes involve shared pathways such as oxidative stress, inflammatory responses, endoplasmic reticulum stress, autophagy, and apoptosis, along with the activation of system-specific signaling networks. The complex composition and notable spatiotemporal variability of PM_2.5 present challenges for assessing its health risks and clarifying its mechanisms. Moving forward, integrating multi-omics and molecular epidemiology approaches will be essential to unravel its multi-system pathogenic networks and support the development of effective intervention strategies.