This study aims to evaluate the epidemiological characteristics of mother-to-child transmission (MTCT) of HIV and identify the possible factors leading to infant HIV infection using a retrospective cohort study of early infant diagnosis (EID). Information on a total of 3,145 exposed infant–mother pairs was collected from the EID platform from July 2014 to December 2019. The MTCT rate was 2.1%. Spatial–temporal maps showed that rates varied by year and by region, with four districts (Baise, Guigang, Guilin, and Hechi) maintaining rates of >2.0% in 2019. The rate of antiretroviral therapy (ART) use was 94.4%, with a gradual increase in prescriptions of highly active ART (HAART) from 83.0% in 2014 to 92.4% in 2019. A majority of 99.5% of infants were receiving artificial feeding. Factors associated with MTCT were ART use (odds ratio [OR] = 0.065, confidence interval [95% CI] = 0.035–0.121) and artificial feeding (OR = 0.091, 95% CI = 0.018–0.452). HAART was more helpful in decreasing the risk of MTCT compared with monotherapy (OR = 0.115, 95% CI = 0.014–0.933). ART during the postpartum period correlated with an increased risk (OR = 11.579, 95% CI = 1.402–95.960) compared with use of ART during pregnancy. This study indicates that MTCT rate of HIV is decreasing meaningfully in Guangxi. Some areas still face challenges in elimination of MTCT and need further resources and interventions. Future program planning should take into consideration the fact that ART use—in particular the use of HAART or ART during pregnancy—and replacement feeding may contribute to the prevention of MTCT.

Objective: Currently, the prevalence of multidrug-resistant tuberculosis (MDR-TB) in childhood tuberculosis (TB) in Shandong, China remains unclear. We retrospectively conducted laboratory-based surveillance in a high TB burden district, to analyze the local prevalence of MDR-TB in childhood TB. Methods: We collected data, including microbiological results and demographic and disease information, using a questionnaire and medical records. We used the chi-squared test to compare the prevalence of MDR-TB in childhood TB between two periods: 2008 to 2013 and 2014 to 2018. Results: In Shandong, the prevalence of MDR-TB in childhood TB was low, at 5.6%. Between 2008-2013 and 2014-2018 among children with TB, the prevalence of MDR-TB remained unchanged, the proportion with pulmonary TB decreased from 78.3% to 64.9%, and the proportion with a TB contact history decreased from 20.5% to 9.9%. Conclusions: The prevalence of MDR-TB among childhood TB in Shandong, China was low and has remained stable over the past years. However, non-tuberculous mycobacterial diseases may be a new challenge in the management of suspected childhood TB.