Nien Xiang Tou

Dr. Nien Xiang Tou


Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2021 in Journal of the American Medical Directors Association
Verified
Journal Article
Closed access
PCPei Ling Choo
Pei Ling Choo
NTNien Xiang Tou
Nien Xiang Tou
BPBenedict Pang
Benedict Pang
LLLay Khoon Lau
Lay Khoon Lau
KJKhalid Abdul Jabbar
Khalid Abdul Jabbar
Shiou Liang WeeShiou Liang Wee
Shiou Liang Wee

26 August 2021 in PLOS ONE
Verified
Journal Article
Open access
PDF file
NTNien Xiang Tou
Nien Xiang Tou
Shiou Liang WeeShiou Liang Wee
Shiou Liang Wee
BPBenedict Pang
Benedict Pang
LLLay Khoon Lau
Lay Khoon Lau
KJKhalid Abdul Jabbar
Khalid Abdul Jabbar
TNTze-Pin Ng
Tze-Pin Ng
Background: Sarcopenia and obesity are reportedly associated with risk of cognitive decline, and sarcopenic obesity (SO) heightens the risk, but the evidence is sparse and inconclusive. This study aimed to examine the association between SO and cognitive impairment. Methods: A total of 542 community-dwelling adults aged between 21 and 90 years were recruited. All participants were assessed for body composition (dual X-ray absorptiometry), handgrip strength (HGS), gait speed (GS), and cognitive function (Repeatable Battery for the Assessment of Neuropsychological Status). Sarcopenia was defined by the presence of low appendicular lean mass index (ALMI) and low HGS or low GS according to the 2019 Asian Working Group for Sarcopenia criteria, and obesity was defined based on the upper two quintiles of fat mass index (FMI). Results: Sarcopenia alone or in combination with obesity were not significantly associated with cognitive impairment after controlling for confounding variables. Obesity on its own was significantly associated with greater odds of impaired attention (OR: 2.05, 95%CI 1.12–3.82). Low ALMI was not associated, but low HGS, slow GS, and high FMI were individually associated with cognitive impairment: low HGS and immediate memory (OR: 1.91, 95% CI 1.04–3.49); low GS and immediate memory (OR: 2.17, 95% CI 1.26–3.72); high FMI and attention (OR: 2.06, 95% CI 1.22–3.51). Co-occurring high FMI with either low HGS or slow GS exacerbated the observed odds of global and domain-specific (attention, visuospatial) cognitive impairment. Conclusions: Lean mass is not relevant, whereas muscle strength and physical performance or adiposity are relevant in defining sarcopenia or sarcopenic obesity in terms of their cognitive impacts.

10 October 2024 in European Review of Aging and Physical Activity
Verified
Journal Article
Open access
PDF file
NTNien Xiang Tou
Nien Xiang Tou
SGSiew Fong Goh
Siew Fong Goh
SHSusana Harding
Susana Harding
MTMary Ann Tsao
Mary Ann Tsao
TNTze Pin Ng
Tze Pin Ng
Shiou Liang WeeShiou Liang Wee
Shiou Liang Wee
Background: Due to poorer exercise tolerance, it may be challenging for frail older adults to engage in moderate- or vigorous-intensity exercise. While low-intensity exercise interventions may be more feasible, its effectiveness for such population group remains unclear. We examined the effectiveness and implementation of community-based Baduanjin Qigong, a low-intensity exercise program in older adults with varying frailty status. Methods: A two-arm, multicenter assessor-blind parallel group randomized controlled trial was conducted at three local senior activity centers. Fifty-six community-dwelling older adults with low handgrip strength were randomly allocated to either the intervention (IG) or wait-list control (CG) group. The IG underwent a supervised 16-week Baduanjin exercise program at a frequency of 2–3 × 60 min sessions/week. The CG was instructed to maintain their usual activity and received a monthly health education talk. The primary outcome measures were knee extension strength, vital exhaustion, and fear of falling. Secondary outcome measures include physiological falls risk, handgrip strength, gait speed, timed up and go test, 30-second sit-to-stand, quality of life, depression, and frailty. All outcome measures were assessed at baseline and 4-month follow-up. Results: Overall, there were no statistically significant differences in all outcome measures between CG and IG at 4-month follow-up. However, in exploratory compliance analysis, a statistically significant group x time interaction was found for vital exhaustion (B = -3.65, 95% CI [-7.13, -0.16], p = .047) among participants with at least 75% attendance. In post-hoc within-group comparisons, IG showed improved vital exhaustion by 4.31 points (95% CI [1.41, 7.20], d = 0.60). The average participant attendance rate was 81.3%. No major adverse events occurred, and all participants reported positive experiences with the exercise intervention. Conclusions: Our study demonstrated that Baduanjin is a safe, feasible, and acceptable exercise program that can be successfully implemented in community settings for older adults with varying frailty status. With good adherence, Baduanjin exercise could potentially be effective in alleviating vital exhaustion. However, the effectiveness of Baduanjin on physical performance, psychological measures and frailty in community-dwelling older adults remains equivocal. Trial registration: ClinicalTrials.gov NCT04549103. Registered September 16, 2020.

24 March 2023 in American Journal of Physical Medicine & Rehabilitation
Verified
Journal Article
Open access
LLLay Khoon Lau
Lay Khoon Lau
NTNien Xiang Tou
Nien Xiang Tou
KJKhalid Msc Abdul Jabbar
Khalid Msc Abdul Jabbar
JTJia Ying Bsc Tang
Jia Ying Bsc Tang
JGJonathan Gao
Jonathan Gao
YNYee Sien Ng
Yee Sien Ng
This review examined and compared the effects of exercise interventions using portable exercise equipment on muscle strength, balance, and ability to perform activities of daily living in the oldest-old and frail. We also examined the differences in the intervention characteristics between these two groups. The CINAHL, MEDLINE, and Cochrane databases were searched using specific text words and MeSH for randomized controlled trials published from 2000 to 2021, which involved exercise interventions for either oldest-old (≥75 yrs) or physically frail (reduced muscular strength, endurance, and physiological function) older adults. A total of 76 articles were included in this review, in which 61 studies involved oldest-old adults and 15 studies examined frail adults. Subgroup reviews of community dwelling and institutionalized adults were performed. The empirical evidence suggests that single-component and multicomponent exercise interventions produced positive effects for both older adult groups on muscle strength and balance, respectively. The effects of multicomponent interventions on muscular strength could be dependent on the number of exercise components per session. The effects of exercises on activities of daily living enhancement were less clear. We advocate for single intervention resistance training in all oldest-old and frail seniors to improve strength, if compliance to exercise duration is an issue.

6 February 2024 in JMIR Formative Research
Verified
Journal Article
Open access
CYChou Chuen Yu
Chou Chuen Yu
NTNien Xiang Tou
Nien Xiang Tou
JLJames Yiew Hock Low
James Yiew Hock Low
Background: Majority of individuals, including both younger and older adults, had to adapt to digital means to cope with lockdown measures and pandemic-induced lifestyle changes during the COVID-19 pandemic. While internet accessibility was beneficial during the pandemic, existing literature suggests that excessive use could lead to the rise of problematic internet use in adolescents and younger adults. However, the effects on older adults remain unclear. Objective: This study aimed to examine differences in internet use during the lockdown phase of the COVID-19 pandemic and explore how age differences in mental health could be explained by time spent on the internet. Methods: A door-to-door survey of a nationally representative sample of 602 adults in Singapore was carried out using computer-assisted personal interviewing during the early phase of the COVID-19 pandemic (October to November 2020). Participants were categorized into younger (21-59 years old) and older (60 years or above) age groups. We assessed self-reported measures of depression, anxiety, and stress; psychosocial adaptability; ability to perform essential activities; social support; health status; digital media use patterns, and time spent on the internet. Procedures complied with existing safe distancing measures. Results: Older adults reported being less able to use digital platforms to meet needs and acquire information updates compared with younger adults during the lockdown period of the pandemic. Older adults spent significantly less time on the internet for both work and personal uses per day (mean 146.00 min, SD 9.18 min) compared with younger adults (mean 433.27 min, SD 14.32 min). Significant age differences in depression, anxiety, and stress were found, with younger adults showing poorer mental health. Mediation analysis showed that age differences in depression, anxiety, and stress were partially explained by time spent on the internet. These variables together explained 43%, 40%, and 40% of the variances in depression, anxiety, and stress scores, respectively. Conclusions: The findings showed that younger adults spent significantly more time on the internet compared with older adults during the lockdown phase of the pandemic. They were also ahead in their ability to use digital resources to meet needs and engage socially compared with older adults. Despite this, the mental health of younger adults was poor, and this was partially accounted for by the amount of time spent on the internet. Since past research suggests that excessive time spent on the internet could lead to disordered use, the benefits brought by digital technologies could have been attenuated during the lockdown phase of the pandemic. Considering this potential negative effect, it is imperative to educate both young and old adults in the appropriate use of information and communication technology.

31 August 2022 in Aging and Health Research
Verified
Journal Article
Open access
NTNien Xiang Tou
Nien Xiang Tou
Shiou Liang WeeShiou Liang Wee
Shiou Liang Wee
BPBenedict Pang
Benedict Pang
LLLay Khoon Lau
Lay Khoon Lau
KJKhalid Abdul Jabbar
Khalid Abdul Jabbar
TNTze Pin Ng
Tze Pin Ng