The impact of boron (B) on the microstructure evolution and stabilization of mechanical properties in the IN718 superalloy during aging at 680 °C for 3000 h is investigated. The results indicated that B had negligible effects on grain size and the intragranular γ″ phase growth. In contrast, it effectively suppressed the precipitation and growth of the δ phase during long-term aging, which is attributed to grain boundary segregation of B that retards the diffusion of alloying elements. Adding B could improve the impact toughness and stability of the creep properties of the alloy. The primary mechanism is that the addition of B enhances grain boundary cohesion and suppresses the coarsening of the δ phase, while the beneficial effect of B on mechanical stability becomes negligible during the later stages of aging, as the severe coarsening of grain boundary phases offsets the enhanced grain boundary cohesion resulting from B segregation. Furthermore, the presence of slip bands was observed in the creep deformation mechanism of B-added alloys, which is likely attributable to B promoting dislocation slip at grain boundaries. With prolonged aging time, the dominant creep deformation mechanism in the B-modified alloy shifts from being primarily governed by twinning and dislocation slip to a mechanism involving twinning, stacking fault shearing γ″ phase, and dislocation slip.