Carbon fiber-reinforced polymer (CFRP) laminates are widely used in aircraft skins due to their advantages of high strength and lightweight properties. However, their laminate structure and energy-absorbing characteristics result in low-energy impact damage, such as delamination, that is often invisible but can lead to catastrophic failure. Consequently, early detection of delamination in CFRP laminates is necessary. Nonlinear ultrasonic guided waves exhibit high sensitivity to delamination, and second harmonics are widely employed. Compared to second harmonics, one-way mixing of ultrasonic guided waves can excite and receive signals simultaneously at the same location, thereby precisely localizing delamination. This capability has the potential for inspecting buried structures. However, existing literature has not yet fully addressed the generation mechanism of one-way mixing in CFRP laminates nor its interaction with delamination. Based on finite element simulation, this study investigates one-way mixing of A₀ modes and S₀ modes in CFRP laminates. Utilizing pulse-inversion techniques and two-dimensional fast Fourier transforms, the modes and propagation directions of difference-frequency components and sum-frequency components are determined. Furthermore, by utilizing the normalized acoustic nonlinearity parameter χ’ and adjusting the position of the mixing zone through different time delays, delamination in the CFRP laminate is successfully localized.