To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-MSM. Periodontitis was induced by placing 4.0 silk sutures in the subparamarginal position on the necks of the mandibular first molars and applying the suture for 5 weeks. The Ep-MSM group was given 500 mg/body weight/day MSM intraperitoneally for 35 days. At the end of the study, bilateral mandibular samples were taken. Periodontal bone loss was measured through histologic sections. Histomorphometric and immunohistochemical (receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG)) evaluations were performed on right mandibular tissue samples, and biochemical (interleukin (IL)-1 beta (β)/IL-10, malondialdehyde (MDA), glutathione (GSH), oxidative stress index (OSI)) evaluations were performed on left mandibular tissue samples. No significant difference was found between the groups in IL-1β and IL-1β/IL-10 values ​​(p > 0.05). A significant decrease in IL-10 levels was observed in the Ep-MSM and Ep groups compared with the control group (p < 0.05). MDA levels significantly increased in the Ep and Ep-MSM groups compared with the control group, and GSH levels significantly decreased in the Ep group compared with the other groups (p < 0.05). OSI values ​​were significantly higher only in the Ep group (p < 0.05). RANKL levels showed a significant increase in the Ep group compared with the other groups. OPG levels were significantly increased only in the Ep-MSM group (p < 0.05). The results of this study may suggest that MSM has preventive effects on alveolar bone loss and oxidative stress.

There is an increasing occurrence of periodontitis and metabolic syndrome (MetS), which is resulting in a decline in the overall quality of life. Both disorders can occur together since they are both linked to insulin resistance and systemic inflammation. However, evidence for a role of interleukin (IL)-20 in this comorbidity is very limited. This cross-sectional study aimed to comprehensively investigate, for the first time, the levels of RANKL/OPG, MMP-8 and OSI as well as the role of IL-20 in patients with MetS and periodontitis. The study included a total of 80 individuals, divided into four groups: 20 individuals who were healthy both systemically and periodontally, 20 individuals who were systemically healthy but had periodontitis, 20 individuals who had MetS but were periodontally healthy, and 20 individuals who had both MetS and periodontitis. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment loss, probing pocket depth) were evaluated. Gingival crevicular fluid (GGF) and serum samples were collected and used for biochemical assays. Enzyme-linked immunosorbent assay was used to determine the levels of IL-20, receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8) and oxidative stress index (OSI). IL-20 levels measured in serum and GCF were statistically significantly highest in patients with MetS and periodontitis (p = 0.001). Significant positive correlation was observed between serum and GCF IL-20 values and periodontal parameters (p < 0.05). There was a positive correlation between RANKL and RANKL/OPG levels and IL-20 and clinical parameters (p < 0.05). OSI values were found to be increased in the presence of both periodontitis and MetS (p = 0.001) and were positively correlated with serum and GCF IL-20 (p < 0.05). These data from the study suggest a correlation between IL-20 and both MetS and periodontitis. IL-20 may potentially worsen the condition of periodontal tissue by increasing both the oxidative stress levels, periodontal collagen degredation and the ratio of RANKL to OPG. This study was registered on ClinicTrials.gov (NCT06092853), 2023-10-10, retrospectively registered.

To compare the average values of fractal and radiomorphometric analysis measurements in patients using overdenture prostheses supported by two or three imp

TNF-α inhibitors (anti-TNF-α) decrease the amount of inflammatory cells, osteoclast formation, and bone loss. The purpose of this study was to in

Sağlık Bilimleri Alanında Uluslararası Araştırmalar-V kitabında birbirinden değerli bilimsel çalışmalar, belirli kriterlere göre yazılmış ve toplamda 14 bölüme yer verilmiştir. Sağlık alanında çalışan bilim insanlarının ana hedefi hastalıkları incelemek ve onları iyileştirecek en iyi tedavi şeklini araştırmaktır. İşte tam da bu noktada Sağlık Bilimleri Alanında Uluslararası Araştırmalar-V kitabımız, farklı sağlık alanında çalışan (Doktor, Diş Hekimi, Hemşire, Biyokimya uzmanları, v.b.) birçok bilim insanın araştırmalarını kapsayan çok önemli bilgiler içermektedir. Bu kitabın oluşturulmasındaki amaç, sağlığın farklı bilim dallarında çalışan bilim insanlarının deneyimleri ve araştırmaları ile ortaya çıkardıkları yeni yaklaşımları bir kitap altında toplamak ve okuyuculara sunmaktı. Bu bağlamda bir çok sağlık alanında görev yapan bilim insanlarının iş birliği içinde yapmış oldukları bu kitap, okuyucu kitlesi için oldukça zengin ve önemli başlıklar içermektedir. Bu kitap evrensel etik ilkeler doğrultusunda, bilimdeki yenilikler göz önüne alınarak oluşturulmuş bir kitaptır. Kitabın sağlık alanında bilimsel çalışma yapan tüm bilim okuyuculara önemli bir kaynak olması en büyük arzumuzdur. Kitabın zaman ve imkanlar ölçüsünde dikkatli şekilde hazırlanması amaçlanmıştır. Bu baskıda emeği geçen yayın evine ve bölüm yazarlarına teşekkürü bir borç bilir, çalışmalarında başarılar dileriz. In the book International Research in the Field of Health Sciences-V, valuable scientific studies were written according to certain criteria and included 14 chapters in total. The main goal of scientists working in the field of health is to examine diseases and research the best treatment to cure them. At this point, our book International Research in the Field of Health Sciences-V contains very important information covering the research of many scientists working in different health fields (Doctors, Dentists, Nurses, Biochemistry experts, etc.). The purpose of creating this book was to collect the experiences and research of scientists working in different branches of health and the new approaches they revealed under one book and present them to the readers. In this context, this book, which was prepared in collaboration with scientists working in many health fields, contains very rich and important topics for the readership. This book was created in line with universal ethical principles, taking into account innovations in science. Our greatest wish is for the book to be an important resource for all scientific readers doing scientific research in the field of health. It is aimed to prepare the book carefully within the time and possibilities. We would like to thank the publishing house and the chapter authors who contributed to this edition and wish them success in their work.