Background/Objectives: Corneal endothelial damage remains a key concern following phacoemulsification. This study aimed to quantify early postoperative changes in endothelial cell density metrics after cataract surgery in a Romanian population and to identify preoperative and intraoperative predictors of endothelial cell loss at 1 week and 1 month postoperatively. Methods: We conducted a retrospective observational study of 137 eyes that underwent standard phacoemulsification with intraocular lens implantation at Ocularcare Ophthalmology Hospital in Bucharest, Romania. Preoperative data included age, sex, and biometric parameters: anterior chamber depth (ACD), axial length (AL), and central corneal thickness (CCT). Corneal endothelium was assessed by specular microscopy preoperatively and at 1 week and 1 month postoperatively, with measurements of endothelial cell density (CD), number of analyzed cells (No), average cell size (ACS), minimum and maximum cell size (MinCS, MaxCS), and cell size variability (SD). Intraoperative parameters included average ultrasound energy (AVE) and actual phacoemulsification time (APT). Associations between demographic, biometric, and surgical variables and postoperative endothelial changes were analyzed using univariable and multivariable regression models. Results: In 137 eyes, mean CD decreased from 2401.99 ± 342.57 cells/mm² preoperatively to 2144.38 ± 449.92 at 1 week and 2053.15 ± 471.13 at 1 month. CCT increased from 534.64 ± 38.01 µm to 548.70 ± 41.34 µm at 1 week and remained higher than baseline at 1 month (545.67 ± 42.91 µm). Endothelial remodeling was reflected by significant increases in ACS, MaxCS, and SD, while No and MinCS showed no significant change. In adjusted models, lower postoperative CD was independently associated with shallower ACD and lower baseline CD at both timepoints, whereas higher AVE was associated with lower postoperative CD at 1 week but not at 1 month; sex was not independently associated with postoperative CD. Conclusions: In this Romanian cohort, phacoemulsification was associated with significant early endothelial cell loss measurable within the first postoperative month. The magnitude of CD reduction was influenced by both baseline patient ocular characteristics (ACD) and intraoperative phacoemulsification parameters, particularly ultrasound energy (AVE). These findings support the incorporation of preoperative biometric assessment and intraoperative ultrasound minimization strategies to reduce endothelial risk.

Background and Objectives: Secretory carcinoma of the breast is an uncommon histological subtype of breast cancer. There is little research on this entity and only a few larger studies, which lack consensus. We aim to report a particular apocrine differentiation in this subtype and ponder upon the clinical outcome of this case. Case presentation: We report the case of a 72-year-old female patient who presented to our hospital with a suspicious breast tumor. Core biopsy and mastectomy showed a low-grade breast carcinoma, a secretory subtype with apocrine differentiation. Immunohistochemistry confirmed both the secretory nature and the apocrine nature of the tumor cells. Surgical excision was considered curative and the patient is under long-term surveillance for any recurrences. Conclusions: There is very little research on the clinical behavior of secretory carcinomas with apocrine differentiation. The clinical outcome is unknown and, unfortunately, besides surgery, no other adjuvant treatments have shown efficacy. Further studies on long-term clinical progression are required for this rare entity.

Background and Clinical Significance: Mesonephric-like adenocarcinoma (MLA) of the ovary is a very rare entity that has only recently been recognized as a distinct subtype in the World Health Organization (WHO) classification. It is an aggressive tumor with a propensity for recurrence. The aim of this case report was to highlight the diagnostic challenges associated with MLA and the importance of immunohistochemical and molecular testing. Case Presentation: We report the case of a 59-year-old woman who presented with a left ovarian tumor. Histopathological examination led to an initial diagnosis of low-grade serous carcinoma, and the patient was treated accordingly. Five years later, the tumor recurred in the bladder wall and was initially interpreted as urothelial carcinoma. One year later, a further recurrence was identified at the vaginal cuff. Integrated review of the original ovarian tumor and recurrent lesions, together with immunohistochemical and molecular findings, supported the diagnosis of ovarian MLA with bladder and vaginal recurrences. Conclusions: Ovarian MLA is extremely rare and can mimic more common ovarian carcinoma subtypes. Awareness of its morphological and immunohistochemical features is essential to avoid misdiagnosis. MLA should be considered in recurrent gynecologic tumors with mesonephric morphology/immunophenotype even when the recurrence occurs in an unusual site such as the bladder and mimics a primary urinary malignancy.