Autonomous cleaning robots operating in semi-structured dynamic environments must execute task-oriented motions while safely interacting with surrounding agents. These agents include pedestrians, vehicles, and other robots. In such environments (e.g., interaction-rich campus environments), reliable self-decision-making requires anticipating the future motions of surrounding agents rather than relying solely on reactive obstacle avoidance. This paper presents a trajectory prediction-enabled self-decision-making framework for autonomous cleaning robots in campus environments. A learning-based multi-agent trajectory prediction model is trained offline using public benchmarks and real-world operational data to capture typical interaction patterns in corridor-following, edge-cleaning, and intersection scenarios. The predicted trajectories are then incorporated as forward-looking priors into the robot’s online decision-making and planning process, enabling prediction-aware yielding, detouring, and task continuation decisions. The proposed framework is evaluated using real-world data-driven scenario reconstruction on a high-fidelity simulation platform that incorporates realistic vehicle dynamics and heterogeneous traffic participants. This evaluation focuses on short-horizon prediction performance and its impact on downstream decision-making stability. The results show that integrating trajectory prediction into the decision-making loop leads to more stable motion behavior and fewer abrupt adjustments in interaction scenarios. Under short-term prediction horizons, the evaluation results show that the proposed model achieves ADERate and FDERate exceeding 90% under predefined error thresholds, while lane-change prediction accuracy remains around 79%. In addition, the robot maintains stable speed tracking with only minor fluctuations under medium-density traffic conditions.