Objective: To elucidate the impact of neck pain on cervical alignment in patients with TMDs. Method: Patients diagnosed with TMDs between November 2013 and November 2015 were included. All subjects underwent lateral cervical X-ray evaluation and completed the RDC/TMD Axis II Biobehavioral Questionnaire for TMDs. Patients with neck pain also completed the Neck Pain & Disability Scale (NPDS). Cervical lordosis angle was measured according to C2-C7 Cobb’s method. Results: The mean cervical lordosis angle of the whole group (n = 60) revealed hypolordosis (10.9 ± 12.7°). Cervical lordosis angle did not differ between patients with (n = 28) and without (n = 32) neck pain (12.2 ± 12.8° versus 9.8 ± 12.7°, respectively; p = 0.46). TMD-related variables were not correlated with cervical alignment but were moderately correlated with NPDS score, with the exception of TMD-associated disability. Conclusion: Patients with TMDs have hypolordotic cervical malalignment (tendency toward kyphosis) regardless of neck pain.

Purpose: Osteotoxicity, a common consequence of Methotrexate (MTX) therapy, significantly compromises bone health by inducing oxidative stress and disrupting bone remodeling. This study examines the protective effects of Tempol, a nitroxide compound with antioxidant properties, against MTX-induced osteotoxicity. Methods: Osteocyte-like MLO-Y4 cells were cultured and treated with Tempol and MTX to evaluate changes in apoptotic mediators, MAPK signaling pathways, and oxidative stress parameters. Results: MTX treatment significantly increased caspase-3 activity and Bax expression while decreasing Bcl-2 levels, thereby creating a pro-apoptotic environment. It also activated stress-related pathways by elevating JNK and ERK activities. Conversely, Tempol effectively countered these effects by restoring the balance of apoptotic mediators, downregulating MAPK activation, and enhancing Total Antioxidant Status (TAS). Additionally, Tempol reduced Total Oxidant Status (TOS) and improved the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Conclusion: These findings highlight Tempol’s potential to mitigate oxidative stress and apoptosis linked to MTX therapy, supporting its use as an adjunctive treatment to protect bone health in patients undergoing MTX therapy. Emphasizing Tempol’s clinical implications as a protective agent reinforces the urgency for further research into its long-term effects on cellular viability and bone integrity in the context of chemotherapy.

En tr Purpose: The aim of this study was to evaluate the correlation between early loss of first permanent molar (FPM) and temporomandibular joint disorder (TMD) symptoms in the children. Materials and Methods: 99 children (aged between 8 and 16) who had their FPM/s extracted at least two years ago were included in this study. The patients had clinical examination of oral status and temporomandibular joint (TMJ). Magnetic resonance imaging (MRI) findings were also evaluated with TMD symptoms. The correlation between the number of FPM loss and TMD symptoms was statistically analyzed. Results: Only one FPM loss was recorded in 59 children, while 34 had two FPM loss and 7 had three or four FPM extracted. 10 of these children (10.1%) had at least one TMD symptoms. A positive correlation was found between the number of FPM loss and at least one TMD symptom. Conclusion: The results of this study have shown the early loss of FPM has significant impact on TMD. The occlusion variations associated with eruption sequence and early FPM loss should be carefully followed to prevent TMD. Amaç: Bu çalışmanın amacı, çocuklarda daimi birinci azı dişin (FPM) erken kaybı ile temporomandibular eklem hastalıkları (TMD) semptomları arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: En az iki yıl ve daha öncesinde FPM çekilmiş 99 çocuk (8 ile 16 yaş arası) çalışmaya dahil edildi. Hastaların oral muayenesi ve temporomandibular eklem (TMJ) klinik muayenesi yapıldı. TMD semptomları ile Manyetik rezonans görüntüleme (MRG) bulguları da değerlendirildi. Kayıp FPM sayısı ve TMD semptomları arasındaki korelesyon istatistiksel olarak analiz edildi. Bulgular: 59 çocukta sadece bir FPM çekimi, 34'ünde iki FPM çekimi ve 7'sinde üç veya dört FPM çekimi yapıldığı kayıt edildi. Bu çocukların 10'unda (% 10.1) en az bir TMD semptomu görüldü. FPM çekim sayısı ile en az bir TMD semptomu arasında pozitif korelasyon bulundu Sonuç: Bu çalışmanın sonuçları erken FPM kaybının TMD üzerinde önemli bir etkisi olduğunu göstermiştir. Erüpsiyon sekansı ile ilişkili oklüzyon varyasyonlar ve erken FPM kaybı TMD'yi önlemek için dikkatle takip edilmelidir.

Amaç: Ağız kanserleri, ağızdaki yapıları veya dokuları etkileyen malign bir neoplazmdır. Oral skuamoz hücreli karsinoma deri, dudaklar ve oral kavitede mukoz membranda en sık görülen neoplazmdır. Haplophyllum buxbaumii, çok yıllık otsu bir bitkidir ve antioksidan özellikleri olduğu bildirilmiştir. Çalışmanın amacı Haplophyllum’un oral skuamoz kanser hücreleri üzerindeki antikanser etkilerini değerlendirmektir.Gereç ve Yöntem: Haplophyllum buxbaumii bitkisinden elde edilen ekstrenin skuamöz hücreli karsinom hücreleri üzerine etkileri, hücre canlılık testleri, total protein sayımı ve Elisa yöntemiyle caspase-3, Baxve Bcl-2 aktivitesi ile incelenmiştir. Bulgular: Çalışmanın sonuçlarına göre Haplophyllum ekstresi uygulaması, kontrollerle karşılaştırıldığında skuamöz hücreli karsinom hücrelerinin canlılığını azaltırken apoptotic yolağı da aktive etmiştir.Sonuç: Haplophyllumbuxbaumii bitki ekstresini skuamöz hücreli karsinom hücreleri üzerinde toksik etki göstermiş olup bu kanserin terapisine yönelik çalışmalara katkı sağlayacaktır. Çalışmamız bu bitkinin antikanser potansiyeli olduğunu göstermektedir.

Purpose: The aims of this study were to compare the mechanical properties of piezo-surgical tips such as nano-hardness, elastic modulus, surface roughness, and wear level, and to measure their cutting performance. Materials and Methods: In this study, 31 piezo-surgical tips were used, three for control and 28 for testing. The testing tips were equally divided into four groups with different numbers of osteotomies: the four-, 8-, 16-, and 32-osteotomy groups. The mean osteotomy duration was recorded during osteotomy. Scanning electron microscopy images of the tips in the test groups were obtained before and after osteotomy, and the wear level of the tips was measured. Results: A statistically significant increase was observed in the nano-hardness of the piezo-surgical tips depending on the number of osteotomy (for 4-use; 22.47±1.67H and for 32-use; 28.49±3.42H). The elasticity value of the testing tips was in the range of 218.55±15.74E to 241.26±10.46E, and all of the values were significantly higher than those in the control group (174.39±13.53E). As the frequency of use increased, a significant increase in surface roughness was observed (from 16.67±1.50 to 56.12±2.60). A positive correlation was found between the frequency of use and the wear level of the tips, and between the surface roughness and wear level of the tips. Conclusion: With the increase in the number of osteotomies, significant changes in the mechanical and physical properties of the piezo-surgical tips that affected their bone-cutting performance were observed.