Background: Cardiac arrest and cardiomyopathy are major contributors to cardiovascular mortality and sudden death. However, long-term national mortality trends and demographic disparities remain unclear. This study aimed to evaluate U.S. mortality trends from 1999 to 2025 and assess differences by sex, race/ethnicity, and age. Methods: We conducted a cross-sectional analysis of U.S. mortality data from 1999–2025 using the CDC WONDER Multiple Cause-of-Death database. Deaths among adults aged ≥25 years were identified using ICD-10 codes I42 (cardiomyopathy) and I46 (cardiac arrest), including cases where these codes appeared as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated. Temporal trends were assessed using Joinpoint regression and expressed as average annual percent change (AAPC), stratified by sex, race/ethnicity, and three age groups (25–44, 45–64, and ≥65 years). Results: Between 1999 and 2025, 237,958 deaths from cardiac arrest and cardiomyopathy occurred among U.S. adults ≥25 years. Overall, AAMR declined from 6.33 to 2.41 (AAPC −3.83; 95% CI: −4.18 to −3.57). Males had higher mortality than females (AAMR 5.82 vs 2.71) with declines from 9.13 to 3.28 and 4.36 to 1.62, respectively. Non-Hispanic (NH) Black individuals had the highest AAMR (7.42), followed by Hispanics (4.62). Mortality was highest among those aged ≥65 years (CMR 14.74), declining from 23.88 to 7.88 between 1999 and 2025. Conclusion: Mortality from cardiac arrest and cardiomyopathy declined significantly from 1999–2025. However, substantial disparities persisted, with higher mortality among males, NH Black individuals, and adults ≥65 years, highlighting ongoing inequities in cardiovascular outcomes.

Background: Cardiogenic shock (CS) complicated by sepsis is a life-threatening condition marked by circulatory collapse and systemic inflammation, with persistently high mortality despite critical care advances. National trends and disparities remain unclear. This study aimed to evaluate temporal mortality trends from 1999 to 2025 and project rates through 2040. Methods: We conducted a population-based study using U.S. mortality data (1999–2025) from the CDC WONDER database. Deaths among adults aged ≥25 years with CS and sepsis were identified using ICD-10 codes. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Joinpoint regression estimated annual percent change (APC) and average annual percent change (AAPC). Forecasting models projected mortality trends through 2040. Results: From 1999 to 2025, 71,726 deaths occurred; 97.09% in medical facilities. Overall, AAMR rose from 0.65 to 2.16 (AAPC 5.01%, p < 0.001) and is projected to reach 3.62 by 2040. Men had higher mortality than women (2025: 2.78 vs 1.65; AAPC 5.06% vs 4.91%). In 2025, AAMR was 3.75 among NH Black individuals, 1.98 among NH White individuals, and 2.01 among Hispanic individuals. Adults ≥65 years had the highest CMR (7.50 in 2025; AAPC 4.63%), with the largest relative increase in ages 25–44 (AAPC 7.19%). Conclusion: CS with sepsis mortality increased significantly from 1999 to 2025, particularly among men, NH Black individuals, and adults ≥65 years. Although recent trends have stabilized, projections indicate continued increases through 2040, highlighting persistent and widening demographic disparities in the mortality burden.

Background: Tobacco use is a major risk factor for ischemic heart disease (IHD), substantially increasing the likelihood of myocardial infarction, stroke, and premature mortality. This study examined U.S. trends in IHD mortality with documented tobacco use disorder from 1999 to 2023. Methods: CDC mortality data for adults aged ≥ 25 years with IHD (ICD-10 codes: I20–I25) and documented tobacco use (ICD-10 code: F17) listed as contributing causes of death were analyzed. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated. Joinpoint regression was used to estimate annual percent change (APC) and average annual percent change (AAPC). Results: From 1999 to 2023, 1,497,919 deaths were reported. The AAMR rose from 3.90 to 32.37 (AAPC: 10.71; p < 0.01). Males had a higher AAMR (39.68; AAPC: 10.72) than females (14.05; AAPC: 10.77). Non-Hispanic (NH) Whites had the highest AAMR (26.86), followed by American Indians (25.43), NH Blacks (19.77), and Hispanics (10.38). The Midwest had the highest regional AAMR (32.96). Most deaths occurred in inpatient facilities (27.9%). Adults aged ≥ 65 years had the highest mortality rate (CMR: 92.16). Rural areas exceeded urban (35.73 vs. 22.95). Conclusion: IHD mortality with documented tobacco use has risen sharply, disproportionately affecting older adults, males, rural areas, the Midwest, and NH Whites.

From the 8th International Cancer Congress

From the 8th International Cancer Congress