The Arco Verde Complex, exposed in the Serra do Inajá region of the Rio Maria Domain (Carajás Province, Amazonian Craton), represents one of the oldest TTG granitoid association of the province (3.00–2.92 Ga). While TTG magmatism is well constrained in the northern domain, its southern sector lacks precise geochronological data. This study integrates petrographic, geochemical, U–Pb zircon geochronology, and Nd–Hf isotopes to constrain the age, source, and crustal significance of these granitoids. Uranium–Pb zircon dating of two granodiorites yielded ages of 2979 ± 8 and 2979 ± 11 Ma, extending the 2.98 Ga TTG magmatic episode to the southern sector of the Rio Maria Domain. Geochemical data indicate dominant tonalites formed by partial melting of a similar mafic source at different crustal depths, whereas subordinate granodioritic and monzogranitic rocks show transitional TTG affinities. These features indicate coeval mafic and felsic crust rapidly reworked after formation. Hf and Nd model ages of 3.0–3.2 Ga, with positive ε_Hf–Nd at 2.98 Ga, reinforce the Early Mesoarchean as the main crustal growth period in the province. In addition, we propose that the differentiation of the depleted mantle (DM) beneath the Carajás Province may have initiated around 3.8 Ga.