Cansjera rheedei J.F.Gmel. belongs to the family Opiliaceae, which is distributed in the regions of southern Asia. Research on this plant’s chemical constituents has been limited to the identification of several common phenolic compounds. This phytochemical study was conducted on the stems of C. rheedei to isolate five lignans and one neolignan. The chemical structures of six isolated compounds were elucidated by using spectral data analyses and comparison with those in references, leading to the determination of alyterinate A (1), alyterinate B (2), (+)-pinoresinol (3), (+)-medioresinol (4), (+)-syringaresinol (5), and balanophonin (6). All of them were reported for the first time from the genus Cansjera.

Recent phytochemical investigations have demonstrated that Luvunga scandens is a rich source of structurally diverse secondary metabolites; however, its potential antioxidant-active constituents and their underlying mechanisms remain largely unexplored. In this study, an NMR-guided fractionation strategy applied to the rhizomes and leaves of L. scandens led to the isolation of ten limonoids, including three new compounds, Luvungas B–D (3, 4, and 8). Their structures and absolute configurations were determined through extensive spectroscopic analysis, X-ray diffraction, and ECD calculations. Based on the isolated analogues, a biosynthetic pathway is proposed, featuring the metabolic bifurcation of a key acyclic intermediate into the isoobacunoic acid and propellane-type lineages. Biological evaluation revealed that 8 inhibits RSL3-induced ferroptosis in HepaRG liver cells with an EC₅₀ of 16.1 µM. Mechanistic studies demonstrated that, unlike classical antioxidants, compound 8 mitigates lipid peroxidation without exhibiting direct radical-scavenging or iron-chelating activities. These findings suggest that 8 suppresses ferroptosis via non-canonical mechanisms.