Poor performance in the 6-min walk test (6MWT < 350 m) is an important prognostic indicator of mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Little is known about the stability of this state over time and what factors might predict a poor 6MWT performance. To determine the stability of 6MWT performance over a 2-year period in COPD patients participating in annual medical follow-up visits, and to assess the ability of several clinical, pulmonary, and non-pulmonary factors to predict poor 6MWT performance, we prospectively included 137 patients with stable COPD (mean age, 66.9 ± 8.3 years). The 6MWT was scored at baseline and 2-year follow-up. To evaluate clinical, pulmonary, and non-pulmonary variables as potential predictors of poor 6MWT performance, we used multiple logistic regression models adjusted for age, sex, weight, height, and 6MWT performance at baseline. Poor 6MWT performance was stable over 2 years for 67.4% of patients. Predictors of poor 6MWT performance included a five-repetition sit-to-stand test score ≤2 (OR, 3.01; 95% CI, 1.22–7.42), the percentage of mobility activities with limitations (OR, 1.03; 95% CI, 1.00–1.07), and poor 6MWT performance at baseline (OR, 4.64; 95% CI, 1.88–11.43). Poor 6MWT performance status was stable for the majority of COPD patients. Lower scores on the five-repetition sit-to-stand test and a higher number of mobility activities with limitations were relevant predictors of poor 6MWT performance over 2 years. Prognostic models based on these non-pulmonary factors can provide non-inferior discriminative ability in comparison with prognostic models based on only pulmonary factors.

Background: Women with endometriosis frequently experience mobility limitations that affect daily functioning. A specific tool to assess these restrictions would help clinicians to better understand patients’ functional challenges, facilitating more effective communication and shared decision making. Addressing this gap is essential for strengthening patient–professional dialogue and improving individualized care. Objective: To develop the new instrument MobEndo and to perform initial psychometric testing of the tool. Methods: The initial domains and items were generated through semi-structured interviews with patients and based on experts’ advice. Guided by the International Classification of Functioning, Disability, and Health (ICF) framework, exploratory factor analysis was conducted on data from patients diagnosed with endometriosis. Internal consistency was assessed using Cronbach’s alpha, considering values ≥ 0.70 as acceptable. Test–retest reliability was examined using intraclass correlation coefficients (ICCs), and ICC values were judged as excellent if >0.75. Construct validity was evaluated through concurrent, discriminant, and known-groups validity. For the known-groups validity hypothesis, participants were categorized by baseline pain levels. Results: The final questionnaire included 18 items, developed from responses from 301 women (mean age 38.96 ± 6.85). Factor analysis revealed two components—transitioning between body positions and performing movements requiring stabilization and executing load-bearing tasks involving the upper limbs—with the model explaining 71.78% of the total variance. Reliability was excellent, with a Cronbach’s alpha of 0.977. The ICC for the total score was 0.976 (95% CI 0.949–0.988), with similarly high values for each component. Concurrent validity correlations were significant, while discriminant validity showed no relevant associations. Known-groups analyses showed clear differences across pain-level groups. Conclusions: The questionnaire is a valid and reliable tool for capturing women’s perceived mobility limitations in endometriosis.