High rate of platelet adhesion and limited biocompatibility were regarded as the chief weaknesses of vascular tissue engineering scaffolds. The objective of this research was to overcome these drawbacks by ultilizing coaxial electrospinning to combine CDPS with PLA. CDPS and PLA were located at the inner and external layer respectively so that a “core-sheath” structure was formed. The properties of scaffolds were tested by methods such as mechanical testing, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay and subcutaneous transplantation. Compared to natural tissues, CDPS/PLA coaxial scaffolds showed excellent biomechanic properties and hemocompatibility so that CDPS owned good potentiality in vascular tissue engineering. GRAPHICAL ABSTRACT

Porous composite scaffold with Ligusticum wallichii polysaccharide and squid skin collagen was synthesized and characterized. The composite scaffold showed good phosphate buffer solution (PBS) retention ability, slow biodegradation rate, high mechanical strength, and superb cell proliferation promoting ability. The PBS content value increased from 433.40% to 571.05%; the weight lost in seven days decreased from 95.41% to 34.35%; the tensile strength of sample increased from 0.19 to 0.81 MPa; the seven-day relative growth rate of cell in composite (polysaccharide:collagen = 5:5) is twice of that in pure collagen. While with the polysaccharide portion increased, the elongation at break decreased from 93.09% to 9.60%.