Visual fatigue is a serious issue among Chinese secondary school students owing to prolonged daily exposure (8–10 h) to visual display terminals (VDTs) in widely equipped multimedia classrooms. To mitigate such effects, this exploratory study identifies promising lighting parameters by evaluating the influence of blackboard reflection coefficients, the ratio of desktop illumination to blackboard illumination, and correlated color temperature (CCT) in a simulated multimedia classroom environment. Thirteen participants performed visual tasks (Landolt ring visual acuity tests and Anfimov’s Chart Task) under various conditions. Visual fatigue scale (VFS-10), index of mental capacity (IMC), and eye movement parameters (EMP) were used to assess visual fatigue and efficiency. Results suggest that higher blackboard reflection coefficients improved efficiency and reduced fatigue. Increased blackboard illumination alleviated fatigue at constant CCT, whereas changes in desktop illumination showed no significant effect. The highest efficiency among the tested CCT values was observed at 4700 K, while visual fatigue was minimized at 4000 K. The findings provide preliminary practical applications for minimizing visual fatigue and improving performance efficiency in secondary school multimedia classroom environments equipped with VDTs.