Serena Zanardo

Dr. Serena Zanardo

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Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 August 2026 in Thoracic Cancer
Verified
Journal Article
Open access
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ABAlessandro Bonis
Alessandro Bonis
GPGiulia Pagliarini
Giulia Pagliarini
VVVincenzo Verzeletti
Vincenzo Verzeletti
SCSara Cecchinato
Sara Cecchinato
AMAnna Michielin
Anna Michielin
ADAndrea Dell’Amore
Andrea Dell’Amore
Purpose: Ground‐glass opacities (GGOs) are increasingly detected due to widespread low‐dose CT screening for lung cancer. Among them, malignant GGOs (mGGOs) are a clinical challenge. This study aimed to compare the radiological and anatomopathological characteristics of pure and semi‐solid mGGOs and to identify radiological predictive factors for consolidation. Methods: A retrospective study was conducted on patients resected due to mGGOs between 2016 and 2023. Patients were classified based on whether initially pure mGGOs remained pure or developed a solid component before surgery. Radiological, pathological, and molecular characteristics were analyzed. Results: Of 135 patients, 61 (46%) mGGOs became partially solid during surveillance. Semi‐solid mGGOs had a higher acinar component ( p = 0.038) and larger pathological diameter (20 vs. 18 mm, p = 0.047), while pure mGGOs had a higher lepidic percentage (20% vs. 10%, p = 0.026). STAS and LVI were observed in 25% and 15% of cases. Logistic regression showed pleural contact was protective against consolidation ( p = 0.033), while arterial vascularization was predictive of consolidation ( p = 0.028). Five‐year survival was comparable and satisfactory for both groups (81.7% for pures and 85.5% for semi‐solids). Overall, LVI but no STAS was cause of a lower survival expectancy in the entire sample, regardless of consolidation ( p = 0.004). Conclusions: Both pure and semi‐solid mGGOs showed precocious pathological and molecular features. Surgical intervention with curative intent, even in pure GGOs, is accompanied by long expected survivals. Vascular features on imaging may help inform surgical decision‐making, whereas pathological LVI may have prognostic significance in patients with mGGOs.

27 March 2026 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
SZSerena Zanardo
Serena Zanardo
FLFrancesco Londero
Francesco Londero
YBYvonne Beorchia
Yvonne Beorchia
LCLuigi Castriotta
Luigi Castriotta
EFElisa De Franceschi
Elisa De Franceschi
AZAndrea Zuin
Andrea Zuin
Background/Objectives: Several studies previously investigated the risk factors for post-operative recurrence of primary spontaneous pneumothorax (PSP), with conflicting results. Identification of patients at greater risk of recurrence may help optimize therapeutic strategies. The aim of this study is to identify potential predictors of post-operative recurrence of PSP and compare our results with the available literature. Methods: We retrospectively evaluated all patients who underwent surgery for PSP at our institution between January 2005 and December 2022. We analyzed data on patient characteristics, surgical details, method of pleurodesis and perioperative outcomes and used Cox regression analysis to identify predictors post-operative ipsilateral recurrence. Results: 226 patients were included in our study, of which 29 (12.8%) developed an ipsilateral recurrence of pneumothorax. A positive history of previous contralateral episodes (37.9% vs. 19.3%, p = 0.03) and the positioning of larger chest drains after the procedure (65.5% vs. 44.8%, p = 0.032) were more frequent in the recurrence group. At multivariable regression analysis, a history of previous contralateral pneumothorax was found to be the only independent predictive factor of pneumothorax recurrence (HR 2.16, 95% C.I. 1.001–4.662, p = 0.049). Conclusions: Previous contralateral pneumothorax is a risk factor for the development of post-operative recurrences.