Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease in which accurate assessment of disease activity remains challenging. Although composite indices such as BASDAI and ASDAS are widely used, they may not fully capture systemic inflammatory burden. The C-reactive protein–albumin–lymphocyte (CALLY) index is an emerging composite biomarker integrating inflammatory, nutritional, and immunological components. This study aimed to evaluate the association of the CALLY index with disease activity, functional status, and quality of life in AS. Methods: This medical record-based cross-sectional study included 65 patients with AS. Disease activity was assessed using BASDAI and ASDAS-ESR, functional status using BASFI, and quality of life using the 12-Item Short Form Health Survey (SF-12). The CALLY index was calculated from serum CRP, albumin levels, and lymphocyte counts. Correlation and multivariable linear regression analyses were performed. Results: The mean CALLY index was 58.43 ± 66.20. The index showed moderate negative correlations with ESR and ASDAS-ESR and a positive correlation with lymphocyte count. Its strong inverse correlation with CRP was expected because CRP is part of the formula and was therefore interpreted cautiously. No significant associations were found with BASDAI, BASFI, or SF-12. In multivariable analysis, BMI (β = −0.299, p = 0.012) and NSAID use (β = −0.298, p = 0.011) were independent predictors. Conclusions: The CALLY index was associated mainly with objective inflammatory markers rather than patient-reported outcomes, suggesting a dissociation between biochemical and clinical disease domains in AS. These findings are preliminary and require confirmation in larger longitudinal studies before clinical application.

Introduction: Chronic inflammatory diseases (CIDs) are lifelong complex disorders that affect quality of life, and this study aimed to summarize 5 years of experience with a multidisciplinary approach for these complex diseases as a result of medical council meetings. Methods: Hospital-based, medical records review study was conducted. A total of 45 monthly medical council meetings were held between 2014-2019 with the participation of the rheumatology, dermatology and gastroenterology departments of the same university. Patients with complex conditions that were seen in each department's own polyclinic composed the council. This study only included 308 patients referred by the rheumatology group. Results: Females made up 66.5 % of the 308 patients. The median age was 45 (19-77). PsA (psoriatic arthritis) and other SPA (spondyloarthritis) patients composed 49.3% of the total. A total of 68.18% of the patients were presented only to consult with the dermatology department. The most common reason for presenting patients was to discuss options for treatment (41.5%). The diagnosis of psoriasis was confirmed in 48 of 67 (71.6%) patients who presented with a pre-diagnosis. The diagnosis was changed in 34.74% of the patients, whereas the diagnosis became completely different in 11.36% of the patients. Conclusions: Many patients with challenging diagnosis and treatment processes are encountered in daily practice. The combination of different disciplines makes it possible to provide more rapid and effective solutions. In this study, we aimed to emphasize the increasing importance of such multidisciplinary approaches

Objectives. Cervical radiculopathy is one of the common causes of the neck pain. Medical devices in the form of cervical collars are frequently recommended in acute cervical radiculopathy. We aim to investigate and compare the effect of soft and semi-rigid cervical collars on neck pain, disability and daily life activities in the patients with acute cervical radiculopathy. Methods. We designed a prospective, single-blind, randomized controlled study. This study was conducted on 101 patients who were diagnosed with clinical features of radiculopathy and imaging showing cervical disc herniation. Visual Analog Scale (VAS), Neck Disability Index (NDI) and SF-36 were applied to the subjects. Evaluation of the patients was done before the treatment and 2 weeks and 6 weeks after the start of the treatment. Patients were divided into three groups according to the computer-generated randomization table: Soft cervical collar, semi-rigid cervical collar and control group. The patients in collar groups were asked to wear the collars for 8 hours during the day for the first 2 weeks.Results. Comparison of the soft cervical collar group with the control group showed significantly better improvement in the former in VAS and NDI scores at week 2 and 6 (p < 0.05), in SF-36 pain perception subunit at week 2 (p < 0.05), and in SF-36 physical component score at week 6 (p < 0.05). Comparison of the semi-rigid cervical collar group with the control showed significantly better improvement in the former for NDI scores and SF-36 pain perception subunit at week 2 and 6 (p < 0.05). Conclusions. The results of our study have indicated that the use of soft and semi-rigid cervical collars was more effective than conservative treatment in treatment of neck pain and disability in acute cervical radiculopathy in the short term. Soft cervical collars were also found to be more effective for pain management than semi-rigid cervical collars.

Çalışma, Behçet hastalarının uyku kalitesi, depresyon düzeyleri ve etkileyen faktörleri belirlemek amacıyla tanımlayıcı olarak yapıldı. Çalışmaya katılmayı kabul eden 44 Behçet hastası çalışmaya dahil edildi. Çalışmanın verileri, araştırmacılar tarafından hazırlanan “Hasta Bilgi Formu”, “Pitsburg Uyku Kalitesi İndeksi (PUKİ)”, “Beck Depresyon Ölçeği (BDÖ)”, Behçet Hastalığı Yaşam Kalitesi Ölçeği (BHYKÖ)” ve “Behçet Hastalığı Güncel Aktivite Formu” ile toplandı. Verilerin değerlendirilmesinde, Mann Whitney U ve Spearman korelasyon analizleri yapıldı. Hastaların yaş ortalamasının 37,38±8,33 yıl, %90,9'unun erkek ve hastalık süresi ortalamasının 7,54±4,72 yıl olduğu belirlendi. Genital ülseri olan hastaların PUKİ puanının anlamlı olarak yüksek olduğu saptandı (p0,05). Hastalık aktivite skoru ile PUKİ, BDÖ, BHYKÖ puanları arasında anlamlı ilişki olduğu belirlendi (p

Background and Objectives: Familial Mediterranean fever (FMF) is a chronic autoinflammatory disease characterized by recurrent inflammatory attacks and a persistent psychosocial burden. Although generalized anxiety symptoms have been investigated in FMF, disease-specific anticipatory concerns related to recurrent attacks remain insufficiently understood. This study aimed to investigate the associations of attack-related anticipatory anxiety symptoms with clinical characteristics, quality of life, and composite inflammatory indices in FMF. Materials and Methods: This exploratory cross-sectional study included 38 adult patients with FMF. Attack-related anticipatory anxiety symptoms were assessed using an exploratory six-item questionnaire. Generalized anxiety and quality of life were evaluated using the Generalized Anxiety Disorder-7 (GAD-7) and Short-Form–12 (SF-12), respectively. Composite inflammatory indices including the C-reactive protein–albumin–lymphocyte (CALLY) index, log-CALLY, hemoglobin–albumin–lymphocyte–platelet (HALP) score, and systemic immune-inflammation index (SII) were calculated from routine laboratory parameters. Results: Attack-related anticipatory anxiety scores demonstrated a significant positive correlation with GAD-7 scores (r = 0.581, p < 0.001) and an inverse correlation with SF-12 mental component scores (r = −0.380, p = 0.019). Direct correlations between attack-related anticipatory anxiety scores and composite inflammatory indices were weak and not statistically significant. In subgroup analysis, a higher annual attack burden was associated with higher GAD-7 scores, higher CRP and serum amyloid A values, and lower CALLY, log-CALLY, and HALP values. Differences in attack-related anticipatory anxiety, SF-12 MCS, and SII between attack burden groups did not reach statistical significance. In multivariable linear regression analysis, GAD-7 score remained independently associated with attack-related anticipatory anxiety symptoms (β = 0.438, p = 0.010). Conclusions: Attack-related anticipatory anxiety symptoms may represent an exploratory psychosocial dimension of FMF associated mainly with generalized anxiety symptoms and impaired mental well-being. Composite inflammatory indices appeared more closely related to annual attack burden than to attack-related anticipatory anxiety. These findings should be interpreted cautiously and considered hypothesis-generating.