Background: The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O₂O₃) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear.Methods: Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O₂O₃gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week.Results: When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups.Conclusions: The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.

Background and objective Bone marrow edema (BME) is a rare condition caused by insufficient osseous blood supply and may result in severe pain that has adverse effects on patients' life. To date, various conservative treatments have been recommended for the treatment of BME, including analgesics, immobilization of the affected extremity, and iloprost infusion. The aim of this retrospective study was to investigate the effectiveness of parenteral iloprost therapy in the treatment of BME detected in different skeletal locations. Materials and methods This retrospective study included 23 patients (17 men and six women) with BME who were classified as stage I-III according to the Association Research Circulation Osseous (ARCO) classification. BME was localized to the proximal femur in 13 (56.5%), the distal femur in four (17.4%), tarsal bone in four (17.4%), and tibial plateau in two (8.7%) patients. The mean age of the patients was 46.7 years and all the patients were evaluated with the Visual Analog scale (VAS), Functional Mobility Scale (FMS), and MRI. Results A significant improvement was observed in the post-treatment VAS and FMS scores of all patients compared to their pre-treatment scores. Moreover, the edema regressed completely in 60.9% of the patients at three months of MRI control. No serious side effects were observed during the treatment in any of the patients. However, transient side effects including headache, arrhythmia, and flushing were observed in five patients. Conclusion The present study indicated that iloprost therapy is an effective and safe option in the treatment of BME patients, particularly in the reduction of severe pain that has adverse effects on patients' social life, regardless of ARCO staging. Moreover, this therapy could be particularly useful in reducing pain, improving functional recovery, and achieving complete regression of the edema on MRI in ARCO stage I-II patients.

We aimed to evaluate the clinical and radiological outcomes of children older than 18 months who were treated with Salter osteotomy without open reduction for Tönnis type II hip dysplasia. Thirty-two type II hips of 24 patients were included in the study. The mean age was 43.22 (18–108) months. The mean follow-up period was 50 (24–142) months. Seven patients had left sided, nine had right sided, and eight had bilateral developmental dysplasia of the hip. All patients underwent closed reduction and Salter osteotomy. Preoperative and postoperative radiographs were assessed by measuring the center-edge (CE) angle of Wiberg, Smith’s c/b and h/b ratio, and acetabular index (AI). Patients were evaluated clinically according to McKay’s criteria and radiologically according to Severin criteria. The Kalamchi and MacEwen criteria were used in the evaluation of avascular necrosis. The mean preoperative AI, CE angle, c/b, and h/b ratio were 36.7° (±4.1), 7.2° (±5.9), 0.9 (±0.08), and 0.05 (±0.04), respectively. The mean latest follow-up AI, CE angle, c/b, and h/b ratio were 18.2° (±1.7), 38.8° (±5.4), 0.6 (±0.03), and 0.19 (±0.04), respectively. The comparison of preoperative and postoperative radiological values revealed statistically significant improvement (p < 0.01). On the latest physical examinations of the patients, 25 (78.1%) hips were rated excellent, and 7 (21.9%) were rated good according to the McKay criteria. The Severin classification determined 25 (78.1%) hips were grade I and 7 (21.9%) hips were grade II. Type I avascular necrosis (AVN) was seen in four (12.5%) hips. Three of these four hips were more superolateral in preoperative radiographs (c/b > 1 and h/b < 0.05). Salter osteotomy without open reduction is a good surgery option for Tönnis type II hip dysplasia, in which closed reduction can be performed. However, the risk of AVN should be kept in mind in more superolateral type 2 hips.

Background and Design: Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus affecting the skin and peripheral nervous system. Leprosy can lead to severe deformities depending on the extent of the disease. In this study, we aimed to investigate the quality of life of patients with lepromatous leprosy. \ud Materials and Methods: Thirty-five patients with lepromatous leprosy and 35 healthy controls were included in the study. The patients were evaluated with the Turkish version of the Dermatology Life Quality Index (DLQI) and the 36-Item Short Form Health Survey (SF-36). The relationship of quality of life with age, gender, marital status, and the grade of the visual impairment was studied and compared with the healthy controls. \ud Results: Total and all the subgroup DLQI scores were higher in the leprosy group than in the control group (p<0.05). The patients with grade 2 visual impairment were more severely affected by the disease with regard to symptoms/feelings and school/work life as compared to the patients with grade 1 visual impairment (p=0.04, p=0.03, respectively). SF-36 physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, and emotional role functioning scores were statistically lower in the patient group than in the control group (p<0.05). \ud Conclusion: We observed that DLQI scores were lower in patients with lepromatous leprosy than in the control group, while increasing impairment in eyes was found to have a negative impact on quality of life. The SF-36 revealed that physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, emotional role functioning, and mental health were negatively influenced in patients with lepromatous leprosy

Osteogenesis Imperfecta (OI) is a connective tissue disease that is the most common genetic cause of osteoporosis and is characterized by deformities and fractures in long bones. This disease occurs due to the deficiency of Type 1 collagen. Orthopedically, it is aimed to treat and prevent deformities and fractures in the extremities. The aim of this study is to evaluate the results of patients who were hospitalized with the diagnosis of osteogenesis imperfecta in our clinic and who underwent telescopic nailing by comparing them with the literature. In this study, 15 patients diagnosed with Osteogenesis Imperfecta who were admitted to the Orthopedics and Traumatology Clinic of Fırat University Faculty of Medicine Hospital and treated surgically between 2015 and 2021 were retrospectively examined. A total of 43 lower extremity bones were treated with telescopic nails, and the patients were followed for an average of 4 years. The primary outcome was the rate of revision surgeries required due to complications such as refracture, pseudoarthrosis, or nail migration. Descriptive statistical analysis was performed using SPSS software (version 27.0). Total of 43 lower extremity bones were surgically treated with telescopic nails. The patients were followed for an average of 4 years. The mean revision time was 28 months for femur and 35 months for tibia. The revision rate was 16.6% for femoral surgery and 7.69% for tibial surgery. No cases of non-union or postoperative infection were observed. The overall complication rate was 13.9%. The average union time was 45 days. No postoperative infections were observed in any of the 43 operated extremities. Intraoperative bleeding was generally minimal and well-controlled; only 4 patients required perioperative transfusion of one unit of erythrocyte suspension. According to Hoffer and Bullock ambulation grading, 11 patients had unassisted ambulation, while only 2 remained wheelchair-dependent. These results suggest that the telescopic nail method, when applied with a minimally invasive approach, may be considered a reliable technique with a low complication rate and favorable functional outcomes in the management of OI-related lower extremity deformities.