Resistance May Not Be Futile: Recently, Ug99, a particularly devastating strain of wheat stem rust fungus, has emerged, which could potentially threaten food security. Now, two genes have been cloned that offer resistance to Ug99. Saintenac et al. (p. 783 , published online 27 June) cloned Sr35 from Triticum monococcum , a diploid wheat species not often cultivated. Periyannan et al. (p. 786 , published online 27 June) cloned Sr33 from Aegilops tauschii , a diploid wild grass that contributed to the hexaploid genome of cultivated wheat. The genes both encode proteins that show features typical of other disease resistance proteins and offer opportunities to slow the pace of Ug99 progression.