The world evolves continuously across space and time. Massive volumes of data are generated through sensing, simulation, remote observation, and human activities, capturing dynamic processes in environmental, social, economic, and engineered systems. Critical insights are embedded within these large-scale spatiotemporal datasets. Spatiotemporal Data Science provides a conceptual and methodological framework for analyzing such data by integrating spatiotemporal thinking, computational infrastructure, artificial intelligence, and domain knowledge. The field advances methods for data acquisition, harmonization, modeling, visualization, and decision support, enabling applications in natural disaster response, public health, climate adaptation, infrastructure resilience, and geopolitical analysis. By leveraging emerging technologies—including generative Artificial Intelligence (AI), large-scale cloud platforms, Graphics Processing Unit (GPU) acceleration, and digital twin systems—Spatiotemporal Data Science enables scalable, interoperable, and solution-oriented research and innovation. It represents a critical frontier for scientific discovery, engineering advancement, technological innovation, education, and societal benefit. Spatiotemporal Data Science is a transdisciplinary field that studies and models dynamic phenomena across space and time by integrating spatial theory, temporal reasoning, artificial intelligence, and scalable computational infrastructure. It enables the development of adaptive, predictive, and increasingly autonomous systems for understanding and managing complex real-world processes.