Josefina Aleu

Dr. Josefina Aleu

Cadiz University
orcid

Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 May 2002 in Journal of Chemical Ecology
Verified
Journal Article
Closed access
PDF file
ACA. J. Colmenares
A. J. Colmenares
Josefina AleuJosefina Aleu
Josefina Aleu
Rosa M. Durán-PatrónRosa M. Durán-Patrón
Rosa M. Durán-Patrón
ICIsidro G Collado
Isidro G Collado
RHRosario Hernández-Galan
Rosario Hernández-Galan

1 March 2011 in Fungal Genetics and Biology
Verified
Journal Article
Closed access
ATAnamariela Tijerino
Anamariela Tijerino
Rosa Elena CardozaRosa Elena Cardoza
Rosa Elena Cardoza
Javier MoragaJavier Moraga
Javier Moraga
MMMónica G. Malmierca
Mónica G. Malmierca
FVFrancisca Vicente
Francisca Vicente
Rosa HermosaRosa Hermosa
Rosa Hermosa

1 August 2009 in Current Organic Chemistry
Verified
Journal Article
Closed access
Cristina Pinedo-RivillaCristina Pinedo-Rivilla
Cristina Pinedo-Rivilla
Josefina AleuJosefina Aleu
Josefina Aleu
ICIsidro G Collado
Isidro G Collado
One of the major problems facing the industrialized world today is the contamination of soils, ground water, sediments, surfacewater and air with hazardous and toxic chemicals. The application of microorganisms which degrade or transform hazardous organic contaminants to less toxic compounds has become increasingly popular in recent years. This review, with approximately 300 references covering the period 2005-2008, describes the use of fungi as a method of bioremediation to clean up environmental pollutants.

14 March 2011 in Journal of Natural Products
Verified
Journal Article
Closed access
AHAhlem Hamdache
Ahlem Hamdache
ALAhmed Lamarti
Ahmed Lamarti
Josefina AleuJosefina Aleu
Josefina Aleu
ICIsidro G Collado
Isidro G Collado

18 January 2022 in Marine Drugs
Verified
Journal Article
Open access
PDF file
Cristina Pinedo-RivillaCristina Pinedo-Rivilla
Cristina Pinedo-Rivilla
Josefina AleuJosefina Aleu
Josefina Aleu
Rosa M. Durán-PatrónRosa M. Durán-Patrón
Rosa M. Durán-Patrón
Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors. The ever-increasing number of sequenced microbial genomes has highlighted a discrepancy between the number of gene clusters potentially encoding the production of natural products and the actual number of chemically characterized metabolites for a given microorganism. Homologous and heterologous expression of these biosynthetic genes, which are often silent under experimental laboratory culture conditions, may lead to the discovery of new cryptic natural products of medical and biotechnological interest. Several new genetic and cultivation-based strategies have been developed to meet this challenge. The OSMAC approach (one strain—many compounds), based on modification of growth conditions, has proven to be a powerful strategy for the discovery of new cryptic natural products. As a direct extension of this approach, the addition of chemical elicitors or epigenetic modifiers have also been used to activate silent genes. This review looks at the structures and biological activities of new cryptic metabolites from marine-derived microorganisms obtained using the OSMAC approach, the addition of chemical elicitors, and enzymatic inhibitors and epigenetic modifiers. It covers works published up to June 2021.

4 February 1999 in Journal of Natural Products
Verified
Journal Article
Closed access
Josefina AleuJosefina Aleu
Josefina Aleu
JHJames R. Hanson
James R. Hanson
RHRosario Hernández-Galan
Rosario Hernández-Galan
ICIsidro G Collado
Isidro G Collado