Gyu Ri Kim, Ph.D., Eun-Young Kim, Ph.D., Si Hyun Kim, Ph.D., Hae Kyung Lee, M.D., Jaehyeon Lee, M.D., Jong Hee Shin, M.D., Young Ree Kim, M.D., Sae Am Song, M.D., Joseph Jeong, M.D., Young Uh, M.D., Yu Kyung Kim, M.D., Dongeun Yong, M.D., Hyun Soo Kim, M.D., Sunjoo Kim, M.D., Young Ah Kim, M.D., Kyeong Seob Shin, M.D., Seok Hoon Jeong, M.D., Namhee Ryoo, M.D., and Jeong Hwan Shin, M.D.. Ann Lab Med 2023;43:45-54. https://doi.org/10.3343/alm.2023.43.1.45

Park DC, et al. Ann Lab Med. 2019 Nov;39(6):537-544. https://doi.org/10.3343/alm.2019.39.6.537

We investigated mortality and predictors of mortality due to intensive care unit-associated candidemia (ICUAC) versus non-ICUAC by Candida species. This study included all candidemia cases in 11 hospitals from 2017 to 2018 in South Korea. The all-cause mortality rates in all 370 patients with ICUAC were approximately twofold higher than those in all 437 patients with non-ICUAC at 7 days (2.3-fold, 31.1%/13.3%), 30 days (1.9-fold, 49.5%/25.4%), and 90 days (1.9-fold, 57.8%/30.9%). Significant species-specific associations with 7- and 30-day ICUAC-associated mortality were not observed. Multivariate analysis revealed that ICU admission was an independent predictor of Candida glabrata (OR, 2.07–2.48) and Candida parapsilosis-associated mortality (OR, 6.06–11.54). Fluconazole resistance was a predictor of C. glabrata-associated mortality (OR, 2.80–5.14). Lack (less than 3 days) of antifungal therapy was the strongest predictor of 7-day mortality due to ICUAC caused by Candida albicans (OR, 18.33), Candida tropicalis (OR, 10.52), and C. glabrata (OR, 21.30) compared with 30- and 90-day mortality (OR, 2.72–6.90). C. glabrata ICUAC had a stronger association with lack of antifungal therapy (55.2%) than ICUAC caused by other species (30.6–36.7%, all p < 0.05). Most predictors of mortality associated with ICUAC were distinct from those associated with non-ICUAC and were mediated by Candida species.

Yu Jeong Choi, M.D., Young Ah Kim, M.D., Kim Junglim, B.D., Seok Hoon Jeong, M.D., Jong Hee Shin, M.D., Kyeong Seob Shin, M.D., Jeong Hwan Shin, M.D., Young Ree Kim, M.D., Hyun Soo Kim, M.D., Young Uh, M.D., and Nam Hee Ryoo, M.D.. Ann Lab Med 2023;43:196-9. https://doi.org/10.3343/alm.2023.43.2.196

Si Hyun Kim, Ph.D., Gyung-Hye Sung, Ph.D., Eun Hee Park, Ph.D., In Yeong Hwang, Ph.D., Gyu Ri Kim, Ph.D., Sae Am Song, M.D., Hae Kyung Lee, M.D., Young Uh, M.D., Young Ah Kim, M.D., Seok Hoon Jeong, M.D., Jong Hee Shin, M.D., Kyeong Seob Shin, M.D., Jaehyeon Lee, M.D., Joseph Jeong, M.D., Young Ree Kim, M.D., Dongeun Yong, M.D., Miae Lee, M.D., Yu Kyung Kim, M.D., Nam Hee Ryoo, M.D., Seungok Lee, M.D., Jayoung Kim, M.D., Sunjoo Kim, M.D., Hyun Soo Kim, M.D., and Jeong Hwan Shin, M.D.. Ann Lab Med 2022;42:268-73. https://doi.org/10.3343/alm.2022.42.2.268