In recent years, it has been widely accepted that transcription factor 7-like 2 (TCF7L2) is associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups, especially its single nucleotide polymorphisms of rs7903146C/T, rs12255372G/T and rs290487T/C. However, the results previously obtained in Chinese Han population are often inconsistent. For clearing this issue, herein we performed meta-analysis based on the reports that can be found to assess the association. In the meta-analysis, Odds ratio (OR) and 95% confidence interval (95% CI) were calculated with random-effect model or fixed-effect model based on the heterogeneity analysis. The quality of included studies was evaluated by using the Newcastle-Ottawa Scale. The sensitivity analysis was used to confirm the reliability and stability of the meta-analysis. In total, 20 case-control studies with 9122 cases of T2DM and 8017 controls were included. Among these case-control studies, we selected 13 ones on rs7903146 C/T, 5 ones on rs12255372 G/T, 8 ones on rs290487 T/C. The results indicated that rs7903146C/T polymorphism was significantly associated with T2DM (T vs. C, OR = 1.73, 95% CI = 1.39–2.16). There was no evidence that rs12255372G/T and rs290487T/C polymorphisms increased T2DM risk (T vs. G, OR = 1.77, 95% CI = 0.88–3.56; C vs. T, OR = 1.08, 95% CI = 0.93–1.25). Subgroup analysis of different regions proved the relationship between rs7903146C/T polymorphism and T2DM risk in both the northern and the southern China. The association of rs290487 with T2DM was affected by body mass index, whereas the association of rs7903146 and rs290487 with T2DM was influenced neither by age nor by sex. In conclusion, this study indicated that the rs7903146C/T polymorphism of the TCF7L2 gene had a significant effect on T2DM risk in Chinese Han population, with rs12255372G/T and rs290487T/C polymorphisms showing no significant effect.

The purpose of the study was to investigate the nursing students' levels of the knowledge, willingness, and attitudes toward first aid behavior as bystanders in road traffic accident and the related factors. A total of 475 nursing students were recruited by convenience choosing in Tianjin University of Traditional Chinese Medicine. The nursing students' self-efficacy, core self-evaluation, knowledge, willingness and attitudes toward first aid behavior as bystanders in traffic accidents were investigated with a self-designed questionnaire. The scores of knowledge, willingness, and attitudes toward first aid behavior in traffic accident trauma were 7.51 ± 1.93, 15.54 ± 5.03, and 7.73 ± 1.56, respectively. Students who once gained training of first aid showed lower levels of attitude toward first aid behavior than those untrained (t = -2.345, P = 0.019). It was found that self-efficacy was correlated to the knowledge (r = 0.150, P < 0.001), willingness (r = 0.182, P < 0.004) and attitudes toward behavior of the first aid (r = 0.371, P < 0.001) among nursing students. Core self-evaluation was correlated to knowledge (r = 0.193, P < 0.001) and attitudes toward behavior of the first aid (r = 0.199, P < 0.001). The first aid knowledge among nursing students was not satisfactory. The study suggested that an unsustainable short first-aid training program may bring negative effects. Countermeasures should be taken to ensure both quality and continuity of first aid training. Meanwhile, more attention should be paid to improving the self-efficacy and core self-evaluation of the nursing students.

Background: Prevention of Alzheimer's disease (AD) with Vitamin D (V_D) supplementation has been studied widely, but the results in the literature are very conflicting. The Study Question: Can V_D supplementation really prevent AD? Study Design: The literature was searched from PubMed, Cochrane library, Web of Science, and EMBASE to identify relevant randomized clinical trials (RCTs). The titles and abstracts were evaluated independently by 2 of the authors. Results: Nine RCTs with 2345 participants were included. In the meta-analysis, we found no significant difference in the Mini-Mental State Examination, verbal fluency, verbal memory, visual ability, and attention scores between the V_D intervention group and comparison group [standardized mean difference (SMD) = −0.05, 95% confidence interval (CI) = −0.51 to 0.41; SMD = −0.01, 95% CI = −0.13 to 0.11; SMD = 0.12, 95% CI = −0.45 to 0.69; SMD = 0.42, 95% CI = −0.15 to 1.00; and SMD = 0.01, 95% CI = −0.24 to 0.27, respectively]. In subgroup analysis, we found that the intervention with only V_D or plus calcium, follow-up duration, and baseline 25(OH)D levels did not explain the cause for high heterogeneity. Conclusions: Overall, the current evidence did not support the beneficial effect of V_D supplement to prevent AD. High quality RCTs and further studies are needed to clarify the effects of V_D supplementation on preventing AD.

Background: As the population ages, the subject of elder abuse has become more prominent, with psychological abuse of older people being particularly prevalent. This leads to a higher incidence of anxiety, depression, and other psychological problems among older people, reducing their quality of life, and even jeopardizing their safety.Methods: A cross-sectional questionnaire survey was conducted to investigate psychological abuse among home-dwelling older people in Northern China and its influencing factors. Participants were surveyed using a demographic questionnaire, activities of daily living (ADL), family adaptability and cohesion evaluation scale (FACES), and elder psychological abuse scale. The factors impacting psychological abuse were examined using binary logistic regression.Results: A total of 465 home-dwelling older people participated in the study, with an effective response rate of 97.89%. The median item score of psychological abuse was 20 (IQR: 18–22), activities of daily living was 15 (IQR: 14–17), and family adaptability and cohesion was 96 (IQR: 86–105). Binary logistic regression analysis indicated that the factors affecting psychological abuse among home-dwelling older people were residence in rural areas (OR = 3.487, 95% CI = 2.121–5.732), monthly income ≥ 3,501 (OR = 0.342, 95% CI = 0.119–0.987), had chronic diseases (OR = 2.202, 95% CI = 1.356–3.576), and FACES (OR = 0.955, 95% CI = 0.936–0.974) were the factors that influenced the prevalence of psychological abuse.Conclusion: In Northern China, the level of psychological abuse among older people is low. It is associated with residence, monthly income, chronic diseases, and family adaptability and cohesion. Further studies are required to understand the underlying causes and develop effective interventions to reduce psychological abuse and ensure a comfortable old life for older Chinese people.

Background: In nursing homes, elder neglect has come to the forefront. Currently, few studies have examined the impact of personal and organizational factors of geriatric nursing assistants on elder neglect. From the perspective of geriatric nursing assistants, this study aims to explore the current situation and influencing factors of elder neglect in Chinese nursing homes.Methods: A convenience sampling method was used to recruit 412 geriatric nursing assistants from 50 nursing homes in China. Participants were surveyed using a demographic questionnaire, the Elder Neglect Scale for Geriatric Nursing Assistants, the General Self-Efficacy Scale (GSES), and the Proactive Personality Scale (PPS). Spearman correlation analysis and multiple linear regression were used to analyze the factors influencing elder neglect.Results: Geriatric nursing assistants scored a median of 74 out of 85 on the Elder Neglect Scale. Multiple linear regression analyses showed that the main personal factors influencing geriatric nursing assistants’ elder neglect were general self-efficacy (β = 0.312), proactive personality (β = 0.180), and advanced qualification (β = 0.084), while the main organizational factors included monthly salary ≤ 1,900 RMB (β = −0.256), no regular training after induction (β = −0.253), and the number of days off per month (3–4 days off β = 0.192, ≥ 5 days off β = 0.101).Conclusion: Although geriatric nursing assistants are at low levels of elder neglect, it remains a cause for concern. Among the personal factors, geriatric nursing assistants who possessed proactive personalities, high self-efficacy and advanced qualifications, exhibited low levels of elder neglect. Among the organizational factors, those who possessed a high number of days off per month portrayed low levels of elder neglect. Conversely, those who received low monthly salaries and no regular training after induction portrayed high levels of elder neglect. To reduce the risk of elder neglect, nursing homes should give due consideration to candidates’ self-efficacy and proactive personality traits when recruiting, and focus on fostering these personality traits in their employees during their work. In addition, strengthening regular training for geriatric nursing assistants, optimizing the salary structure, and arranging rest days in a reasonable manner are also necessary measures.