Mechanistic insight is achieved only when experiments are employed to test formal or computational models. Furthermore, in analogy to lesion studies, phantom perception may serve as a vehicle to understand the fundamental processing principles underlying healthy auditory perception. With a special focus on tinnitus—as the prime example of auditory phantom perception—we review recent work at the intersection of artificial intelligence, psychology and neuroscience. In particular, we discuss why everyone with tinnitus suffers from (at least hidden) hearing loss, but not everyone with hearing loss suffers from tinnitus. We argue that intrinsic neural noise is generated and amplified along the auditory pathway as a compensatory mechanism to restore normal hearing based on adaptive stochastic resonance. The neural noise increase can then be misinterpreted as auditory input and perceived as tinnitus. This mechanism can be formalized in the Bayesian brain framework, where the percept (posterior) assimilates a prior prediction (brain’s expectations) and likelihood (bottom-up neural signal). A higher mean and lower variance (i.e. enhanced precision) of the likelihood shifts the posterior, evincing a misinterpretation of sensory evidence, which may be further confounded by plastic changes in the brain that underwrite prior predictions. Hence, two fundamental processing principles provide the most explanatory power for the emergence of auditory phantom perceptions: predictive coding as a top-down and adaptive stochastic resonance as a complementary bottom-up mechanism. We conclude that both principles also play a crucial role in healthy auditory perception. Finally, in the context of neuroscience-inspired artificial intelligence, both processing principles may serve to improve contemporary machine learning techniques.

We introduce the Generalized Discrimination Value (GDV) that measures, in a non-invasive manner, how well different data classes separate in each given layer of an artificial neural network. It turns out that, at the end of the training period, the GDV in each given layer L attains a highly reproducible value, irrespective of the initialization of the network's connection weights. In the case of multi-layer perceptrons trained with error backpropagation, we find that classification of highly complex data sets requires a temporal reduction of class separability, marked by a characteristic 'energy barrier' in the initial part of the GDV(L) curve. Even more surprisingly, for a given data set, the GDV(L) is running through a fixed 'master curve', independently from the total number of network layers. Finally, due to its invariance with respect to dimensionality, the GDV may serve as a useful tool to compare the internal representational dynamics of artificial neural networks with different architectures for neural architecture search or network compression; or even with brain activity in order to decide between different candidate models of brain function.

Modern Machine learning techniques take advantage of the exponentially rising calculation power in new generation processor units. Thus, the number of parameters which are trained to solve complex tasks was highly increased over the last decades. However, still the networks fail - in contrast to our brain - to develop general intelligence in the sense of being able to solve several complex tasks with only one network architecture. This could be the case because the brain is not a randomly initialized neural network, which has to be trained from scratch by simply investing a lot of calculation power, but has from birth some fixed hierarchical structure. To make progress in decoding the structural basis of biological neural networks we here chose a bottom-up approach, where we evolutionarily trained small neural networks in performing a maze task. This simple maze task requires dynamic decision making with delayed rewards. We were able to show that during the evolutionary optimization random severance of connections leads to better generalization performance of the networks compared to fully connected networks. We conclude that sparsity is a central property of neural networks and should be considered for modern Machine learning approaches.

Noise is generally considered to harm information processing performance. However, in the context of stochastic resonance, noise has been shown to improve signal detection of weak sub- threshold signals, and it has been proposed that the brain might actively exploit this phenomenon. Especially within the auditory system, recent studies suggest that intrinsic noise plays a key role in signal processing and might even correspond to increased spontaneous neuronal firing rates observed in early processing stages of the auditory brain stem and cortex after hearing loss. Here we present a computational model of the auditory pathway based on a deep neural network, trained on speech recognition. We simulate different levels of hearing loss and investigate the effect of intrinsic noise. Remarkably, speech recognition after hearing loss actually improves with additional intrinsic noise. This surprising result indicates that intrinsic noise might not only play a crucial role in human auditory processing, but might even be beneficial for contemporary machine learning approaches.

Reliable determination of sensory thresholds is the holy grail of signal detection theory. However, there exists no assumption-independent gold standard for the estimation of thresholds based on neurophysiological parameters, although a reliable estimation method is crucial for both scientific investigations and clinical diagnosis. Whenever it is impossible to communicate with the subjects, as in studies with animals or neonates, thresholds have to be derived from neural recordings or by indirect behavioral tests. Whenever the threshold is estimated based on such measures, the standard approach until now is the subjective setting—either by eye or by statistical means—of the threshold to the value where at least a “clear” signal is detectable. These measures are highly subjective, strongly depend on the noise, and fluctuate due to the low signal-to-noise ratio near the threshold. Here we show a novel method to reliably estimate physiological thresholds based on neurophysiological parameters. Using surrogate data we demonstrate that fitting the responses to different stimulus intensities with a hard sigmoid function, in combination with subsampling, provides a robust threshold value as well as an accurate uncertainty estimate. This method has no systematic dependence on the noise and does not even require samples in the full dynamic range of the sensory system. We prove that this method is universally applicable to all types of sensory systems, ranging from somatosensory stimulus processing in the cortex to auditory processing in the brain stem.

Up to now, modern machine learning (ML) has been based on approximating big data sets with high-dimensional functions, taking advantage of huge computational resources. We show that biologically inspired neuron models such as the leaky-integrate-and-fire (LIF) neuron provide novel and efficient ways of information processing. They can be integrated in machine learning models and are a potential target to improve ML performance. Thus, we have derived simple update rules for LIF units to numerically integrate the differential equations. We apply a surrogate gradient approach to train the LIF units via backpropagation. We demonstrate that tuning the leak term of the LIF neurons can be used to run the neurons in different operating modes, such as simple signal integrators or coincidence detectors. Furthermore, we show that the constant surrogate gradient, in combination with tuning the leak term of the LIF units, can be used to achieve the learning dynamics of more complex surrogate gradients. To prove the validity of our method, we applied it to established image data sets (the Oxford 102 flower data set, MNIST), implemented various network architectures, used several input data encodings and demonstrated that the method is suitable to achieve state-of-the-art classification performance. We provide our method as well as further surrogate gradient methods to train spiking neural networks via backpropagation as an open-source KERAS package to make it available to the neuroscience and machine learning community. To increase the interpretability of the underlying effects and thus make a small step toward opening the black box of machine learning, we provide interactive illustrations, with the possibility of systematically monitoring the effects of parameter changes on the learning characteristics.