The transformation of the labour market is a significant challenge for sustainable regional development, especially in countries with pronounced socioeconomic inequalities. This study aims to analyse the spatial disparities in the Bulgarian labour market at the regional level (NUTS 3, districts) for the period of 2021–2024, combining descriptive spatial analysis, multidimensional cluster analysis, and Local Indicator of Spatial Association (Local Moran’s I-LISA). The analysis is based on three key indicators: employment rates, unemployment rates, and the relative wage index, calculated against the national average. The results of the descriptive analysis reveal clear spatial imbalances, with low labour income persisting in many districts despite relatively high employment rates. The cluster analysis identifies four types of labour markets with specific socioeconomic profiles, confirming that the spatial disparities are a result of specific combinations of indicators and economic specialisation at the regional level. The LISA analysis further reveals the existence of spatially stable cores of vulnerability and local spatial anomalies that highlight the importance of regional context and spatial proximity. The results indicate the need for a spatially differentiated approach in regional policies in line with the objectives of SDG8, SDG10, the European Pillar of Social Rights, and the EU’s cohesion policy.