The mineralogical composition, textural characteristics, and uranium occurrence of sandstone-hosted uranium ores significantly influence the leaching performance during in situ recovery. This study investigates ore samples from the Zhenyuan uranium deposit, China, utilizing SEM, EPMA, XRD, and XRF to characterize their texture and mineralogy. Combined with thin-section leaching tests, batch stirring experiments, and pressurized column leaching experiments, the leaching behavior of pitchblende, associated gangue minerals, and the whole rocks were evaluated. The results indicate that: Uranium mainly occurs as nano-spherical and film-like pitchblende distributed along the edges of detrital grains and Ti-oxides. Minor uranium is incorporated into Ti-oxides and dolomite lattices via isomorphic substitution or adsorbed by chlorite. Under CO₂ + O₂ leaching conditions, pitchblende was almost completely dissolved, while U-bearing Ti-oxides experienced slight corrosion. Dolomite underwent partial dissolution, providing bicarbonate ions and improving rock permeability. Pyrite dissolution was limited during the early stage of leaching. The high dolomite content, low clay abundance, favorable pore structure, and easily leachable pitchblende suggest that the Zhenyuan deposit is well suited for CO₂ + O₂ in situ recovery. Increasing CO₂ pressure is recommended to enhance dolomite dissolution and improve uranium recovery efficiency.