Background/Objectives: Abnormal general movements (GMs) in high-risk infants are among the most sensitive early predictors of cerebral palsy (CP) and other neurodevelopmental disorders. This study described changes in the quality of GMs over time in high-risk infants who received the Early Intensive Stojčević–Polovina Rehabilitation Method (EIR–SPM). The EIR–SPM is a rehabilitation method designed for children with CP, those at risk of developing CP, and children with other developmental disabilities. In high-risk infants, it is initiated within the first three months of corrected age, preferably while writhing movements (WMs) are still present. Methods: This study was conducted in eight high-risk infants with abnormal WMs and structural brain injury. The EIR–SPM was initiated between 41 and 47 weeks postmenstrual age (PMA) and was applied until 60 weeks PMA. Prechtl’s General Movements Assessment (GMA), the Detailed GM score, and the Motor Optimality Score–Revised (MOS–R) were assessed. Results: During the writhing period, two infants showed a poor repertoire (PR) pattern and six showed a cramped–synchronized (CS) pattern of GMs; at follow-up, three showed PR, and five showed CS. During the fidgety period, two infants showed normal fidgety movements (F+), two sporadic fidgety movements (sFM), one infant showed abnormal fidgety movements (aFM), and three showed absent fidgety movements (F−) at the first assessment, while at the second assessment, three infants showed F+, two sFM, one aFM, and two F−. The median Detailed GM score increased from 12 (range 11–17) to 13.5 (range 11–19; p = 0.068). The median MOS–R increased from 17.0 (range 12–24) to 19.5 (range 17–27) between the two fidgety assessments (p = 0.027). Conclusions: Improvements in motor repertoire, reflected by increased MOS–R scores, were observed during the EIR–SPM initiated in the writhing period. Larger controlled studies are needed to confirm these preliminary observations.

Background: Global developmental delay (GDD) affects multiple domains of early childhood development, including gross motor, cognitive and communication skills. Early, intensive, family-centered rehabilitation is considered key to optimizing functional outcomes in affected children. Case Presentation: We report a female child with GDD who began rehabilitation at our institution at 15 months of age, presenting with generalized hypotonia with superimposed fluctuating episodes of hypertonia, poor postural control, absent independent sitting, markedly reduced spontaneous motor activity, and associated cognitive and communication delay. Brain MRI at 7 months showed no parenchymal abnormality, with mildly enlarged extracerebral cerebrospinal fluid spaces and ventricular system. The metabolic and genetic evaluation performed so far, including microarray/MLPA-based screening for common microdeletion syndromes and SMN1/SMN2 genotyping, has not identified a specific underlying etiology. Diagnostic work-up is ongoing. Rehabilitation was delivered as a comprehensive, multidomain program; this report focuses specifically on the child’s motor progression. Intervention: The child underwent the Early Intensive Stojčević-Polovina Rehabilitation Method (EIR-SPM), a high-intensity, continuous approach for children with cerebral palsy, at-risk infants, and other developmental disabilities, built on parental education enabling home-based continuity of therapy. Rehabilitation focus is selected according to the child’s optimal developmental stage—the milestone showing the least abnormal movement patterns and muscle tone—rather than chronological age, with positions progressively adjusted following the trajectory of typical motor development described by Vojta. Results: Gross motor function, monitored using the Gross Motor Function Measure–88 (GMFM-88) at four assessment points from 15 months to 6 years 6 months of age, improved progressively from 10.8% to 48.9%, 64.7%, and finally 73.9%. The child achieved independent kneeling, reciprocal crawling, independent sitting in all positions, independent standing and assisted stepping. Conclusions: In this child with GDD of undetermined etiology, more than five years of intensive, family-centered rehabilitation according to the EIR-SPM were accompanied by substantial and sustained gains in gross motor function and functional independence. This report suggests that meaningful progress remains achievable even when rehabilitation begins later than the period considered optimal within the EIR-SPM framework, and that a family-centered structure may be what makes therapy of this intensity and duration sustainable.