Music therapy has been widely used in medical practices, demonstrating positive effects on diverse medical procedures. In the context of labor pain management, evidence suggests that music can positively influence pain perception and overall well-being during labor, serving as a distraction and stress reducer. This systematic review and meta-analysis aim to comprehensively evaluate the impact of music therapy on labor pain in primigravida women during vaginal delivery. Following PRISMA guidelines, a thorough literature search was conducted in Google Scholar, PubMed, and Cochrane Central Register of Controlled Trials up to November 2023. Nine randomized control trials (RCTs) met the inclusion criteria, involving primigravida women undergoing vaginal delivery with music therapy intervention. Quality assessment was performed using the Cochrane Risk of Bias assessment tool. A meta-analysis of the fixed effects was performed using mean differences (MD). Pooled analysis of Visual Analog Scale (VAS) scores revealed statistically significant reductions in pain intensity during latent (MD: − 0.73; 95% CI − 1.01; − 0.45); during the active phase (MD: − 0.56; 95% CI − 1.06; − 0.07) and the second stage (MD: − 0.69; 95% CI − 0.85; − 0.54). The findings indicated no statistically significant variances related to the integration of music therapy in addressing anxiety, both in the latent phase (MD: − 0.88; 95% CI − 1.86; -2.02) and the active phase of labor (MD: -0.30; 95% CI − 1.74; 1.13). In conclusion, the collective evidence presented in this systematic review underscores the potential of music, especially for women giving for the first time. in mitigating labor pain and anxiety across different stages, offering a holistic approach to enhance the overall childbirth experience for women.

Introduction: Giant Serpentine Aneurysms (GSA) are a rare subgroup of complex intracranial vascular anomalies characterized by unusually large and convoluted structures within cerebral arteries. This systematic review examines the historical context, clinical presentations, diagnostic methodologies, and evolving treatments specific to GSAs. Its goal is to advance patient care strategies and outcomes within this intricate neurovascular domain. Methods: Research encompassing patients diagnosed with GSAs was gathered from PubMed, Google Scholar, and Web of Science. Only comprehensive human studies published in English were considered, using search terms like giant serpentine aneurysm, thrombosed aneurysm, bypass, and angiography. Data regarding patient age, gender, symptoms upon presentation, treatments, recovery duration, and outcomes were systematically documented. Result: This analysis of 83 patients with GSA found the middle cerebral artery as the most common site (39.8%). Headaches (54.2%) and visual issues (9.8%) prevailed as symptoms. Seizures correlated with more post-op problems. Females encountered more neurological issues post-surgery (46.4%). Treatment methods varied by location but didn’t significantly affect age or hospital stay length. Conclusion: Early recognition and intervention are crucial for mitigating neurological deficits and improving patient prognosis in GSAs. Expanded research and awareness are needed for definitive diagnostic protocols and treatment guidelines.

Background and Aims: Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and inflammatory skin conditions such as urticaria is still being explored. The review aims to provide an overview of the current knowledge about chronic urticaria, elaborating on the impact of poor sleep quality on QoL of patients with urticaria, with a focus on their emotional well‐being. Methods: The review explores potential mechanisms linking chronic urticaria and sleep disturbances, such as persistent itching and discomfort, the release of inflammatory mediators, systemic inflammation, psychological factors, and effects of medication. Results: The review finds that sleep disturbances have a significant impact on chronic urticaria. It identifies several potential mechanisms linking the two conditions, including persistent symptoms, inflammatory processes, psychological factors, and medication effects. Treatment approaches include a combination of pharmacological and nonpharmacological interventions. Conclusion: The article emphasizes the significance of recognizing the impact of sleep disturbances on chronic urticaria. It lays the groundwork for future research to expand our understanding of this association, ultimately leading to improved management strategies and improved QoL for affected individuals.

Background/Objectives: In Lebanon, the economic crisis since 2019 has severely strained healthcare infrastructure, yet its impact on cancer treatment adherence remains incompletely characterized. This study assessed factors associated with treatment delay and regimen modification to identify barriers to optimal cancer care among Lebanese patients. Methods: This multicenter, cross-sectional study was conducted in five tertiary hospitals in Beirut, Lebanon, between 13 June 2024, and 27 June 2025. Demographic, clinical and treatment data were collected via a structured questionnaire. Bivariate and multivariable binary logistic regression analyses were performed to identify independent predictors of treatment delay (>2 weeks) and incomplete treatment regimens. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) are reported. Results: A total of 244 patients were enrolled in the study. The study population was predominantly female (59.0%) and aged ≥60 years (60.2%). Advanced disease was common, with 50.4% of patients presenting with stage IV disease. Financial vulnerability was widespread: 72.6% reported monthly household incomes below USD 1000, 88.1% reported a decline in income due to the economic crisis, and 39.3% relied on unstable income sources. Overall, 52.5% of patients experienced treatment initiation delays, and 9.0% received incomplete or dose-reduced regimens. On multivariable analysis, reliance on unfixed income independently predicted treatment delay (aOR 2.55, 95% CI 1.42–4.59; p = 0.002), lack of health insurance (aOR 1.91, 95% CI 1.08–3.39; p = 0.026) and pre-treatment surgical costs also increased the odds of delay (aOR 9.03, 95% CI 2.57–31.7; p = 0.001). For incomplete treatment, unfixed income remained an independent predictor (aOR 2.09, 95% CI 1.16–5.79; p = 0.015). A lack of insurance (aOR 5.62, 95% CI 1.22–25.9; p = 0.027) and high laboratory costs (>USD 150 per session) were also associated with incomplete regimens (aOR 1.62, 95% CI 1.02–2.57; p = 0.041). Conclusions: In Lebanon’s crisis context, financial instability was a key factor associated with deviations in cancer treatment. These findings highlight the need for strengthened insurance coverage and subsidization of diagnostic and treatment-related costs to ensure timely and continuous oncologic care.