Spent coffee grounds (SCGs) are abundant byproducts generated during coffee processing that are unsuitable for storage and subsequent value-added utilization owing to their high moisture content and water activity (a_w). This study investigated the effects of different infrared power levels (800, 900, and 1000 W) on drying kinetics, product quality, and energy efficiency to determine the preferred drying parameters for SCGs. The initial moisture content and a_w of SCGs were 63.56% (wet basis) and 0.95, respectively. To enhance mechanistic understanding, the drying data were fitted to four mathematical models, with the Midilli and Page models providing the best fit (R² > 0.99). Drying experiments were conducted under a sample thickness of 0.7 cm and a loading of 500 g, with a final moisture content of <10% as the drying endpoint. The results showed that as infrared power increased, drying time decreased from 30 to 24 min and the drying rate significantly increased from 10.32 to 12.77 g H₂O/min (p < 0.05). The drying process was mainly characterized by a falling-rate period, with the effective moisture diffusivity ranging from 0.97 to 1.15 × 10⁻⁸ m²/s and increasing with rising power, indicating that internal moisture diffusion was the dominant drying mechanism. The final a_w of each treatment group was ≤0.60, indicating good storage stability. Color analysis showed that the color differences in treatments at higher power levels (900 W and 1000 W) were significantly lower than those at lower ones (p < 0.05). While the specific energy consumption (SEC) showed a marginal decrease from 5.80 to 5.68 kWh/kg at higher power, a comprehensive evaluation of drying efficiency, quality characteristics, and energy consumption indicated that 1000 W was the preferred infrared drying power under the conditions employed in this study. These results confirm that infrared drying is an efficient stabilization method with strong potential for rapid stabilization of food processing byproducts.

MRNA vaccines are a relevant approach in cancer immunotherapy, using messenger RNA to induce immune responses against tumor-associated antigens. In this review, BNT111 and BNT122 are compared as representative off-the-shelf and personalized models. BNT111 is a fixed mRNA vaccine that has demonstrated significant antitumor efficacy against shared melanoma antigens, particularly when combined with immune checkpoint inhibitors. It allows a standardized production via in vitro transcription (IVT) in a cell-free system. Conversely, BNT122 is a personalized vaccine designed to match an individual’s tumor mutations by targeting patient-specific neoantigens to elicit more robust immune responses. It has significant suitability in the adjuvant setting to target minimal residual disease. Despite favorable safety and immunogenicity, the effectiveness of these vaccines is influenced by various factors, including tumor heterogeneity, differences in antigen expression, off-target effects on mRNA-LNP distribution, molecular instability, and complex manufacturing constraints. Neither approach can be directly considered as the definitive optimal vaccine. A comprehensive analysis of their strengths and limitations is vital for a balanced and objective future research direction. Collectively, this emphasizes the need for further improvements in vaccine design and strategies, prioritizing high-quality, safe, and accessible treatments for every cancer-based patient and ensuring their successful integration into healthcare.

This scoping review evaluates the role of vector-associated dissemination in contaminating the Philippine food supply chain with antimicrobial-resistant (AMR) Salmonella, an emerging infectious disease threat, using a One Health perspective to map the mechanisms through which insects and rodents bridge environmental reservoirs to human food systems. This scoping review was conducted and reported in accordance with the PRISMA-ScR guidelines. From 1969 records identified through systematic database searches, 52 studies met the inclusion criteria. These comprised 21 primary Philippine studies, 28 non-Philippine studies (including ASEAN-based historical baseline reports), and 3 policy/gray literature studies, prioritized to reflect tropical ecological and agricultural settings. Results suggest that intensive swine and poultry farming may contribute to the emergence of multidrug resistance (MDR) linked to genes such as bla_TEM and qnr. Evidence suggests that Salmonella persists in environmental matrices, such as manure and irrigation water, and that synanthropic vectors, including Rattus rattus and various fly species, potentially serve as biological and mechanical bridges in transmission. Clinical data reveal an alarming trend toward invasive non-typhoidal salmonellosis (iNTS) showing reduced susceptibility to cephalosporins and fluoroquinolones. Despite these findings, major evidence gaps remain, particularly regarding the prevalence of vector-borne Salmonella in pre-harvest produce. Consequently, mitigation requires a One Health framework that integrates non-antibiotic interventions, pest management to disrupt transmission pathways, and rapid diagnostic tools, such as loop-mediated isothermal amplification (LAMP), to enhance market surveillance.

Soybean residue (Okara), a major by-product of soybean product processing, is highly susceptible to spoilage due to its high moisture content (approximately 78% w.b.), which creates both environmental and resource-related challenges. This study aimed to develop energy-efficient drying technologies and value-added application models to improve its storage stability. The effects of heat pump drying, microwave drying, and two-stage drying on the drying kinetics, energy consumption, and product quality of okara were systematically compared. The experimental results indicated that Heat Pump Drying (HPD) at 65 °C required a prolonged drying time of 360 min. In contrast, Microwave Drying (MWD) at 2.0 W/g significantly accelerated the process, achieving the shortest drying time of 50 min (an 86.1% reduction) and lowering the specific energy consumption (SEC) to 2.2 kWh/kg (a 42.1% energy saving compared to HPD). Meanwhile, the HPD–MWD two-stage drying process offered a balanced alternative, requiring 190 min and reducing thermal risk while maintaining high efficiency. The dried okara powder contained a total dietary fiber content of 47.78%, while its water activity was maintained below 0.60. Dynamic Dew Point Isotherm (DDI) analysis confirmed a critical water activity (a_wc) of 0.66, with mathematical modeling predicting a shelf life of up to 389 days under barrier packaging conditions. In value-added application experiments, muffins containing 10% okara powder achieved sensory scores above 6 on a 9-point scale and demonstrated significantly better flavor acceptability (p = 0.0093). In summary, this study established an efficient drying and value-added application approach for okara, providing a feasible strategy for the circular use and sustainable utilization of agricultural by-products.

Access to safe drinking water remains a global public health concern due to its role in the transmission of infectious diseases. Despite the 20th-century achievement of chlorine-based disinfection, drinking water systems face threats from aging infrastructure, climate-induced stressors, and emerging pathogens that evade traditional treatment. This bibliometric review maps three decades of research on microbial contamination in drinking water systems to explain its historical developments, current knowledge, and important updates. Only original and review articles retrieved on 13 April 2026 were screened for inclusion, requiring a focus on detecting, monitoring, or mitigating microbial contamination in drinking water systems. Analysis of 93 records identified a linear growth pattern, shifting from acute enteric pathogen monitoring to the management of opportunistic pathogens (OPs), antimicrobial resistance (AMR), and disinfection by-products (DBPs). Additionally, traditional fecal indicator bacteria (FIB), such as Escherichia coli, may not fully predict the presence of resilient pathogens protected within biofilms or free-living amoebae (FLA), which serve as environmental reservoirs for infection. To address these limitations, this review presents a conceptualization of waterborne pathogens by proposing formal case definitions and diagnostic criteria for critical contamination events (CCE) and chronic low-level exposure (CLLE). Lastly, knowledge gaps and open research questions relevant to future studies on microbial contamination in drinking water systems were identified and discussed.