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Dr. Peng-Yuan Wang
Oujiang Laboratory
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Representative Publications
View All Publications23 February 2023 in Frontiers in Bioengineering and Biotechnology
Journal Article
QHQian Hu
Qian Hu
QBQihui Bian
Qihui Bian
DRDingchao Rong
Dingchao Rong
LWLeiyun Wang
Leiyun Wang
JSJianan Song
Jianan Song
PWPeng-Yuan Wang
Peng-Yuan Wang +3
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing studies show that the JAK/STAT pathway regulates the downstream signaling of numerous membrane proteins such as such as G-protein-associated receptors, integrins and so on. Mounting evidence shows that the JAK/STAT pathways play an important role in human disease pathology and pharmacological mechanism. The JAK/STAT pathways are related to aspects of all aspects of the immune system function, such as fighting infection, maintaining immune tolerance, strengthening barrier function, and cancer prevention, which are all important factors involved in immune response. In addition, the JAK/STAT pathways play an important role in extracellular mechanistic signaling and might be an important mediator of mechanistic signals that influence disease progression, immune environment. Therefore, it is important to understand the mechanism of the JAK/STAT pathways, which provides ideas for us to design more drugs targeting diseases based on the JAK/STAT pathway. In this review, we discuss the role of the JAK/STAT pathway in mechanistic signaling, disease progression, immune environment, and therapeutic targets.
Journal Article
CTCheng-Han Tsai
Cheng-Han TsaiPWPeng-Yuan Wang
Peng-Yuan WangILI-Chan Lin
I-Chan LinHHHu Huang
Hu HuangGLGuei-Sheung Liu
Guei-Sheung LiuCTChingli Tseng
Chingli TsengOcular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.
1 September 2011 in Acta Biomaterialia
Journal Article
PWPeng-Yuan Wang
Peng-Yuan Wang
Jiashing YuJLJia-Hua Lin
Jia-Hua Lin
Wei-Bor Tsai1 February 2012 in Acta Biomaterialia
Journal Article
10 May 2012 in Advanced Functional Materials
Journal Article
PWPeng-Yuan Wang
Peng-Yuan WangLCLauren R. Clements
Lauren R. Clements
HTHelmut Thissen
Helmut ThissenAJAndrew Jane
Andrew Jane
Wei-Bor TsaiNVNicolas Voelcker
Nicolas Voelcker10 February 2010 in Biotechnology and Bioengineering
Journal Article
About Me
Dr Wang is currently a Principal Investigator at Oujiang Laboratory, China. He received his Ph.D. at the Department of Chemical Engineering, National Taiwan University, in 2011. After his postdoc and lecturer training at Swinburne University in Australia, he started his role as a Principal Investigator at Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS). He was the Director of the Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation from 2020 to 2022.
Dr Wang has been awarded several prestigious awards, including the Discovery Early Career Researcher Award (DECRA), Veski Victoria Fellowship, Vice-Chancellor’s Research Excellence Award, and Australia-China Young Scientists in Australia. He has so far led 10 national grants with research funds of over 3 million USD.
Dr Wang's research focuses on biophysical effects on mammalian cells. In particular, his interests include manipulating stem cell growth, differentiation, and reprogramming using advanced nanobiotechnologies. He has authored over 80 peer-reviewed publications, 3 book chapters, 1 ebook, and applied/issued over 10 patents worldwide. He has served as guest editor and reviewer for more than 20 SCI journals. His works provide an essential framework for understanding biophysics, cell–material interactions, biomaterials, and regenerative medicine.