Breast cancer is one of the most common forms of neoplasia worldwide. The purpose of our observational study was to evaluate the status of HER2 overexpression among new cases of breast neoplasia with an impact on the natural history of breast cancer disease and therapeutic personalization according to staging. This study included 45 breast cancer patients which have an overexpression of HER2 through the mutation of the EGFR-ERBB2 receptor. Immunohistochemical staining was performed on sections of formalin-fixed paraffin-embedded breast tissue. The patients were evaluated demographically and therapeutically in all stages. The post-surgical histopathological examination revealed complete pathological responses in 19 patients and pathological responses with residual disease either at the tumor level or lymphatic or both variants in a percentage of 44% (15 cases). The disease-free interval (DFI) under anti-HER2 therapy was recorded in 41 patients, representing 91% of the study group. Anti-HER2 therapy in any therapeutic stage has shown increased efficiency in blocking these tyrosine kinase receptors, evidenced by the high percentage of complete pathological responses, as well as the considerable percentage (47%) of complete remissions and stationary disease, in relation to the HER2-positive patient group.

Background: Styloid process abnormalities, classically associated with Eagle syndrome, have increasingly been implicated in cerebrovascular events through mechanical interaction with cervical vessels. Methods: This study combined a structured narrative review of the relationship between styloid process anatomy and internal carotid artery dissection with a single-center retrospective observational cohort. Consecutive patients with acute ischemic stroke were evaluated to identify cases of extracranial internal carotid artery dissection, in whom styloid process anatomy, carotid morphology, and potential mechanical triggers were subsequently assessed. The narrative review was supported by a structured PubMed/MEDLINE search and a PRISMA-style study-selection process. No formal meta-analysis was performed, and the institutional cohort did not include an age- and sex-matched control group. Results: The literature search identified 34 eligible reports for the narrative synthesis. Among 1621 consecutive ischemic stroke admissions, 17 patients (1.04%) had extracranial internal carotid artery dissection. Elongated styloid processes (≥30 mm) were identified in 11/17 patients (64.7%), and carotid tortuosity was present in 10/17 patients (58.8%). Several patients had identifiable mechanical or traumatic precipitating factors. Conclusions: Styloid process elongation and carotid tortuosity were frequently observed in patients with extracranial internal carotid artery dissection. These findings support careful assessment of styloid–carotid anatomy in selected patients with carotid dissection. However, the small sample size, retrospective design, and absence of a control group preclude causal inference and require validation in larger controlled studies.