Weisan Chen

Prof. Weisan Chen

orcid

Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2015 in Seminars in Cell & Developmental Biology
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Journal Article
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DGDavid Greening
David Greening
SGShashi K. Gopal
Shashi K. Gopal
RXRong Xu
Rong Xu
RSRichard J. Simpson
Richard J. Simpson
WCWeisan Chen
Weisan Chen

10 September 2020 in Proceedings of the National Academy of Sciences
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Journal Article
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JHJennifer R. Habel
Jennifer R. Habel
TNThi Hoang Oanh Nguyen
Thi Hoang Oanh Nguyen
Carolien Emma van de SandtCarolien Emma van de Sandt
Carolien Emma van de Sandt
JJJennifer Juno
Jennifer Juno
PCPriyanka Chaurasia
Priyanka Chaurasia
KKKatherine Kedzierska
Katherine Kedzierska
Significance: As the recall of CD8 + T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8 + T cells from COVID-19 patients. For two HLA-A*02:01 SARS-CoV-2−specific CD8 + T cell epitopes, we found that, while ex vivo frequencies of responding T cells were approximately fivefold higher than for pre−COVID-19 samples, they were ∼10-fold lower than for influenza or EBV-specific memory CD8 + T cells. Additionally, SARS-CoV-2−specific CD8 + T cells recovered from convalescent COVID-19 patients had an atypically high prevalence of stem cell memory, central memory, and naïve phenotypes. Might this unexpectedly low prevalence of classical effector memory T cells be a negative consequence of the infectious process that could be avoided by prior priming with an appropriately constituted vaccine?

14 July 2021 in Nature Communications
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Ebony MonsonEbony Monson
Ebony Monson
KCK. M. Crosse
K. M. Crosse
MDM. Duan
M. Duan
WCWeisan Chen
Weisan Chen
RORoss O'Shea
Ross O'Shea
Karla HelbigKarla Helbig
Karla Helbig
Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and inter-organelle interactions. However, the role LDs play in antiviral innate immune pathways remains unknown. Here we demonstrate that induction of LDs occurs as early as 2 h post-viral infection, is transient and returns to basal levels by 72 h. This phenomenon occurs following viral infections, both in vitro and in vivo. Virally driven in vitro LD induction is type-I interferon (IFN) independent, and dependent on Epidermal Growth Factor Receptor (EGFR) engagement, offering an alternate mechanism of LD induction in comparison to our traditional understanding of their biogenesis. Additionally, LD induction corresponds with enhanced cellular type-I and -III IFN production in infected cells, with enhanced LD accumulation decreasing viral replication of both Herpes Simplex virus 1 (HSV-1) and Zika virus (ZIKV). Here, we demonstrate, that LDs play vital roles in facilitating the magnitude of the early antiviral immune response specifically through the enhanced modulation of IFN following viral infection, and control of viral replication. By identifying LDs as a critical signalling organelle, this data represents a paradigm shift in our understanding of the molecular mechanisms which coordinate an effective antiviral response.

23 May 2017 in Journal of Translational Medicine
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LLLiang Li
Liang Li
MDMubing Duan
Mubing Duan
WCWeisan Chen
Weisan Chen
AJAn Jiang
An Jiang
XLXiaoming Li
Xiaoming Li
ZLZongfang Li
Zongfang Li
The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis.

25 September 2018 in Cell Death & Disease
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Georgia Atkin-SmithGeorgia Atkin-Smith
Georgia Atkin-Smith
MDMubing Duan
Mubing Duan
WCWeisan Chen
Weisan Chen
Ivan PoonIvan Poon
Ivan Poon
Infection with Influenza A virus (IAV) causes significant cell death within the upper and lower respiratory tract and lung parenchyma. In severe infections, high levels of cell death can exacerbate inflammation and comprise the integrity of the epithelial cell barrier leading to respiratory failure. IAV infection of airway and alveolar epithelial cells promotes immune cell infiltration into the lung and therefore, immune cell types such as macrophages, monocytes and neutrophils are readily exposed to IAV and infection-induced death. Although the induction of cell death through apoptosis and necrosis following IAV infection is a well-known phenomenon, the molecular determinants responsible for inducing cell death is not fully understood. Here, we review the current understanding of IAV-induced cell death and critically evaluate the consequences of cell death in aiding either the restoration of lung homoeostasis or the progression of IAV-induced lung pathologies.

11 December 2019 in Angewandte Chemie International Edition
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TOTze Cin Owyong
Tze Cin Owyong
PSPramod Subedi
Pramod Subedi
JDJieru Deng
Jieru Deng
EHElizabeth Hinde
Elizabeth Hinde
JPJason J Paxman
Jason J Paxman
YHYuning Hong
Yuning Hong