Water is known to be the main deteriorating agent of building geomaterials. Owing to the presence of water, the alteration phenomena observed particularly on limestones are transportation of soluble salts, dissolution of calcite and development of micro-organisms. In restoration works, several chemical treatments can be used, such as biocides to remove existing biofouling and water-repellents to prevent the ingress of water and its deteriorating effects. The aim here was to combine these two properties in one treatment that could be applied at the end of the restoration work and to develop treatments based on natural products and that are safer for the users and the environment. Products with water-repellent and/or anti-colonization properties were developed and tested on a bioclastic limestone both in laboratory and outdoor conditions. They were compared with commercial water-repellents and a preventive anti-colonization treatment. Samples were exposed for 2 years in a forest environment, where the hydrophobicity and the colonization were evaluated every 6 months. In the laboratory, anti-colonization effects were determined through algae growth measurements. The product that confirmed an efficient hydrophobicity and anti-colonization effect will be applied on a restored site to test it under real conditions.