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Dr. Rosa Casas
Institut de Recerca Biomèdica August Pi i Sunyer (IDIBAPS) Barcelona, Spain

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0 Atherosclerosis
0 Cardiovascular Disease
0 Coronary Artery Disease
0 Inflammation
0 Nutrients

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Journal article
Published: 22 July 2021 in Biomedicines
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The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p< 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p< 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.

ACS Style

Mireia Urpi-Sarda; Rosa Casas; Emilio Sacanella; Dolores Corella; Cristina Andrés-Lacueva; Rafael Llorach; Gloria Garrabou; Francesc Cardellach; Aleix Sala-Vila; Emilio Ros; Miguel Ruiz-Canela; Montserrat Fitó; Jordi Salas-Salvadó; Ramon Estruch. The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines 2021, 9, 862 .

AMA Style

Mireia Urpi-Sarda, Rosa Casas, Emilio Sacanella, Dolores Corella, Cristina Andrés-Lacueva, Rafael Llorach, Gloria Garrabou, Francesc Cardellach, Aleix Sala-Vila, Emilio Ros, Miguel Ruiz-Canela, Montserrat Fitó, Jordi Salas-Salvadó, Ramon Estruch. The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines. 2021; 9 (8):862.

Chicago/Turabian Style

Mireia Urpi-Sarda; Rosa Casas; Emilio Sacanella; Dolores Corella; Cristina Andrés-Lacueva; Rafael Llorach; Gloria Garrabou; Francesc Cardellach; Aleix Sala-Vila; Emilio Ros; Miguel Ruiz-Canela; Montserrat Fitó; Jordi Salas-Salvadó; Ramon Estruch. 2021. "The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease." Biomedicines 9, no. 8: 862.

Study protocol
Published: 24 May 2021 in Trials
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Background Fetal growth restriction (FGR) affects 7–10% of all pregnancies resulting in a higher risk of perinatal morbidity and mortality, long-term disabilities, and cognitive impairment. Due to its multifactorial etiology, changes in maternal lifestyle, including suboptimal maternal diet and stress, have increasingly been associated with its prevalence. We present a protocol for the Improving Mothers for a better PrenAtal Care Trial Barcelona (IMPACT BCN), which evaluates two different maternal lifestyle strategies (improved nutrition by promoting Mediterranean diet and stress reduction program based on mindfulness techniques) on perinatal outcomes. The primary objective is to reduce the prevalence of FGR. Secondary aims are to reduce adverse perinatal outcomes and to improve neurodevelopment and cardiovascular profile in children at 2 years of age. Methods A randomized parallel, open-blind, single-center trial following a 1:1:1 ratio will select and randomize high-risk singleton pregnancies for FGR (N=1218), according to the criteria of the Royal College of Obstetricians and Gynaecologists (19.0–23.6 weeks’ gestation), into three arms: Mediterranean diet, mindfulness-based stress reduction program, and usual care without any intervention. Compliance to the interventions will be randomly tested in 30% of participants with specific biomarkers. Maternal socio-demographic, clinical data, biological samples, and lifestyle questionnaires will be collected at enrollment and at the end of the interventions (34.0–36.6 weeks’ gestation), together with a fetoplacental ultrasound and magnetic resonance. Fetoplacental biological samples and perinatal outcomes will be recorded at delivery. Postnatal follow-up is planned up to 2 years of corrected age including neurodevelopmental tests and cardiovascular assessment. Intention-to-treat and population per-protocol analysis will be performed. Discussion This is the first randomized study evaluating the impact of maternal lifestyle interventions during pregnancy on perinatal outcomes. The maternal lifestyle interventions (Mediterranean diet and mindfulness-based stress reduction program) are supported by scientific evidence, and their compliance will be evaluated with several biomarkers. Trial registration ClinicalTrials.gov NCT03166332. Registered on April 19, 2017

ACS Style

Francesca Crovetto; Fàtima Crispi; Roger Borras; Cristina Paules; Rosa Casas; Andrés Martín-Asuero; Angela Arranz; Eduard Vieta; Ramon Estruch; Eduard Gratacós. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. Trials 2021, 22, 1 -14.

AMA Style

Francesca Crovetto, Fàtima Crispi, Roger Borras, Cristina Paules, Rosa Casas, Andrés Martín-Asuero, Angela Arranz, Eduard Vieta, Ramon Estruch, Eduard Gratacós. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. Trials. 2021; 22 (1):1-14.

Chicago/Turabian Style

Francesca Crovetto; Fàtima Crispi; Roger Borras; Cristina Paules; Rosa Casas; Andrés Martín-Asuero; Angela Arranz; Eduard Vieta; Ramon Estruch; Eduard Gratacós. 2021. "Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial." Trials 22, no. 1: 1-14.

Dataset
Published: 22 May 2021
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ACS Style

Ramon Estruch; Rosa M. Casas. Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes. 2021, 1 .

AMA Style

Ramon Estruch, Rosa M. Casas. Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes. . 2021; ():1.

Chicago/Turabian Style

Ramon Estruch; Rosa M. Casas. 2021. "Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes." , no. : 1.

Journal article
Published: 12 May 2021 in Nutrients
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Accuracy of dietary assessment instruments such as food frequency questionnaire (FFQ) is crucial in the evaluation of diet–disease relationships. Test–retest reliability and concurrent and construct validity of a FFQ were evaluated in 150 pregnant women at high risk to develop fetal growth restriction randomly selected from those included in the improving mothers for better prenatal care trial Barcelona (IMPACT BCN). The FFQ and dietary records were performed at baseline and 34–36 weeks of gestation. Test–retest reliability of the FFQ for 12 food groups and 17 nutrients was moderate (ICC = 0.55) and good (ICC = 0.60), respectively. Concurrent validity between food, nutrients and a composite Mediterranean diet score (MedDiet score) and food records was fair for foods and nutrients (ρ average = 0.38 and 0.32, respectively) and moderate (r = 0.46) for the MedDiet score. Validation with biological markers ranged from poor (r = 0.07) for olives to moderate (r = 0.41) for nuts. A fair concordance between methods were found for nutrients (weighted κ = 0.22) and foods (weighted κ = 0.27). The FFQ-derived MedDiet score correlated in anticipated directions with intakes of nutrients and foods derived by food records. The FFQ showed a moderate test–retest reliability and reasonable validity to rank women according to their food and nutrient consumption and adherence to the Mediterranean diet.

ACS Style

Charlotte Juton; Sara Castro-Barquero; Rosa Casas; Tania Freitas; Ana Ruiz-León; Francesca Crovetto; Mónica Domenech; Fátima Crispi; Eduard Vieta; Eduard Gratacós; Ramon Estruch; Helmut Schroder. Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction. Nutrients 2021, 13, 1629 .

AMA Style

Charlotte Juton, Sara Castro-Barquero, Rosa Casas, Tania Freitas, Ana Ruiz-León, Francesca Crovetto, Mónica Domenech, Fátima Crispi, Eduard Vieta, Eduard Gratacós, Ramon Estruch, Helmut Schroder. Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction. Nutrients. 2021; 13 (5):1629.

Chicago/Turabian Style

Charlotte Juton; Sara Castro-Barquero; Rosa Casas; Tania Freitas; Ana Ruiz-León; Francesca Crovetto; Mónica Domenech; Fátima Crispi; Eduard Vieta; Eduard Gratacós; Ramon Estruch; Helmut Schroder. 2021. "Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction." Nutrients 13, no. 5: 1629.

Research article
Published: 27 April 2021 in European Eating Disorders Review
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Goals To explore affective and cognitive status, later in life, in individuals with and without previous history of eating disorder (ED), and also its association with higher risk for metabolic syndrome (MetS) symptomatology. Methods A cross‐sectional analysis of 6756 adults, aged 55–75 years with overweight/obesity and MetS participating in the Predimed‐Plus study was conducted. Participants completed self‐reported questionnaires to examine lifetime history of ED, according to DSM‐5 criteria, and other psychopathological and neurocognitive factors. Anthropometric and metabolic measurements were also collected. Results Of the whole sample, 24 individuals (0.35%) reported a previous history of ED. In this subsample, there were more women and singles compared to their counterparts, but they also presented higher levels of depressive symptoms and higher cognitive impairment, but also higher body mass index (BMI) and severe obesity, than those without lifetime ED. Conclusions This is one of the first studies to analyse the cognitive and metabolic impact of a previous history of ED. The results showed that previous ED was associated with greater affective and cognitive impairment, but also with higher BMI, later in life. No other MetS risk factors were found, after controlling for relevant variables.

ACS Style

Cristina Vintró‐Alcaraz; Isabel Baenas; María Lozano‐Madrid; Roser Granero; Miguel Ruiz‐Canela; Nancy Babio; Dolores Corella; Montserrat Fitó; José Alfredo Martínez; Ángel M. Alonso‐Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López‐Miranda; Ramon Estruch; María Rosa Bernal‐López; José Lapetra; Almudena Sánchez‐Villegas; Aurora Bueno‐Cavanillas; Josep A. Tur; Vicente Martin‐Sánchez; Xavier Pintó; Miguel Delgado‐Rodríguez; Pilar Matía‐Martín; Josep Vidal; Jersy J. Cárdenas; Lidia Daimiel; Emilio Ros; Cristina Razquin; Andrés Díaz‐López; José I. González; Laura Forcano; María De Los Ángeles Zulet; Maria C. Bello‐Mora; Silvia Valenzuela‐Guerrero; Manoli García de la Hera; Jadwiga Konieczna; Antonio García‐Ríos; Rosa Casas; Ana M. Gómez‐Pérez; Ana García‐Arellano; Mònica Bulló; José V. Sorli; Aida Cuenca‐Royo; Itziar Abete; Itziar Salaverria‐Lete; Francisco Javier Basterra‐Gortari; Rafael de la Torre; Jordi Salas‐Salvadó; Fernando Fernández‐Aranda. Psychological and metabolic risk factors in older adults with a previous history of eating disorder: A cross‐sectional study from the Predimed‐Plus study. European Eating Disorders Review 2021, 29, 575 -587.

AMA Style

Cristina Vintró‐Alcaraz, Isabel Baenas, María Lozano‐Madrid, Roser Granero, Miguel Ruiz‐Canela, Nancy Babio, Dolores Corella, Montserrat Fitó, José Alfredo Martínez, Ángel M. Alonso‐Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López‐Miranda, Ramon Estruch, María Rosa Bernal‐López, José Lapetra, Almudena Sánchez‐Villegas, Aurora Bueno‐Cavanillas, Josep A. Tur, Vicente Martin‐Sánchez, Xavier Pintó, Miguel Delgado‐Rodríguez, Pilar Matía‐Martín, Josep Vidal, Jersy J. Cárdenas, Lidia Daimiel, Emilio Ros, Cristina Razquin, Andrés Díaz‐López, José I. González, Laura Forcano, María De Los Ángeles Zulet, Maria C. Bello‐Mora, Silvia Valenzuela‐Guerrero, Manoli García de la Hera, Jadwiga Konieczna, Antonio García‐Ríos, Rosa Casas, Ana M. Gómez‐Pérez, Ana García‐Arellano, Mònica Bulló, José V. Sorli, Aida Cuenca‐Royo, Itziar Abete, Itziar Salaverria‐Lete, Francisco Javier Basterra‐Gortari, Rafael de la Torre, Jordi Salas‐Salvadó, Fernando Fernández‐Aranda. Psychological and metabolic risk factors in older adults with a previous history of eating disorder: A cross‐sectional study from the Predimed‐Plus study. European Eating Disorders Review. 2021; 29 (4):575-587.

Chicago/Turabian Style

Cristina Vintró‐Alcaraz; Isabel Baenas; María Lozano‐Madrid; Roser Granero; Miguel Ruiz‐Canela; Nancy Babio; Dolores Corella; Montserrat Fitó; José Alfredo Martínez; Ángel M. Alonso‐Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López‐Miranda; Ramon Estruch; María Rosa Bernal‐López; José Lapetra; Almudena Sánchez‐Villegas; Aurora Bueno‐Cavanillas; Josep A. Tur; Vicente Martin‐Sánchez; Xavier Pintó; Miguel Delgado‐Rodríguez; Pilar Matía‐Martín; Josep Vidal; Jersy J. Cárdenas; Lidia Daimiel; Emilio Ros; Cristina Razquin; Andrés Díaz‐López; José I. González; Laura Forcano; María De Los Ángeles Zulet; Maria C. Bello‐Mora; Silvia Valenzuela‐Guerrero; Manoli García de la Hera; Jadwiga Konieczna; Antonio García‐Ríos; Rosa Casas; Ana M. Gómez‐Pérez; Ana García‐Arellano; Mònica Bulló; José V. Sorli; Aida Cuenca‐Royo; Itziar Abete; Itziar Salaverria‐Lete; Francisco Javier Basterra‐Gortari; Rafael de la Torre; Jordi Salas‐Salvadó; Fernando Fernández‐Aranda. 2021. "Psychological and metabolic risk factors in older adults with a previous history of eating disorder: A cross‐sectional study from the Predimed‐Plus study." European Eating Disorders Review 29, no. 4: 575-587.

Journal article
Published: 22 April 2021 in Scientific Reports
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It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

ACS Style

Andrés Díaz-López; Indira Paz-Graniel; Verónica Ruiz; Estefanía Toledo; Nerea Becerra-Tomás; Dolores Corella; Olga Castañer; J. Alfredo Martínez; Ángel M. Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A. Tur; Vicente Martín Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Tania Fernandez Villa; Emilio Ros; Sonia Eguaras; Nancy Babio; Jose V. Sorlí; Albert Goday; Itziar Abete; Lucas Tojal Sierra; Francisco Javier Barón-López; Laura Torres-Collado; Marga Morey; Antonio Garcia-Rios; Rosa Casas; María Rosa Bernal-López; José Manuel Santos-Lozano; Adela Navarro; Jose I. Gonzalez; María Dolores Zomeño; Maria Angeles Zulet; Jessica Vaquero Luna; Raul Ramallal; Montse Fitó; Jordi Salas-Salvadó. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Scientific Reports 2021, 11, 1 -13.

AMA Style

Andrés Díaz-López, Indira Paz-Graniel, Verónica Ruiz, Estefanía Toledo, Nerea Becerra-Tomás, Dolores Corella, Olga Castañer, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín Sánchez, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Tania Fernandez Villa, Emilio Ros, Sonia Eguaras, Nancy Babio, Jose V. Sorlí, Albert Goday, Itziar Abete, Lucas Tojal Sierra, Francisco Javier Barón-López, Laura Torres-Collado, Marga Morey, Antonio Garcia-Rios, Rosa Casas, María Rosa Bernal-López, José Manuel Santos-Lozano, Adela Navarro, Jose I. Gonzalez, María Dolores Zomeño, Maria Angeles Zulet, Jessica Vaquero Luna, Raul Ramallal, Montse Fitó, Jordi Salas-Salvadó. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Scientific Reports. 2021; 11 (1):1-13.

Chicago/Turabian Style

Andrés Díaz-López; Indira Paz-Graniel; Verónica Ruiz; Estefanía Toledo; Nerea Becerra-Tomás; Dolores Corella; Olga Castañer; J. Alfredo Martínez; Ángel M. Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A. Tur; Vicente Martín Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Tania Fernandez Villa; Emilio Ros; Sonia Eguaras; Nancy Babio; Jose V. Sorlí; Albert Goday; Itziar Abete; Lucas Tojal Sierra; Francisco Javier Barón-López; Laura Torres-Collado; Marga Morey; Antonio Garcia-Rios; Rosa Casas; María Rosa Bernal-López; José Manuel Santos-Lozano; Adela Navarro; Jose I. Gonzalez; María Dolores Zomeño; Maria Angeles Zulet; Jessica Vaquero Luna; Raul Ramallal; Montse Fitó; Jordi Salas-Salvadó. 2021. "Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome." Scientific Reports 11, no. 1: 1-13.

Journal article
Published: 30 March 2021 in Nutrients
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Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile.

ACS Style

Roque Pastor-Ibáñez; Juan Blanco-Heredia; Florencia Etcheverry; Sonsoles Sánchez-Palomino; Francisco Díez-Fuertes; Rosa Casas; María Navarrete-Muñoz; Sara Castro-Barquero; Constanza Lucero; Irene Fernández; Lorna Leal; José Benito; Marc Noguera-Julian; Roger Paredes; Norma Rallón; Ramón Estruch; David Torrents; Felipe García. Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals. Nutrients 2021, 13, 1141 .

AMA Style

Roque Pastor-Ibáñez, Juan Blanco-Heredia, Florencia Etcheverry, Sonsoles Sánchez-Palomino, Francisco Díez-Fuertes, Rosa Casas, María Navarrete-Muñoz, Sara Castro-Barquero, Constanza Lucero, Irene Fernández, Lorna Leal, José Benito, Marc Noguera-Julian, Roger Paredes, Norma Rallón, Ramón Estruch, David Torrents, Felipe García. Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals. Nutrients. 2021; 13 (4):1141.

Chicago/Turabian Style

Roque Pastor-Ibáñez; Juan Blanco-Heredia; Florencia Etcheverry; Sonsoles Sánchez-Palomino; Francisco Díez-Fuertes; Rosa Casas; María Navarrete-Muñoz; Sara Castro-Barquero; Constanza Lucero; Irene Fernández; Lorna Leal; José Benito; Marc Noguera-Julian; Roger Paredes; Norma Rallón; Ramón Estruch; David Torrents; Felipe García. 2021. "Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals." Nutrients 13, no. 4: 1141.

Journal article
Published: 18 March 2021 in Clinical Nutrition
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Summary Background & aims The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. Methods PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. Results After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Conclusions Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.

ACS Style

Andrea J. Glenn; Pablo Hernández-Alonso; Cyril W.C. Kendall; Miguel Ángel Martínez-González; Dolores Corella; Montserrat Fitó; J.Alfredo Martínez; Ángel M. Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J. Tinahones; José Lapetra; J. Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A. Tur; Sofia Reguero Celada; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Sebastian Mas-Fontao; Lidia Daimiel; Emilio Ros; David J.A. Jenkins; Estefania Toledo; José V. Sorlí; Olga Castañer; Itziar Abete; Anai Moreno Rodriguez; Olga Fernández Barceló; Alejandro Oncina-Canovas; Jadwiga Konieczna; Antonio Garcia-Rios; Rosa Casas; Ana Maria Gómez-Pérez; José Manuel Santos-Lozano; Zenaida Vazquez-Ruiz; Olga Portolés; Helmut Schröder; Maria A. Zulet; Sonia Eguaras; Itziar Salaverria Lete; María Dolores Zomeño; John L. Sievenpiper; Jordi Salas-Salvadó. Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study. Clinical Nutrition 2021, 40, 2825 -2836.

AMA Style

Andrea J. Glenn, Pablo Hernández-Alonso, Cyril W.C. Kendall, Miguel Ángel Martínez-González, Dolores Corella, Montserrat Fitó, J.Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Sofia Reguero Celada, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Sebastian Mas-Fontao, Lidia Daimiel, Emilio Ros, David J.A. Jenkins, Estefania Toledo, José V. Sorlí, Olga Castañer, Itziar Abete, Anai Moreno Rodriguez, Olga Fernández Barceló, Alejandro Oncina-Canovas, Jadwiga Konieczna, Antonio Garcia-Rios, Rosa Casas, Ana Maria Gómez-Pérez, José Manuel Santos-Lozano, Zenaida Vazquez-Ruiz, Olga Portolés, Helmut Schröder, Maria A. Zulet, Sonia Eguaras, Itziar Salaverria Lete, María Dolores Zomeño, John L. Sievenpiper, Jordi Salas-Salvadó. Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study. Clinical Nutrition. 2021; 40 (5):2825-2836.

Chicago/Turabian Style

Andrea J. Glenn; Pablo Hernández-Alonso; Cyril W.C. Kendall; Miguel Ángel Martínez-González; Dolores Corella; Montserrat Fitó; J.Alfredo Martínez; Ángel M. Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J. Tinahones; José Lapetra; J. Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A. Tur; Sofia Reguero Celada; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Sebastian Mas-Fontao; Lidia Daimiel; Emilio Ros; David J.A. Jenkins; Estefania Toledo; José V. Sorlí; Olga Castañer; Itziar Abete; Anai Moreno Rodriguez; Olga Fernández Barceló; Alejandro Oncina-Canovas; Jadwiga Konieczna; Antonio Garcia-Rios; Rosa Casas; Ana Maria Gómez-Pérez; José Manuel Santos-Lozano; Zenaida Vazquez-Ruiz; Olga Portolés; Helmut Schröder; Maria A. Zulet; Sonia Eguaras; Itziar Salaverria Lete; María Dolores Zomeño; John L. Sievenpiper; Jordi Salas-Salvadó. 2021. "Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study." Clinical Nutrition 40, no. 5: 2825-2836.

Journal article
Published: 23 February 2021 in Clinical Nutrition
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Summary Background and aims Previous studies, mainly focused on quantity rather than variety, have shown beneficial associations between the amount of fruit and vegetable consumed, diet quality and healthy lifestyle. The aim is to evaluate the association between fruit and vegetable consumption, diet quality and lifestyle in an elderly Mediterranean population, considering both variety and the combination of quantity and variety (QV). Methods A cross-sectional analysis of 6647 participants (51.6% of males) was conducted in the framework of the PREDIMED-Plus study. A variety score was created as the sum of vegetables and/or fruits consumed at least once per month using food frequency questionnaires. Dietary Reference Intakes (EAR and IA values) were used to estimate the prevalence of inadequate intake of dietary fiber and micronutrients. Logistic regression models were performed to examine the association between fruit and vegetable consumption and not meeting the DRIs, by tertiles of fruit and vegetable variety and QV categories. Results Participants with higher fruit and vegetable variety score reported a significant higher intake of fiber, vitamins, minerals and flavonoids and were significantly more likely to be physically active and non-smoker. Besides, higher variety in fruit and vegetable consumption was associated with lower prevalence of having an inadequate intake of fiber [(0.13 (0.11–0.16)], two or more [(0.17 (0.14–0.21)], three or more [(0.15 (0.13–0.18)] and four or more [(0.11 (0.10–0.14)] micronutrients in our participants. Higher quantity and variety in fruit and vegetable consumption was associated with lower prevalence of having an inadequate intake of fiber [(0.05 (0.04–0.06)], two or more [(0.08 (0.06–0.10)], three or more [(0.08 (0.06–0.09)] and four or more [(0.06 (0.05–0.07)] micronutrients. Conclusion Greater variety in fruit and vegetable intake was associated with better nutrient adequacy, diet quality and healthier lifestyle in an elderly Mediterranean population.

ACS Style

Leyre López-González; Nerea Becerra-Tomás; Nancy Babio; Miguel Ángel Martínez-González; Andrés Díaz-López; Dolores Corella; Albert Goday; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramón Estruch; Francisco Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; José López-Miranda; Aurora Bueno-Cavanillas; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Lidia Daimiel; Laura Álvarez-Álvarez; Josep Vidal; Clotilde Vázquez; Emilio Ros; Zenaida Vázquez-Ruiz; Silvia Canudas; Rebeca Fernández Carrión; Olga Castañer; M.ángeles Zulet; Lucas Tojal Sierra; María Julia Ajejas Bazán; Carmen M. López García; Marian Martín; Antonio García-Ríos; Rosa Casas; Ana M. Gómez-Pérez; José Manuel Santos-Lozano; Estíbaliz Goñi; Patricia Guillem-Saiz; Camile Lassale; Itziar Abete; Itziar Salaverria Lete; Sonia Eguaras; Helmut Schröder; Jordi Salas-Salvadó. Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population. Clinical Nutrition 2021, 40, 1510 -1518.

AMA Style

Leyre López-González, Nerea Becerra-Tomás, Nancy Babio, Miguel Ángel Martínez-González, Andrés Díaz-López, Dolores Corella, Albert Goday, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Aurora Bueno-Cavanillas, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Laura Álvarez-Álvarez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Zenaida Vázquez-Ruiz, Silvia Canudas, Rebeca Fernández Carrión, Olga Castañer, M.ángeles Zulet, Lucas Tojal Sierra, María Julia Ajejas Bazán, Carmen M. López García, Marian Martín, Antonio García-Ríos, Rosa Casas, Ana M. Gómez-Pérez, José Manuel Santos-Lozano, Estíbaliz Goñi, Patricia Guillem-Saiz, Camile Lassale, Itziar Abete, Itziar Salaverria Lete, Sonia Eguaras, Helmut Schröder, Jordi Salas-Salvadó. Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population. Clinical Nutrition. 2021; 40 (4):1510-1518.

Chicago/Turabian Style

Leyre López-González; Nerea Becerra-Tomás; Nancy Babio; Miguel Ángel Martínez-González; Andrés Díaz-López; Dolores Corella; Albert Goday; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramón Estruch; Francisco Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; José López-Miranda; Aurora Bueno-Cavanillas; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Lidia Daimiel; Laura Álvarez-Álvarez; Josep Vidal; Clotilde Vázquez; Emilio Ros; Zenaida Vázquez-Ruiz; Silvia Canudas; Rebeca Fernández Carrión; Olga Castañer; M.ángeles Zulet; Lucas Tojal Sierra; María Julia Ajejas Bazán; Carmen M. López García; Marian Martín; Antonio García-Ríos; Rosa Casas; Ana M. Gómez-Pérez; José Manuel Santos-Lozano; Estíbaliz Goñi; Patricia Guillem-Saiz; Camile Lassale; Itziar Abete; Itziar Salaverria Lete; Sonia Eguaras; Helmut Schröder; Jordi Salas-Salvadó. 2021. "Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population." Clinical Nutrition 40, no. 4: 1510-1518.

Journal article
Published: 16 February 2021 in Nutrition, Metabolism and Cardiovascular Diseases
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Background and aims Total fruit consumption is important for cardiovascular disease prevention, but also the variety and form in which is consumed. The aim of the study was to assess the associations between total fruit, subgroups of fruits based on their color and fruit juices consumption with different cardiometabolic parameters. Methods and results A total of 6,633 elderly participants (aged 55-75 years) with metabolic syndrome from the PREDIMED-Plus study were included in this analysis. Fruit and fruit juice consumption was assessed using a food frequency questionnaire. Linear regression models were fitted to evaluate the association between exposure variables (total fruit, subgroups based on the color, and fruit juices) and different cardiometabolic risk factors. Individuals in the highest category of total fruit consumption (≥3 servings/d) had lower waist circumference (WC) (β=-1.04cm; 95%CI:-1.81, -0.26), fasting glucose levels (β=-2.41mg/dL; 95%CI(-4.19, -0.63) and LDL-cholesterol (β=-4.11mg/dL; 95%CI:-6.93, -1.36), but, unexpectedly, higher systolic blood pressure (BP) (β=1.84 mmHg; 95%CI: 0.37, 3.30) and diastolic BP (β=1.69 mmHg; 95%CI:0.83, 2.56) when compared to those in the lowest category of consumption (<1 servings/d). Participants consuming ≥1 serving/day of total fruit juice had lower WC (β=-0.92cm; 95%CI:-1.56, -0.27) and glucose levels (β=-1.59mg/dL; 95%CI:-2.95, -0.23) than those consuming <1serving/month. The associations with cardiometabolic risk factors differed according to the color of fruits. Conclusion Fruit consumption is associated with several cardiometabolic risk factors in Mediterranean elders with metabolic syndrome. The associations regarding BP levels could be attributed, at least partially, to reverse causality bias inherent to the cross-sectional design of the study.

ACS Style

Nerea Becerra-Tomás; Indira Paz-Graniel; Anna Tresserra-Rimbau; Miguel Ángel Martínez-González; Laura Barrubés; Dolores Corella; Júlia Muñoz-Martínez; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Maria R. Bernal-López; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio Garcia-Rios; Blanca Riquelme Gallego; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Lidia Daimiel; Sonsoles Velilla-Zancada; Josep Vidal; Clotilde Vázquez; Emilio Ros; Pilar Buil-Cosiales; Nancy Babio; Rebeca Fernández-Carrión; Karla Alejandra Pérez-Vega; Marga Morey; Laura Torres-Collado; Lucas Tojal-Sierra; Jessica Pérez-López; Itziar Abete; Judith Pérez Cabrera; Rosa Casas; José Carlos Fernandez-García; José Manuel Santos-Lozano; Virginia Esteve-Luque; Cristina Bouzas; Cesar I. Fernandez-Lazaro; José V. Sorlí; Gal·la Freixer; Marian Martín; Montserrat García Muñoz; Itziar Salaverria-Lete; Estefania Toledo; Olga Castañer; Jordi Salas-Salvadó. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis. Nutrition, Metabolism and Cardiovascular Diseases 2021, 31, 1702 -1713.

AMA Style

Nerea Becerra-Tomás, Indira Paz-Graniel, Anna Tresserra-Rimbau, Miguel Ángel Martínez-González, Laura Barrubés, Dolores Corella, Júlia Muñoz-Martínez, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Maria R. Bernal-López, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio Garcia-Rios, Blanca Riquelme Gallego, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Sonsoles Velilla-Zancada, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Nancy Babio, Rebeca Fernández-Carrión, Karla Alejandra Pérez-Vega, Marga Morey, Laura Torres-Collado, Lucas Tojal-Sierra, Jessica Pérez-López, Itziar Abete, Judith Pérez Cabrera, Rosa Casas, José Carlos Fernandez-García, José Manuel Santos-Lozano, Virginia Esteve-Luque, Cristina Bouzas, Cesar I. Fernandez-Lazaro, José V. Sorlí, Gal·la Freixer, Marian Martín, Montserrat García Muñoz, Itziar Salaverria-Lete, Estefania Toledo, Olga Castañer, Jordi Salas-Salvadó. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis. Nutrition, Metabolism and Cardiovascular Diseases. 2021; 31 (6):1702-1713.

Chicago/Turabian Style

Nerea Becerra-Tomás; Indira Paz-Graniel; Anna Tresserra-Rimbau; Miguel Ángel Martínez-González; Laura Barrubés; Dolores Corella; Júlia Muñoz-Martínez; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Maria R. Bernal-López; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio Garcia-Rios; Blanca Riquelme Gallego; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Lidia Daimiel; Sonsoles Velilla-Zancada; Josep Vidal; Clotilde Vázquez; Emilio Ros; Pilar Buil-Cosiales; Nancy Babio; Rebeca Fernández-Carrión; Karla Alejandra Pérez-Vega; Marga Morey; Laura Torres-Collado; Lucas Tojal-Sierra; Jessica Pérez-López; Itziar Abete; Judith Pérez Cabrera; Rosa Casas; José Carlos Fernandez-García; José Manuel Santos-Lozano; Virginia Esteve-Luque; Cristina Bouzas; Cesar I. Fernandez-Lazaro; José V. Sorlí; Gal·la Freixer; Marian Martín; Montserrat García Muñoz; Itziar Salaverria-Lete; Estefania Toledo; Olga Castañer; Jordi Salas-Salvadó. 2021. "Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis." Nutrition, Metabolism and Cardiovascular Diseases 31, no. 6: 1702-1713.

Journal article
Published: 27 January 2021 in Clinical Nutrition
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Summary Background & aims Ultra-processed food and drink products (UPF) consumption has been associated with obesity and its-related comorbidities. Excess of visceral fat, which appears with increasing age, has been considered as the culprit contributing to adiposity-associated adverse health outcomes. However, none of previous studies elucidated the link between UPF and directly quantified adiposity and its distribution. We aimed to prospectively investigate the association between concurrent changes in UPF consumption and objectively assessed adiposity distribution. Methods A subsample of 1485 PREDIMED-Plus participants (Spanish men and women aged 55–75 years with overweight/obesity and metabolic syndrome) underwent body composition measurements. Consumption of UPF at baseline, 6 and 12 months was evaluated using a validated 143-item semi-quantitative Food Frequency Questionnaire. Food items (g/day) were categorized according to their degree of processing using NOVA system. Regional adiposity (visceral fat (in g) and android-to-gynoid fat ratio) and total fat mass (in g) at three time points were measured with dual-energy X-ray absorptiometry (DXA) and were normalized using sex-specific z-scores. The association of changes in UPF consumption, expressed as the percentage of total daily intake (daily g of UPF/total daily g of food and beverage intake∗100), with adiposity changes was evaluated using linear mixed-effects models. Results On average, the consumption of UPF accounted for 8.11% (SD 7.41%) of total daily intake (in grams) at baseline. In multivariable-adjusted model, 10% daily increment in consumption of UPF was associated with significantly (all p-values <0.05) greater accumulation of visceral fat (β 0.09 z-scores, 95% CI 0.05; 0.13), android-to-gynoid fat ratio (0.05, 0.00; 0.09) and total fat (0.09, 0.06; 0.13). Conclusion A higher consumption of UPF was associated with greater age-related visceral and overall adiposity accumulation. Further studies are warranted to confirm these results in other populations and settings. Trial registration The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

ACS Style

Jadwiga Konieczna; Marga Morey; Itziar Abete; Maira Bes-Rastrollo; Miguel Ruiz-Canela; Jesus Vioque; Sandra Gonzalez-Palacios; Lidia Daimiel; Jordi Salas-Salvadó; Miguel Fiol; Vicente Martín; Ramón Estruch; Josep Vidal; Miguel A. Martínez-González; Silvia Canudas; Antoni J. Jover; Tania Fernández-Villa; Rosa Casas; Romina Olbeyra; Pilar Buil-Cosiales; Nancy Babio; Helmut Schröder; J. Alfredo Martínez; Dora Romaguera. Contribution of ultra-processed foods in visceral fat deposition and other adiposity indicators: Prospective analysis nested in the PREDIMED-Plus trial. Clinical Nutrition 2021, 40, 4290 -4300.

AMA Style

Jadwiga Konieczna, Marga Morey, Itziar Abete, Maira Bes-Rastrollo, Miguel Ruiz-Canela, Jesus Vioque, Sandra Gonzalez-Palacios, Lidia Daimiel, Jordi Salas-Salvadó, Miguel Fiol, Vicente Martín, Ramón Estruch, Josep Vidal, Miguel A. Martínez-González, Silvia Canudas, Antoni J. Jover, Tania Fernández-Villa, Rosa Casas, Romina Olbeyra, Pilar Buil-Cosiales, Nancy Babio, Helmut Schröder, J. Alfredo Martínez, Dora Romaguera. Contribution of ultra-processed foods in visceral fat deposition and other adiposity indicators: Prospective analysis nested in the PREDIMED-Plus trial. Clinical Nutrition. 2021; 40 (6):4290-4300.

Chicago/Turabian Style

Jadwiga Konieczna; Marga Morey; Itziar Abete; Maira Bes-Rastrollo; Miguel Ruiz-Canela; Jesus Vioque; Sandra Gonzalez-Palacios; Lidia Daimiel; Jordi Salas-Salvadó; Miguel Fiol; Vicente Martín; Ramón Estruch; Josep Vidal; Miguel A. Martínez-González; Silvia Canudas; Antoni J. Jover; Tania Fernández-Villa; Rosa Casas; Romina Olbeyra; Pilar Buil-Cosiales; Nancy Babio; Helmut Schröder; J. Alfredo Martínez; Dora Romaguera. 2021. "Contribution of ultra-processed foods in visceral fat deposition and other adiposity indicators: Prospective analysis nested in the PREDIMED-Plus trial." Clinical Nutrition 40, no. 6: 4290-4300.

Research article
Published: 06 January 2021 in BMC Medicine
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Background The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults. Methods Longitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55–75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants’ body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models. Results Increasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (β − 0.07% and − 0.08%) and visceral adipose tissue (VAT) (− 13.9 g, and − 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001). Conclusions At 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA. Trial registration International Standard Randomized Controlled Trial (ISRCTN), 89898870. Retrospectively registered on 24 July 2014

ACS Style

Aina M. Galmes-Panades; on behalf of the PREDIMED-Plus investigators; Jadwiga Konieczna; Veronica Varela-Mato; Itziar Abete; Nancy Babio; Miquel Fiol; José Antonio de Paz; Rosa Casas; Romina Olbeyra; Miguel Ruiz-Canela; Antoni Palau-Galindo; Olga Castañer; Arturo Martín-García; Ramón Estruch; Josep Vidal; Pilar Buil-Cosiales; Julia Wärnberg; Jordi Salas-Salvadó; J. Alfredo Martínez; Dora Romaguera. Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial. BMC Medicine 2021, 19, 1 -11.

AMA Style

Aina M. Galmes-Panades, on behalf of the PREDIMED-Plus investigators, Jadwiga Konieczna, Veronica Varela-Mato, Itziar Abete, Nancy Babio, Miquel Fiol, José Antonio de Paz, Rosa Casas, Romina Olbeyra, Miguel Ruiz-Canela, Antoni Palau-Galindo, Olga Castañer, Arturo Martín-García, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales, Julia Wärnberg, Jordi Salas-Salvadó, J. Alfredo Martínez, Dora Romaguera. Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial. BMC Medicine. 2021; 19 (1):1-11.

Chicago/Turabian Style

Aina M. Galmes-Panades; on behalf of the PREDIMED-Plus investigators; Jadwiga Konieczna; Veronica Varela-Mato; Itziar Abete; Nancy Babio; Miquel Fiol; José Antonio de Paz; Rosa Casas; Romina Olbeyra; Miguel Ruiz-Canela; Antoni Palau-Galindo; Olga Castañer; Arturo Martín-García; Ramón Estruch; Josep Vidal; Pilar Buil-Cosiales; Julia Wärnberg; Jordi Salas-Salvadó; J. Alfredo Martínez; Dora Romaguera. 2021. "Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial." BMC Medicine 19, no. 1: 1-11.

Correction
Published: 05 December 2020 in European Journal of Nutrition
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The original version of this article unfortunately contained a mistake. José M. Gámez was not listed among the authors.

ACS Style

Eva-Maria Navarrete-Muñoz; Jesus Vioque; Estefanía Toledo; Alejando Oncina-Canovas; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Dora Romaguera; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; José López-Miranda; Aurora Bueno-Cavanillas; Pilar Matía-Martín; Lidia Daimiel; Vicente Martín Sánchez; Josep Vidal; Ana Isabel De Cos Blanco; Emili Ros; Javier Diez-Espino; Nancy Babio; Rebeca Fernandez-Carrion; Olga Castañer; Antoni Colom; Laura Compañ-Gabucio; Itziar Salaverria Lete; Edelys Crespo-Oliva; Itziar Abete; Laura Tomaino; Rosa Casas; José Carlos Fernandez-Garcia; José Manuel Santos-Lozano; Iziar Sarasa; José M. Gámez; José M. Antonio Garcia-Rios; Sandra Martín-Pelaez; Miguel Ruiz-Canela; Andrés Díaz-López; Raul Martinez-Lacruz; Maria Dolors Zomeño; Elena Rayó; Cristina Gisbert Sellés; Silvia Canudas; Albert Goday; Manoli García-De-La-Hera. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study. European Journal of Nutrition 2020, 60, 1137 -1139.

AMA Style

Eva-Maria Navarrete-Muñoz, Jesus Vioque, Estefanía Toledo, Alejando Oncina-Canovas, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Montserrat Fitó, Dora Romaguera, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Aurora Bueno-Cavanillas, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín Sánchez, Josep Vidal, Ana Isabel De Cos Blanco, Emili Ros, Javier Diez-Espino, Nancy Babio, Rebeca Fernandez-Carrion, Olga Castañer, Antoni Colom, Laura Compañ-Gabucio, Itziar Salaverria Lete, Edelys Crespo-Oliva, Itziar Abete, Laura Tomaino, Rosa Casas, José Carlos Fernandez-Garcia, José Manuel Santos-Lozano, Iziar Sarasa, José M. Gámez, José M. Antonio Garcia-Rios, Sandra Martín-Pelaez, Miguel Ruiz-Canela, Andrés Díaz-López, Raul Martinez-Lacruz, Maria Dolors Zomeño, Elena Rayó, Cristina Gisbert Sellés, Silvia Canudas, Albert Goday, Manoli García-De-La-Hera. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study. European Journal of Nutrition. 2020; 60 (2):1137-1139.

Chicago/Turabian Style

Eva-Maria Navarrete-Muñoz; Jesus Vioque; Estefanía Toledo; Alejando Oncina-Canovas; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Dora Romaguera; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; José López-Miranda; Aurora Bueno-Cavanillas; Pilar Matía-Martín; Lidia Daimiel; Vicente Martín Sánchez; Josep Vidal; Ana Isabel De Cos Blanco; Emili Ros; Javier Diez-Espino; Nancy Babio; Rebeca Fernandez-Carrion; Olga Castañer; Antoni Colom; Laura Compañ-Gabucio; Itziar Salaverria Lete; Edelys Crespo-Oliva; Itziar Abete; Laura Tomaino; Rosa Casas; José Carlos Fernandez-Garcia; José Manuel Santos-Lozano; Iziar Sarasa; José M. Gámez; José M. Antonio Garcia-Rios; Sandra Martín-Pelaez; Miguel Ruiz-Canela; Andrés Díaz-López; Raul Martinez-Lacruz; Maria Dolors Zomeño; Elena Rayó; Cristina Gisbert Sellés; Silvia Canudas; Albert Goday; Manoli García-De-La-Hera. 2020. "Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study." European Journal of Nutrition 60, no. 2: 1137-1139.

Review
Published: 22 November 2020 in Nutrients
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Obesity in pregnancy has been directly associated with an increased risk of almost all pregnancy complications such as gestational hypertension, preeclampsia, gestational diabetes mellitus (GDM), and premature delivery. Thereby, according to current evidence available, life-style interventions to prevent pre-pregnancy overweight and obesity in women of fertile age are necessary to reduce the negative impact of obesity on mother and child health. Unhealthy dietary patterns, together with the increased consumption of processed foods rich in simple sugar and sweeteners are some of the responsible, among others, for the increase in obesity rates during the last years. Nevertheless, how its consumption can affect pregnancy outcomes and long-term children’s health is still uncertain. This review aims to collate the available evidence about the consequences of unhealthy dietary patterns and sugary products consumption, including sweeteners, during pregnancy for obesity in childhood and mid-childhood. High simple sugar intake during gestation may contribute to an excessive gestational weight gain (GWG) as well as to develop other pregnancy complications such as GDM, preeclampsia and preterm birth. The heterogeneity of study populations, sample size, different approaches to measure GWG, GMD, preeclampsia, and birth weight, among other conditions, might explain the divergences observed among studies. Therefore, large, well-designed intervention-controlled trials with biological biomarkers to ensure dietary adherence are necessary to evaluate the effectiveness of lifestyle interventions in order to provide effective nutritional advice.

ACS Style

Rosa Casas; Sara Castro Barquero; Ramon Estruch. Impact of Sugary Food Consumption on Pregnancy: A Review. Nutrients 2020, 12, 3574 .

AMA Style

Rosa Casas, Sara Castro Barquero, Ramon Estruch. Impact of Sugary Food Consumption on Pregnancy: A Review. Nutrients. 2020; 12 (11):3574.

Chicago/Turabian Style

Rosa Casas; Sara Castro Barquero; Ramon Estruch. 2020. "Impact of Sugary Food Consumption on Pregnancy: A Review." Nutrients 12, no. 11: 3574.

Journal article
Published: 02 November 2020 in Revista Española de Cardiología (English Edition)
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The ankle-brachial index (ABI) is an indicator of peripheral artery disease (PAD). The aim of this study was to assess the association between PAD, measured with the ABI, and cognitive function in persons with overweight or obesity and metabolic syndrome. Cross-sectional study conducted with baseline data from the PREDIMED-Plus study, which included 4898 participants (after exclusion of those without ABI measurements) aged between 55 and 75 years, and with overweight or obesity and metabolic syndrome. At the baseline assessment, we measured the ABI with a standardized protocol and assessed the presence of other cardiovascular risk factors (eg, diabetes, dyslipidemia, hypertension). Cognitive function was evaluated using several tests validated for the Spanish population (mini-mental state examination [MMSE], phonological and semantic verbal fluency test, WAIS-III working memory index [WMI], parts A and B of the trail making test (TMT), and clock drawing test). Generalized linear models were used to assess the association between the ABI and cognitive function. Among the participants, 3.4% had PAD defined as ABI ≤ 0.9, and 3.3% had arterial calcification defined as ABI ≥ 1.4. PAD was associated with age, systolic blood pressure and obesity indicators, while arterial calcification was also associated with obesity and diabetes. No significant associations were observed between cognitive function and ABI or PAD. In our sample, the presence of PAD increased with age, blood pressure, and obesity. No significant association was observed between ABI, PAD, or cognitive function. El índice tobillo-brazo (ITB) es un indicador de enfermedad arterial periférica (EAP). El objetivo de este estudio es evaluar la asociación entre la EAP medida con el ITB y el rendimiento cognitivo de individuos con sobrepeso u obesidad y síndrome metabólico. Estudio transversal realizado con los datos basales del estudio PREDIMED-Plus, en el que se incluyó a un total de 4.898 participantes (tras excluir a aquellos sin medición de ITB) de entre 55 y 75 años, con sobrepeso u obesidad y síndrome metabólico. En la visita basal se midió el ITB según un protocolo estandarizado, así como otros factores de riesgo cardiovascular (diabetes mellitus, dislipemia e hipertensión arterial, entre otros). Para la evaluación del rendimiento cognitivo, se aplicaron diferentes pruebas validadas en población española (Mini-mental Test, test de fluencia verbal semántica y fonológica, test de valoración de memoria de trabajo, test del trazo y test del reloj). Para evaluar la asociación entre el ITB y el rendimiento cognitivo, se utilizaron modelos lineales generalizados. El 3,4% de los participantes tenían EAP, definida por un ITB ≤ 0,9, y un 3,3%, calcificación arterial definida por un ITB ≥ 1,4. La EAP se asoció con la edad, la presión arterial sistólica y los indicadores de obesidad, mientras que la calcificación arterial se asoció también con obesidad y diabetes. Entre el rendimiento cognitivo y el ITB o la EAP, no se observaron asociaciones significativas. En nuestra muestra la EAP aumenta con la edad, la presión arterial y los indicadores de obesidad. No se observa una asociación significativa entre el ITB, la EAP y el rendimiento cognitivo.

ACS Style

Meritxell López; Angel Ríos; Dora Romaguera; Miguel Ángel Martínez-González; Fernando Fernández-Aranda; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Jesús Vioque; Ángel M. Alonso-Gómez; Edelys Crespo-Oliva; J. Alfredo Martínez; Luís Serra-Majem; Ramón Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio García-Ríos; Aurora Bueno-Cavanillas; José J. Gaforio; Pilar Matía-Martín; Lidia Daimiel; Rubén Sánchez-Rodríguez; Josep Vidal; Enrique Sanz-Martínez; Emilio Ros; Estefanía Toledo; Laura Barrubés; Rocío Barragán; Rafael De La Torre; Miquel Fiol; Sandra González-Palacios; Carolina Sorto-Sánchez; María Victoria Martín-Ruiz; María Ángeles Zulet; Fátima Díaz-Collado; Rosa Casas; José Carlos Fernández-García; José Manuel Santos-Lozano; Nuria Mallorqui-Bagué; Emma Argelich; Óscar Lecea; Indira Paz-Graniel; José V. Sorlí; Aida Cuenca; Susana Munuera; María Vicenta Hernándis-Marsán; Jessica Vaquero-Luna; Miguel Ruiz-Canela; Lucía Camacho-Barcia; Susana Jiménez-Murcia; Olga Castañer; Aina M. Yáñez. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment. Revista Española de Cardiología (English Edition) 2020, 1 .

AMA Style

Meritxell López, Angel Ríos, Dora Romaguera, Miguel Ángel Martínez-González, Fernando Fernández-Aranda, Jordi Salas-Salvadó, Dolores Corella, Montserrat Fitó, Jesús Vioque, Ángel M. Alonso-Gómez, Edelys Crespo-Oliva, J. Alfredo Martínez, Luís Serra-Majem, Ramón Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Aurora Bueno-Cavanillas, José J. Gaforio, Pilar Matía-Martín, Lidia Daimiel, Rubén Sánchez-Rodríguez, Josep Vidal, Enrique Sanz-Martínez, Emilio Ros, Estefanía Toledo, Laura Barrubés, Rocío Barragán, Rafael De La Torre, Miquel Fiol, Sandra González-Palacios, Carolina Sorto-Sánchez, María Victoria Martín-Ruiz, María Ángeles Zulet, Fátima Díaz-Collado, Rosa Casas, José Carlos Fernández-García, José Manuel Santos-Lozano, Nuria Mallorqui-Bagué, Emma Argelich, Óscar Lecea, Indira Paz-Graniel, José V. Sorlí, Aida Cuenca, Susana Munuera, María Vicenta Hernándis-Marsán, Jessica Vaquero-Luna, Miguel Ruiz-Canela, Lucía Camacho-Barcia, Susana Jiménez-Murcia, Olga Castañer, Aina M. Yáñez. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment. Revista Española de Cardiología (English Edition). 2020; ():1.

Chicago/Turabian Style

Meritxell López; Angel Ríos; Dora Romaguera; Miguel Ángel Martínez-González; Fernando Fernández-Aranda; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Jesús Vioque; Ángel M. Alonso-Gómez; Edelys Crespo-Oliva; J. Alfredo Martínez; Luís Serra-Majem; Ramón Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio García-Ríos; Aurora Bueno-Cavanillas; José J. Gaforio; Pilar Matía-Martín; Lidia Daimiel; Rubén Sánchez-Rodríguez; Josep Vidal; Enrique Sanz-Martínez; Emilio Ros; Estefanía Toledo; Laura Barrubés; Rocío Barragán; Rafael De La Torre; Miquel Fiol; Sandra González-Palacios; Carolina Sorto-Sánchez; María Victoria Martín-Ruiz; María Ángeles Zulet; Fátima Díaz-Collado; Rosa Casas; José Carlos Fernández-García; José Manuel Santos-Lozano; Nuria Mallorqui-Bagué; Emma Argelich; Óscar Lecea; Indira Paz-Graniel; José V. Sorlí; Aida Cuenca; Susana Munuera; María Vicenta Hernándis-Marsán; Jessica Vaquero-Luna; Miguel Ruiz-Canela; Lucía Camacho-Barcia; Susana Jiménez-Murcia; Olga Castañer; Aina M. Yáñez. 2020. "Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment." Revista Española de Cardiología (English Edition) , no. : 1.

Original contribution
Published: 30 October 2020 in European Journal of Nutrition
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Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 ± 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44–0.90 and OR 0.56; 95% CI 0.38–0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47–0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS. ISRCTN89898870. Registration date: July 24, 2014.

ACS Style

Indira Paz-Graniel; the PREDIMED-Plus Investigators; Nancy Babio; Nerea Becerra-Tomás; Estefania Toledo; Lucia Camacho-Barcia; Dolores Corella; Olga Castañer-Niño; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; Fernando Fernandez-Aranda; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio García-Rios; Aurora Bueno-Cavanillas; José J. Gaforio; Pilar Matía-Martín; Lidia Daimiel; Vicente Martín Sánchez; Josep Vidal; Lucía Prieto-Sanchez; Emilio Ros; Cristina Razquin; Cristina Mestres; José V. Sorli; Aida M. Cuenca-Royo; Angel Rios; Laura Torres-Collado; Jessica Vaquero-Luna; Napoleon Pérez-Farinós; M. Angeles Zulet; Almudena Sanchez-Villegas; Rosa Casas; M Rosa Bernal-Lopez; José Manuel Santos-Lozano; Xavier Corbella; David Mateos; Pilar Buil-Cosiales; Susana Jiménez-Murcia; Rebeca Fernandez-Carrion; Laura Forcano-Gamazo; Miguel Ángel Sempere-Pascual; Anai Moreno-Rodriguez; Alfredo Gea; Rafael De La Torre-Fornell; Jordi Salas-Salvadó. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population. European Journal of Nutrition 2020, 1 -16.

AMA Style

Indira Paz-Graniel, the PREDIMED-Plus Investigators, Nancy Babio, Nerea Becerra-Tomás, Estefania Toledo, Lucia Camacho-Barcia, Dolores Corella, Olga Castañer-Niño, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, Fernando Fernandez-Aranda, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Rios, Aurora Bueno-Cavanillas, José J. Gaforio, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín Sánchez, Josep Vidal, Lucía Prieto-Sanchez, Emilio Ros, Cristina Razquin, Cristina Mestres, José V. Sorli, Aida M. Cuenca-Royo, Angel Rios, Laura Torres-Collado, Jessica Vaquero-Luna, Napoleon Pérez-Farinós, M. Angeles Zulet, Almudena Sanchez-Villegas, Rosa Casas, M Rosa Bernal-Lopez, José Manuel Santos-Lozano, Xavier Corbella, David Mateos, Pilar Buil-Cosiales, Susana Jiménez-Murcia, Rebeca Fernandez-Carrion, Laura Forcano-Gamazo, Miguel Ángel Sempere-Pascual, Anai Moreno-Rodriguez, Alfredo Gea, Rafael De La Torre-Fornell, Jordi Salas-Salvadó. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population. European Journal of Nutrition. 2020; ():1-16.

Chicago/Turabian Style

Indira Paz-Graniel; the PREDIMED-Plus Investigators; Nancy Babio; Nerea Becerra-Tomás; Estefania Toledo; Lucia Camacho-Barcia; Dolores Corella; Olga Castañer-Niño; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; Fernando Fernandez-Aranda; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio García-Rios; Aurora Bueno-Cavanillas; José J. Gaforio; Pilar Matía-Martín; Lidia Daimiel; Vicente Martín Sánchez; Josep Vidal; Lucía Prieto-Sanchez; Emilio Ros; Cristina Razquin; Cristina Mestres; José V. Sorli; Aida M. Cuenca-Royo; Angel Rios; Laura Torres-Collado; Jessica Vaquero-Luna; Napoleon Pérez-Farinós; M. Angeles Zulet; Almudena Sanchez-Villegas; Rosa Casas; M Rosa Bernal-Lopez; José Manuel Santos-Lozano; Xavier Corbella; David Mateos; Pilar Buil-Cosiales; Susana Jiménez-Murcia; Rebeca Fernandez-Carrion; Laura Forcano-Gamazo; Miguel Ángel Sempere-Pascual; Anai Moreno-Rodriguez; Alfredo Gea; Rafael De La Torre-Fornell; Jordi Salas-Salvadó. 2020. "Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population." European Journal of Nutrition , no. : 1-16.

Review
Published: 30 October 2020 in Molecules
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Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs). In the aim to find a possible preventive and intervention strategy, the Mediterranean diet (MedDiet) has been proposed as an effective approach. Within the MedDiet, moderate wine consumption with meals is a positive item in the MedDiet score; however, recent studies have reported a dose-response association between alcohol consumption and higher risk of a large number of NCDs. This review aimed to evaluate the association between NCDs and wine consumption in the framework of the MedDiet, with a simple review of 22 studies of the highest-level literature published over the last five years. We found that the information regarding the effects of wine in different health outcomes has not varied widely over the past five years, finding inconclusive results among the studies evaluated. Most of the literature agrees that light to moderate wine intake seems to have beneficial effects to some extent in NCDs, such as hypertension, cancer, dyslipidemia and dementia, but no definitive recommendations can be made on a specific dose intake that can benefit most diseases.

ACS Style

Simona Minzer; Ramon Estruch; Rosa Casas. Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years. Molecules 2020, 25, 5045 .

AMA Style

Simona Minzer, Ramon Estruch, Rosa Casas. Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years. Molecules. 2020; 25 (21):5045.

Chicago/Turabian Style

Simona Minzer; Ramon Estruch; Rosa Casas. 2020. "Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years." Molecules 25, no. 21: 5045.

Journal article
Published: 09 October 2020 in Atherosclerosis
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Background and aimsThe aim of this study was to ascertain the association between the consumption of different categories of edible olive oils (virgin olive oils and olive oil) and olive pomace oil and ankle-brachial pressure index (ABI) in participants in the PREDIMED-Plus study, a trial of lifestyle modification for weight and cardiovascular event reduction in individuals with overweight/obesity harboring the metabolic syndrome.MethodsWe performed a cross-sectional analysis of the PREDIMED-Plus trial. Consumption of any category of olive oil and olive pomace oil was assessed through a validated food-frequency questionnaire. Multivariable linear regression models were fitted to assess associations between olive oil consumption and ABI. Additionally, ABI ≤1 was considered as the outcome in logistic models with different categories of olive oil and olive pomace oil as exposure.ResultsAmong 4330 participants, the highest quintile of total olive oil consumption (sum of all categories of olive oil and olive pomace oil) was associated with higher mean values of ABI (beta coefficient: 0.014, 95% confidence interval [CI]: 0.002, 0.027) (p for trend = 0.010). Logistic models comparing the consumption of different categories of olive oils, olive pomace oil and ABI ≤1 values revealed an inverse association between virgin olive oils consumption and the likelihood of a low ABI (odds ratio [OR] 0.73, 95% CI [0.56, 0.97]), while consumption of olive pomace oil was positively associated with a low ABI (OR 1.22 95% CI [1.00, 1.48]).ConclusionsIn a Mediterranean population at high cardiovascular risk, total olive oil consumption was associated with a higher mean ABI. These results suggest that olive oil consumption may be beneficial for peripheral artery disease prevention, but longitudinal studies are needed.

ACS Style

Cristina Sánchez-Quesada; Estefanía Toledo; Guadalupe González-Mata; Maria Isabel Ramos-Ballesta; José Ignacio Peis; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio Garcia-Rios; Naomi Cano-Ibáñez; Pilar Matía-Martín; Lidia Daimiel; Rubén Sánchez-Rodríguez; Josep Vidal; Clotilde Vázquez; Emilio Ros; Pablo Hernández-Alonso; Rocío Barragan; Julia Muñoz-Martínez; Meritxell López; Sandra González-Palacios; Jessica Vaquero-Luna; Edelys Crespo-Oliva; M. Angeles Zulet; Vanessa Díaz-González; Rosa Casas; José Carlos Fernandez-Garcia; José Manuel Santos-Lozano; Ana Galera; Tomás Ripoll-Vera; Pilar Buil-Cosiales; Silvia Canudas; Raul Martinez-Lacruz; Karla-Alejandra Pérez-Vega; Ángel Rios; Rosario Lloret-Macián; Anai Moreno-Rodriguez; Miguel Ruiz-Canela; Nancy Babio; Maria Dolores Zomeño Fajardo; José J. Gaforio. Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk. Atherosclerosis 2020, 314, 48 -57.

AMA Style

Cristina Sánchez-Quesada, Estefanía Toledo, Guadalupe González-Mata, Maria Isabel Ramos-Ballesta, José Ignacio Peis, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Montserrat Fitó, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio Garcia-Rios, Naomi Cano-Ibáñez, Pilar Matía-Martín, Lidia Daimiel, Rubén Sánchez-Rodríguez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pablo Hernández-Alonso, Rocío Barragan, Julia Muñoz-Martínez, Meritxell López, Sandra González-Palacios, Jessica Vaquero-Luna, Edelys Crespo-Oliva, M. Angeles Zulet, Vanessa Díaz-González, Rosa Casas, José Carlos Fernandez-Garcia, José Manuel Santos-Lozano, Ana Galera, Tomás Ripoll-Vera, Pilar Buil-Cosiales, Silvia Canudas, Raul Martinez-Lacruz, Karla-Alejandra Pérez-Vega, Ángel Rios, Rosario Lloret-Macián, Anai Moreno-Rodriguez, Miguel Ruiz-Canela, Nancy Babio, Maria Dolores Zomeño Fajardo, José J. Gaforio. Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk. Atherosclerosis. 2020; 314 ():48-57.

Chicago/Turabian Style

Cristina Sánchez-Quesada; Estefanía Toledo; Guadalupe González-Mata; Maria Isabel Ramos-Ballesta; José Ignacio Peis; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Dora Romaguera; Jesús Vioque; Ángel M. Alonso-Gómez; Julia Wärnberg; J. Alfredo Martínez; Luís Serra-Majem; Ramon Estruch; Francisco J. Tinahones; José Lapetra; Xavier Pintó; Josep A. Tur; Antonio Garcia-Rios; Naomi Cano-Ibáñez; Pilar Matía-Martín; Lidia Daimiel; Rubén Sánchez-Rodríguez; Josep Vidal; Clotilde Vázquez; Emilio Ros; Pablo Hernández-Alonso; Rocío Barragan; Julia Muñoz-Martínez; Meritxell López; Sandra González-Palacios; Jessica Vaquero-Luna; Edelys Crespo-Oliva; M. Angeles Zulet; Vanessa Díaz-González; Rosa Casas; José Carlos Fernandez-Garcia; José Manuel Santos-Lozano; Ana Galera; Tomás Ripoll-Vera; Pilar Buil-Cosiales; Silvia Canudas; Raul Martinez-Lacruz; Karla-Alejandra Pérez-Vega; Ángel Rios; Rosario Lloret-Macián; Anai Moreno-Rodriguez; Miguel Ruiz-Canela; Nancy Babio; Maria Dolores Zomeño Fajardo; José J. Gaforio. 2020. "Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk." Atherosclerosis 314, no. : 48-57.

Journal article
Published: 30 September 2020 in Molecular Nutrition & Food Research
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ACS Style

Álvaro Hernáez; Olga Castañer; Anna Tresserra‐Rimbau; Xavier Pintó; Montserrat Fitó; Rosa Casas; Miguel Ángel Martínez‐González; Dolores Corella; Jordi Salas-Salvadó; José Lapetra; Enrique Gómez‐Gracia; Fernando Arós; Miquel Fiol; Lluis Serra‐Majem; Emilio Ros; Ramón Estruch. Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research 2020, 64, 1 .

AMA Style

Álvaro Hernáez, Olga Castañer, Anna Tresserra‐Rimbau, Xavier Pintó, Montserrat Fitó, Rosa Casas, Miguel Ángel Martínez‐González, Dolores Corella, Jordi Salas-Salvadó, José Lapetra, Enrique Gómez‐Gracia, Fernando Arós, Miquel Fiol, Lluis Serra‐Majem, Emilio Ros, Ramón Estruch. Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research. 2020; 64 (20):1.

Chicago/Turabian Style

Álvaro Hernáez; Olga Castañer; Anna Tresserra‐Rimbau; Xavier Pintó; Montserrat Fitó; Rosa Casas; Miguel Ángel Martínez‐González; Dolores Corella; Jordi Salas-Salvadó; José Lapetra; Enrique Gómez‐Gracia; Fernando Arós; Miquel Fiol; Lluis Serra‐Majem; Emilio Ros; Ramón Estruch. 2020. "Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial." Molecular Nutrition & Food Research 64, no. 20: 1.

Review
Published: 29 September 2020 in Nutrients
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Metabolic syndrome is a cluster of metabolic risk factors, characterized by abdominal obesity, dyslipidemia, low levels of high-density lipoprotein cholesterol (HDL-c), hypertension, and insulin resistance. Lifestyle modifications, especially dietary habits, are the main therapeutic strategy for the treatment and management of metabolic syndrome, but the most effective dietary pattern for its management has not been established. Specific dietary modifications, such as improving the quality of the foods or changing macronutrient distribution, showed beneficial effects on metabolic syndrome conditions and individual parameters. On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment. The nutritional distribution and quality of these healthy diets allows health professionals to provide easy-to-follow dietary advice without the need for restricted diets. Nonetheless, energy-restricted dietary patterns and improvements in physical activity are crucial to improve the metabolic disturbances observed in metabolic syndrome patients.

ACS Style

Sara Castro-Barquero; Ana María Ruiz-León; Maria Sierra-Pérez; Ramon Estruch; Rosa Casas. Dietary Strategies for Metabolic Syndrome: A Comprehensive Review. Nutrients 2020, 12, 2983 .

AMA Style

Sara Castro-Barquero, Ana María Ruiz-León, Maria Sierra-Pérez, Ramon Estruch, Rosa Casas. Dietary Strategies for Metabolic Syndrome: A Comprehensive Review. Nutrients. 2020; 12 (10):2983.

Chicago/Turabian Style

Sara Castro-Barquero; Ana María Ruiz-León; Maria Sierra-Pérez; Ramon Estruch; Rosa Casas. 2020. "Dietary Strategies for Metabolic Syndrome: A Comprehensive Review." Nutrients 12, no. 10: 2983.