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Dr. Ramon Estruch
Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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0 Atherosclerosis
0 Beer
0 Cardiovascular Disease
0 Inflammation

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Mediterranean diet
Cardiovascular Disease
Obesity
Alcohol
Wine
cardiovascular risk factors
Atherosclerosis
Inflammation
Beer
Oxidative Stress
diabetes mellitus
Lipids

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Short communication
Published: 28 August 2021 in Revista Española de Cardiología
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ACS Style

Ramón Estruch; Emilio Sacanella. ¿Mejor una imagen que mil palabras también en la valoración del riesgo vascular? Revista Española de Cardiología 2021, 1 .

AMA Style

Ramón Estruch, Emilio Sacanella. ¿Mejor una imagen que mil palabras también en la valoración del riesgo vascular? Revista Española de Cardiología. 2021; ():1.

Chicago/Turabian Style

Ramón Estruch; Emilio Sacanella. 2021. "¿Mejor una imagen que mil palabras también en la valoración del riesgo vascular?" Revista Española de Cardiología , no. : 1.

Journal article
Published: 22 August 2021 in Nutrients
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Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60–80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (−3.13 μg/mg (−5.54, −0.71), p-value = 0.016 and −3.03 μg/mg (−5.62, −0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.

ACS Style

Inés Domínguez-López; Isabella Parilli-Moser; Camila Arancibia-Riveros; Anna Tresserra-Rimbau; Miguel Angel Martínez-González; Carolina Ortega-Azorín; Jordi Salas-Salvadó; Olga Castañer; José Lapetra; Fernando Arós; Miquel Fiol; Lluis Serra-Majem; Xavier Pintó; Enrique Gómez-Gracia; Emilio Ros; Rosa M. Lamuela-Raventós; Ramon Estruch. Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol. Nutrients 2021, 13, 2883 .

AMA Style

Inés Domínguez-López, Isabella Parilli-Moser, Camila Arancibia-Riveros, Anna Tresserra-Rimbau, Miguel Angel Martínez-González, Carolina Ortega-Azorín, Jordi Salas-Salvadó, Olga Castañer, José Lapetra, Fernando Arós, Miquel Fiol, Lluis Serra-Majem, Xavier Pintó, Enrique Gómez-Gracia, Emilio Ros, Rosa M. Lamuela-Raventós, Ramon Estruch. Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol. Nutrients. 2021; 13 (8):2883.

Chicago/Turabian Style

Inés Domínguez-López; Isabella Parilli-Moser; Camila Arancibia-Riveros; Anna Tresserra-Rimbau; Miguel Angel Martínez-González; Carolina Ortega-Azorín; Jordi Salas-Salvadó; Olga Castañer; José Lapetra; Fernando Arós; Miquel Fiol; Lluis Serra-Majem; Xavier Pintó; Enrique Gómez-Gracia; Emilio Ros; Rosa M. Lamuela-Raventós; Ramon Estruch. 2021. "Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol." Nutrients 13, no. 8: 2883.

Original article
Published: 09 August 2021 in Clinical Nutrition
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Summary Objective To examine associations between intake of simple sugars and cancer incidence, cancer mortality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 ± 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03–1.13) for total liquid sugar, 1.19 (95% CI, 1.07–1.31) for liquid glucose, 1.14 (95% CI, 1.05–1.23) for liquid fructose, and 1.39 (95% CI, 1.10–1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality.

ACS Style

Juan C. Laguna; Marta Alegret; Montserrat Cofán; Ana Sánchez-Tainta; Andrés Díaz-López; Miguel A. Martínez-González; José V. Sorlí; Jordi Salas-Salvadó; Montserrat Fitó; Ángel M. Alonso-Gómez; Lluís Serra-Majem; José Lapetra; Miquel Fiol; Enrique Gómez-Gracia; Xavier Pintó; Miguel A. Muñoz; Olga Castañer; Judith B. Ramírez-Sabio; José J. Portu; Ramón Estruch; Emilio Ros. Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial. Clinical Nutrition 2021, 1 .

AMA Style

Juan C. Laguna, Marta Alegret, Montserrat Cofán, Ana Sánchez-Tainta, Andrés Díaz-López, Miguel A. Martínez-González, José V. Sorlí, Jordi Salas-Salvadó, Montserrat Fitó, Ángel M. Alonso-Gómez, Lluís Serra-Majem, José Lapetra, Miquel Fiol, Enrique Gómez-Gracia, Xavier Pintó, Miguel A. Muñoz, Olga Castañer, Judith B. Ramírez-Sabio, José J. Portu, Ramón Estruch, Emilio Ros. Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial. Clinical Nutrition. 2021; ():1.

Chicago/Turabian Style

Juan C. Laguna; Marta Alegret; Montserrat Cofán; Ana Sánchez-Tainta; Andrés Díaz-López; Miguel A. Martínez-González; José V. Sorlí; Jordi Salas-Salvadó; Montserrat Fitó; Ángel M. Alonso-Gómez; Lluís Serra-Majem; José Lapetra; Miquel Fiol; Enrique Gómez-Gracia; Xavier Pintó; Miguel A. Muñoz; Olga Castañer; Judith B. Ramírez-Sabio; José J. Portu; Ramón Estruch; Emilio Ros. 2021. "Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial." Clinical Nutrition , no. : 1.

Journal article
Published: 22 July 2021 in Biomedicines
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The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p< 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p< 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.

ACS Style

Mireia Urpi-Sarda; Rosa Casas; Emilio Sacanella; Dolores Corella; Cristina Andrés-Lacueva; Rafael Llorach; Gloria Garrabou; Francesc Cardellach; Aleix Sala-Vila; Emilio Ros; Miguel Ruiz-Canela; Montserrat Fitó; Jordi Salas-Salvadó; Ramon Estruch. The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines 2021, 9, 862 .

AMA Style

Mireia Urpi-Sarda, Rosa Casas, Emilio Sacanella, Dolores Corella, Cristina Andrés-Lacueva, Rafael Llorach, Gloria Garrabou, Francesc Cardellach, Aleix Sala-Vila, Emilio Ros, Miguel Ruiz-Canela, Montserrat Fitó, Jordi Salas-Salvadó, Ramon Estruch. The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines. 2021; 9 (8):862.

Chicago/Turabian Style

Mireia Urpi-Sarda; Rosa Casas; Emilio Sacanella; Dolores Corella; Cristina Andrés-Lacueva; Rafael Llorach; Gloria Garrabou; Francesc Cardellach; Aleix Sala-Vila; Emilio Ros; Miguel Ruiz-Canela; Montserrat Fitó; Jordi Salas-Salvadó; Ramon Estruch. 2021. "The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease." Biomedicines 9, no. 8: 862.

Journal article
Published: 20 July 2021 in Nutrients
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The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different food processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether the association between UPF consumption and cardiometabolic markers changes with the classification system, we used baseline data from 5636 participants (48.5% female and 51.5% male, mean age 65.1 ± 4.9) of the PREDIMED-Plus (“PREvention with MEDiterranean DIet”) trial. Subjects presented with overweight or obesity and met at least three metabolic syndrome (MetS) criteria. Food consumption was classified using a 143-item food frequency questionnaire according to four food processing-based classifications: NOVA, International Agency for Research on Cancer (IARC), International Food Information Council (IFIC) and University of North Carolina (UNC). Mean changes in nutritional and cardiometabolic markers were assessed according to quintiles of UPF consumption for each system. The association between UPF consumption and cardiometabolic markers was assessed using linear regression analysis. The concordance of the different classifications was assessed with intra-class correlation coefficients (ICC3, overall = 0.51). The highest UPF consumption was obtained with the IARC classification (45.9%) and the lowest with NOVA (7.9%). Subjects with high UPF consumption showed a poor dietary profile. We detected a direct association between UPF consumption and BMI (p = 0.001) when using the NOVA system, and with systolic (p = 0.018) and diastolic (p = 0.042) blood pressure when using the UNC system. Food classification methodologies markedly influenced the association between UPF consumption and cardiometabolic risk markers.

ACS Style

Celia Martinez-Perez; Rodrigo San-Cristobal; Pilar Guallar-Castillon; Miguel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Olga Castañer; Jose Martinez; Ángel Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco Tinahones; José Lapetra; Lluis Serra-Majem; Aurora Bueno-Cavanillas; Josep Tur; Vicente Sánchez; Xavier Pintó; José Gaforio; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Emilio Ros; Maira Bes-Rastrollo; Nancy Babio; Jose Sorlí; Camille Lassale; Beatriz Pérez-Sanz; Jessica Vaquero-Luna; María Bazán; María Barceló-Iglesias; Jadwiga Konieczna; Antonio Ríos; María Bernal-López; José Santos-Lozano; Estefanía Toledo; Nerea Becerra-Tomás; Olga Portoles; María Zomeño; Itziar Abete; Anai Moreno-Rodriguez; Oscar Lecea-Juarez; Stephanie Nishi; Júlia Muñoz-Martínez; José Ordovás; Lidia Daimiel. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort). Nutrients 2021, 13, 2471 .

AMA Style

Celia Martinez-Perez, Rodrigo San-Cristobal, Pilar Guallar-Castillon, Miguel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Olga Castañer, Jose Martinez, Ángel Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco Tinahones, José Lapetra, Lluis Serra-Majem, Aurora Bueno-Cavanillas, Josep Tur, Vicente Sánchez, Xavier Pintó, José Gaforio, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Maira Bes-Rastrollo, Nancy Babio, Jose Sorlí, Camille Lassale, Beatriz Pérez-Sanz, Jessica Vaquero-Luna, María Bazán, María Barceló-Iglesias, Jadwiga Konieczna, Antonio Ríos, María Bernal-López, José Santos-Lozano, Estefanía Toledo, Nerea Becerra-Tomás, Olga Portoles, María Zomeño, Itziar Abete, Anai Moreno-Rodriguez, Oscar Lecea-Juarez, Stephanie Nishi, Júlia Muñoz-Martínez, José Ordovás, Lidia Daimiel. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort). Nutrients. 2021; 13 (7):2471.

Chicago/Turabian Style

Celia Martinez-Perez; Rodrigo San-Cristobal; Pilar Guallar-Castillon; Miguel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Olga Castañer; Jose Martinez; Ángel Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco Tinahones; José Lapetra; Lluis Serra-Majem; Aurora Bueno-Cavanillas; Josep Tur; Vicente Sánchez; Xavier Pintó; José Gaforio; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Emilio Ros; Maira Bes-Rastrollo; Nancy Babio; Jose Sorlí; Camille Lassale; Beatriz Pérez-Sanz; Jessica Vaquero-Luna; María Bazán; María Barceló-Iglesias; Jadwiga Konieczna; Antonio Ríos; María Bernal-López; José Santos-Lozano; Estefanía Toledo; Nerea Becerra-Tomás; Olga Portoles; María Zomeño; Itziar Abete; Anai Moreno-Rodriguez; Oscar Lecea-Juarez; Stephanie Nishi; Júlia Muñoz-Martínez; José Ordovás; Lidia Daimiel. 2021. "Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort)." Nutrients 13, no. 7: 2471.

Short communication
Published: 06 July 2021 in Revista Española de Cardiología (English Edition)
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ACS Style

Ramón Estruch; Emilio Sacanella. Is a picture worth a thousand words in cardiovascular risk assessment? Revista Española de Cardiología (English Edition) 2021, 1 .

AMA Style

Ramón Estruch, Emilio Sacanella. Is a picture worth a thousand words in cardiovascular risk assessment? Revista Española de Cardiología (English Edition). 2021; ():1.

Chicago/Turabian Style

Ramón Estruch; Emilio Sacanella. 2021. "Is a picture worth a thousand words in cardiovascular risk assessment?" Revista Española de Cardiología (English Edition) , no. : 1.

Journal article
Published: 05 July 2021 in International Journal of Food Sciences and Nutrition
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The traditional Mediterranean diet is considered the world’s most evidence-based eating pattern for promoting health and longevity. However, institutional food environments and their busy consumers often sacrifice health benefits for the convenience of faster and cheaper foods that generally are of lower quality and are more processed, and thus, contribute to the current epidemics of obesity and diabetes. Expert consensus has even identified the Mediterranean diet as the easiest to follow among healthy eating patterns. Nonetheless, fewer American families cook at home and many food services have been slow to implement healthier food options compatible with the Mediterranean diet. In September 2019, we convened a group of thought leaders at an exploratory seminar entitled: “Mediterranean Diet: Promotion and Dissemination of Healthy Eating”, hosted by the Radcliffe Institute for Advanced Studies at Harvard University. The multidisciplinary faculty discussed best practices for translating traditional Mediterranean lifestyle principles to modern society.

ACS Style

Mercedes Sotos-Prieto; Daniele Del Rio; Greg Drescher; Ramon Estruch; Chavanne Hanson; Timothy Harlan; Frank B. Hu; Maria Loi; James P. McClung; Angelo Mojica; Daniela Puglielli; Ken Toong; Fania Yangarber; Stefanos N. Kales. Mediterranean diet – promotion and dissemination of healthy eating: proceedings of an exploratory seminar at the Radcliffe institute for advanced study. International Journal of Food Sciences and Nutrition 2021, 1 -14.

AMA Style

Mercedes Sotos-Prieto, Daniele Del Rio, Greg Drescher, Ramon Estruch, Chavanne Hanson, Timothy Harlan, Frank B. Hu, Maria Loi, James P. McClung, Angelo Mojica, Daniela Puglielli, Ken Toong, Fania Yangarber, Stefanos N. Kales. Mediterranean diet – promotion and dissemination of healthy eating: proceedings of an exploratory seminar at the Radcliffe institute for advanced study. International Journal of Food Sciences and Nutrition. 2021; ():1-14.

Chicago/Turabian Style

Mercedes Sotos-Prieto; Daniele Del Rio; Greg Drescher; Ramon Estruch; Chavanne Hanson; Timothy Harlan; Frank B. Hu; Maria Loi; James P. McClung; Angelo Mojica; Daniela Puglielli; Ken Toong; Fania Yangarber; Stefanos N. Kales. 2021. "Mediterranean diet – promotion and dissemination of healthy eating: proceedings of an exploratory seminar at the Radcliffe institute for advanced study." International Journal of Food Sciences and Nutrition , no. : 1-14.

Journal article
Published: 30 June 2021 in Nutrients
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The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women.

ACS Style

Marta Trius-Soler; María Marhuenda-Muñoz; Emily Laveriano-Santos; Miriam Martínez-Huélamo; Gemma Sasot; Carolina Storniolo; Ramon Estruch; Rosa Lamuela-Raventós; Anna Tresserra-Rimbau. Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women. Nutrients 2021, 13, 2278 .

AMA Style

Marta Trius-Soler, María Marhuenda-Muñoz, Emily Laveriano-Santos, Miriam Martínez-Huélamo, Gemma Sasot, Carolina Storniolo, Ramon Estruch, Rosa Lamuela-Raventós, Anna Tresserra-Rimbau. Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women. Nutrients. 2021; 13 (7):2278.

Chicago/Turabian Style

Marta Trius-Soler; María Marhuenda-Muñoz; Emily Laveriano-Santos; Miriam Martínez-Huélamo; Gemma Sasot; Carolina Storniolo; Ramon Estruch; Rosa Lamuela-Raventós; Anna Tresserra-Rimbau. 2021. "Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women." Nutrients 13, no. 7: 2278.

Journal article
Published: 02 June 2021 in Foods
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We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36–0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10–0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085–0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.

ACS Style

Álvaro Hernáez; Camille Lassale; Sara Castro-Barquero; Nancy Babio; Emilio Ros; Olga Castañer; Anna Tresserra-Rimbau; Xavier Pintó; Miguel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Ángel Alonso-Gómez; José Lapetra; Miquel Fiol; Enrique Gómez-Gracia; Lluis Serra-Majem; Emilio Sacanella; Ana García-Arellano; José Sorlí; Andrés Díaz-López; Montserrat Cofán; Ramón Estruch. Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial. Foods 2021, 10, 1268 .

AMA Style

Álvaro Hernáez, Camille Lassale, Sara Castro-Barquero, Nancy Babio, Emilio Ros, Olga Castañer, Anna Tresserra-Rimbau, Xavier Pintó, Miguel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Ángel Alonso-Gómez, José Lapetra, Miquel Fiol, Enrique Gómez-Gracia, Lluis Serra-Majem, Emilio Sacanella, Ana García-Arellano, José Sorlí, Andrés Díaz-López, Montserrat Cofán, Ramón Estruch. Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial. Foods. 2021; 10 (6):1268.

Chicago/Turabian Style

Álvaro Hernáez; Camille Lassale; Sara Castro-Barquero; Nancy Babio; Emilio Ros; Olga Castañer; Anna Tresserra-Rimbau; Xavier Pintó; Miguel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Ángel Alonso-Gómez; José Lapetra; Miquel Fiol; Enrique Gómez-Gracia; Lluis Serra-Majem; Emilio Sacanella; Ana García-Arellano; José Sorlí; Andrés Díaz-López; Montserrat Cofán; Ramón Estruch. 2021. "Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial." Foods 10, no. 6: 1268.

Dataset
Published: 22 May 2021
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ACS Style

Ramon Estruch; Rosa M. Casas. Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes. 2021, 1 .

AMA Style

Ramon Estruch, Rosa M. Casas. Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes. . 2021; ():1.

Chicago/Turabian Style

Ramon Estruch; Rosa M. Casas. 2021. "Assessing the effectiveness of the Greenhabit method (mHealth) for lifestyle modification in diabetes." , no. : 1.

Journal article
Published: 12 May 2021 in Nutrients
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Accuracy of dietary assessment instruments such as food frequency questionnaire (FFQ) is crucial in the evaluation of diet–disease relationships. Test–retest reliability and concurrent and construct validity of a FFQ were evaluated in 150 pregnant women at high risk to develop fetal growth restriction randomly selected from those included in the improving mothers for better prenatal care trial Barcelona (IMPACT BCN). The FFQ and dietary records were performed at baseline and 34–36 weeks of gestation. Test–retest reliability of the FFQ for 12 food groups and 17 nutrients was moderate (ICC = 0.55) and good (ICC = 0.60), respectively. Concurrent validity between food, nutrients and a composite Mediterranean diet score (MedDiet score) and food records was fair for foods and nutrients (ρ average = 0.38 and 0.32, respectively) and moderate (r = 0.46) for the MedDiet score. Validation with biological markers ranged from poor (r = 0.07) for olives to moderate (r = 0.41) for nuts. A fair concordance between methods were found for nutrients (weighted κ = 0.22) and foods (weighted κ = 0.27). The FFQ-derived MedDiet score correlated in anticipated directions with intakes of nutrients and foods derived by food records. The FFQ showed a moderate test–retest reliability and reasonable validity to rank women according to their food and nutrient consumption and adherence to the Mediterranean diet.

ACS Style

Charlotte Juton; Sara Castro-Barquero; Rosa Casas; Tania Freitas; Ana Ruiz-León; Francesca Crovetto; Mónica Domenech; Fátima Crispi; Eduard Vieta; Eduard Gratacós; Ramon Estruch; Helmut Schroder. Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction. Nutrients 2021, 13, 1629 .

AMA Style

Charlotte Juton, Sara Castro-Barquero, Rosa Casas, Tania Freitas, Ana Ruiz-León, Francesca Crovetto, Mónica Domenech, Fátima Crispi, Eduard Vieta, Eduard Gratacós, Ramon Estruch, Helmut Schroder. Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction. Nutrients. 2021; 13 (5):1629.

Chicago/Turabian Style

Charlotte Juton; Sara Castro-Barquero; Rosa Casas; Tania Freitas; Ana Ruiz-León; Francesca Crovetto; Mónica Domenech; Fátima Crispi; Eduard Vieta; Eduard Gratacós; Ramon Estruch; Helmut Schroder. 2021. "Reliability and Concurrent and Construct Validity of a Food Frequency Questionnaire for Pregnant Women at High Risk to Develop Fetal Growth Restriction." Nutrients 13, no. 5: 1629.

Brief report
Published: 11 May 2021 in Metabolites
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The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case–control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR for 1 SD increase: 1.28; 95% CI: 1.06, 1.53). The present findings do not support a role of the glycolysis pathway in the pathogenesis of AF. However, the increased risk of HF associated with phosphoglycerate requires further studies.

ACS Style

Nerea Becerra-Tomás; Miguel Ruiz-Canela; Pablo Hernández-Alonso; Mònica Bulló; Jun Li; Marta Guasch-Ferré; Estefanía Toledo; Clary Clish; Ramon Estruch; Emilio Ros; Montserrat Fitó; Chih-Hao Lee; Kerry Pierce; Fernando Arós; Lluís Serra-Majem; Liming Liang; Cristina Razquin; Enrique Gómez-Gracia; Miguel Martínez-González; Frank Hu; Dolores Corella; Jordi Salas-Salvadó. Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites 2021, 11, 306 .

AMA Style

Nerea Becerra-Tomás, Miguel Ruiz-Canela, Pablo Hernández-Alonso, Mònica Bulló, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Fernando Arós, Lluís Serra-Majem, Liming Liang, Cristina Razquin, Enrique Gómez-Gracia, Miguel Martínez-González, Frank Hu, Dolores Corella, Jordi Salas-Salvadó. Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites. 2021; 11 (5):306.

Chicago/Turabian Style

Nerea Becerra-Tomás; Miguel Ruiz-Canela; Pablo Hernández-Alonso; Mònica Bulló; Jun Li; Marta Guasch-Ferré; Estefanía Toledo; Clary Clish; Ramon Estruch; Emilio Ros; Montserrat Fitó; Chih-Hao Lee; Kerry Pierce; Fernando Arós; Lluís Serra-Majem; Liming Liang; Cristina Razquin; Enrique Gómez-Gracia; Miguel Martínez-González; Frank Hu; Dolores Corella; Jordi Salas-Salvadó. 2021. "Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial." Metabolites 11, no. 5: 306.

Journal article
Published: 04 May 2021 in Nutrients
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Clinical data on the direct health effects of energy deficit or surplus beyond its impact on body weight are scarce. We aimed to assess the association with all-cause, cardiovascular and cancer mortality of (1) sustained energy deficit or surplus, calculated according to each individual’s en-ergy intake (EI) and theoretical energy expenditure (TEE), and (2) mid-term change in total EI in a prospective study. In 7119 participants in the PREDIMED Study (PREvención con DIeta MEDi-terránea) with a mean age of 67 years, energy intake was derived from a 137-item food frequency questionnaire. TEE was calculated as a function of age, sex, height, body weight and physical ac-tivity. The main exposure was the proportion of energy requirement covered by energy intake, cumulative throughout the follow-up. The secondary exposure was the change in energy intake from baseline. Cox proportional hazard models were used to estimate hazard ratios and 95% con-fidence intervals for all-cause, cardiovascular and cancer mortality. Over a median follow-up of 4.8 years, there were 239 deaths (excluding the first 2 years). An energy intake exceeding energy needs was associated with an increase in mortality risk (continuous HR10% over energy needs = 1.10; 95% CI 1.02, 1.18), driven by cardiovascular death (HR = 1.26; 95% CI 1.11, 1.43). However, consum-ing energy below estimated needs was not associated with a lower risk. Increments over time in energy intake were associated with greater all-cause mortality (HR10% increase = 1.09; 95% CI 1.02, 1.17). However, there was no evidence that a substantial negative change in energy intake would reduce mortality risk. To conclude, in an older Mediterranean cohort, energy surplus or increase over a 5-year period was associated with greater risk of mortality, particularly cardiovascular mortality. Energy deficit, or reduction in energy intake over time were not associated with mortal-ity risk.

ACS Style

Camille Lassale; Álvaro Hernáez; Estefanía Toledo; Olga Castañer; José Sorlí; Jordi Salas-Salvadó; Ramon Estruch; Emilio Ros; Ángel Alonso-Gómez; José Lapetra; Raquel Cueto; Miquel Fiol; Lluis Serra-Majem; Xavier Pinto; Alfredo Gea; Dolores Corella; Nancy Babio; Montserrat Fitó; Helmut Schröder. Energy Balance and Risk of Mortality in Spanish Older Adults. Nutrients 2021, 13, 1545 .

AMA Style

Camille Lassale, Álvaro Hernáez, Estefanía Toledo, Olga Castañer, José Sorlí, Jordi Salas-Salvadó, Ramon Estruch, Emilio Ros, Ángel Alonso-Gómez, José Lapetra, Raquel Cueto, Miquel Fiol, Lluis Serra-Majem, Xavier Pinto, Alfredo Gea, Dolores Corella, Nancy Babio, Montserrat Fitó, Helmut Schröder. Energy Balance and Risk of Mortality in Spanish Older Adults. Nutrients. 2021; 13 (5):1545.

Chicago/Turabian Style

Camille Lassale; Álvaro Hernáez; Estefanía Toledo; Olga Castañer; José Sorlí; Jordi Salas-Salvadó; Ramon Estruch; Emilio Ros; Ángel Alonso-Gómez; José Lapetra; Raquel Cueto; Miquel Fiol; Lluis Serra-Majem; Xavier Pinto; Alfredo Gea; Dolores Corella; Nancy Babio; Montserrat Fitó; Helmut Schröder. 2021. "Energy Balance and Risk of Mortality in Spanish Older Adults." Nutrients 13, no. 5: 1545.

Journal article
Published: 30 March 2021 in Nutrients
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Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile.

ACS Style

Roque Pastor-Ibáñez; Juan Blanco-Heredia; Florencia Etcheverry; Sonsoles Sánchez-Palomino; Francisco Díez-Fuertes; Rosa Casas; María Navarrete-Muñoz; Sara Castro-Barquero; Constanza Lucero; Irene Fernández; Lorna Leal; José Benito; Marc Noguera-Julian; Roger Paredes; Norma Rallón; Ramón Estruch; David Torrents; Felipe García. Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals. Nutrients 2021, 13, 1141 .

AMA Style

Roque Pastor-Ibáñez, Juan Blanco-Heredia, Florencia Etcheverry, Sonsoles Sánchez-Palomino, Francisco Díez-Fuertes, Rosa Casas, María Navarrete-Muñoz, Sara Castro-Barquero, Constanza Lucero, Irene Fernández, Lorna Leal, José Benito, Marc Noguera-Julian, Roger Paredes, Norma Rallón, Ramón Estruch, David Torrents, Felipe García. Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals. Nutrients. 2021; 13 (4):1141.

Chicago/Turabian Style

Roque Pastor-Ibáñez; Juan Blanco-Heredia; Florencia Etcheverry; Sonsoles Sánchez-Palomino; Francisco Díez-Fuertes; Rosa Casas; María Navarrete-Muñoz; Sara Castro-Barquero; Constanza Lucero; Irene Fernández; Lorna Leal; José Benito; Marc Noguera-Julian; Roger Paredes; Norma Rallón; Ramón Estruch; David Torrents; Felipe García. 2021. "Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals." Nutrients 13, no. 4: 1141.

Journal article
Published: 17 March 2021 in Antioxidants
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Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 μmol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (−2.69 μmol/L (−5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high.

ACS Style

María Marhuenda-Muñoz; José Rinaldi de Alvarenga; Álvaro Hernáez; Anna Tresserra-Rimbau; Miguel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Mireia Malcampo; José Martínez; Ángel Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramón Estruch; Francisco Tinahones; José Lapetra; J. Serra-Majem; Aurora Bueno-Cavanillas; Josep Tur; Vicente Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Mercè Serra-Mir; Zenaida Vázquez-Ruiz; Stephanie Nishi; Jose Sorlí; María Zomeño; María Zulet; Jessica Vaquero-Luna; Rosa Carabaño-Moral; Leyre Notario-Barandiaran; Marga Morey; Antonio García-Ríos; Ana Gómez-Pérez; José Santos-Lozano; Pilar Buil-Cosiales; Josep Basora; Olga Portolés; Helmut Schröder; Itziar Abete; Itziar Salaverria-Lete; Estefanía Toledo; Nancy Babio; Montse Fitó; Miriam Martínez-Huélamo; Rosa Lamuela-Raventós. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma. Antioxidants 2021, 10, 473 .

AMA Style

María Marhuenda-Muñoz, José Rinaldi de Alvarenga, Álvaro Hernáez, Anna Tresserra-Rimbau, Miguel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Mireia Malcampo, José Martínez, Ángel Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramón Estruch, Francisco Tinahones, José Lapetra, J. Serra-Majem, Aurora Bueno-Cavanillas, Josep Tur, Vicente Sánchez, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Mercè Serra-Mir, Zenaida Vázquez-Ruiz, Stephanie Nishi, Jose Sorlí, María Zomeño, María Zulet, Jessica Vaquero-Luna, Rosa Carabaño-Moral, Leyre Notario-Barandiaran, Marga Morey, Antonio García-Ríos, Ana Gómez-Pérez, José Santos-Lozano, Pilar Buil-Cosiales, Josep Basora, Olga Portolés, Helmut Schröder, Itziar Abete, Itziar Salaverria-Lete, Estefanía Toledo, Nancy Babio, Montse Fitó, Miriam Martínez-Huélamo, Rosa Lamuela-Raventós. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma. Antioxidants. 2021; 10 (3):473.

Chicago/Turabian Style

María Marhuenda-Muñoz; José Rinaldi de Alvarenga; Álvaro Hernáez; Anna Tresserra-Rimbau; Miguel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Mireia Malcampo; José Martínez; Ángel Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramón Estruch; Francisco Tinahones; José Lapetra; J. Serra-Majem; Aurora Bueno-Cavanillas; Josep Tur; Vicente Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Mercè Serra-Mir; Zenaida Vázquez-Ruiz; Stephanie Nishi; Jose Sorlí; María Zomeño; María Zulet; Jessica Vaquero-Luna; Rosa Carabaño-Moral; Leyre Notario-Barandiaran; Marga Morey; Antonio García-Ríos; Ana Gómez-Pérez; José Santos-Lozano; Pilar Buil-Cosiales; Josep Basora; Olga Portolés; Helmut Schröder; Itziar Abete; Itziar Salaverria-Lete; Estefanía Toledo; Nancy Babio; Montse Fitó; Miriam Martínez-Huélamo; Rosa Lamuela-Raventós. 2021. "High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma." Antioxidants 10, no. 3: 473.

Review
Published: 09 March 2021 in Nutrients
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There is growing interest in the potential health-related effects of moderate alcohol consumption and, specifically, of beer. This review provides an assessment of beer-associated effects on cardiovascular and metabolic risk factors to identify a consumption level that can be considered “moderate”. We identified all prospective clinical studies and systematic reviews that evaluated the health effects of beer published between January 2007 and April 2020. Five of six selected studies found a protective effect of moderate alcohol drinking on cardiovascular disease (beer up to 385 g/week) vs. abstainers or occasional drinkers. Four out of five papers showed an association between moderate alcohol consumption (beer intake of 84 g alcohol/week) and decreased mortality risk. We concluded that moderate beer consumption of up to 16 g alcohol/day (1 drink/day) for women and 28 g/day (1–2 drinks/day) for men is associated with decreased incidence of cardiovascular disease and overall mortality, among other metabolic health benefits.

ACS Style

Ascensión Marcos; Lluís Serra-Majem; Francisco Pérez-Jiménez; Vicente Pascual; Francisco Tinahones; Ramón Estruch. Moderate Consumption of Beer and Its Effects on Cardiovascular and Metabolic Health: An Updated Review of Recent Scientific Evidence. Nutrients 2021, 13, 879 .

AMA Style

Ascensión Marcos, Lluís Serra-Majem, Francisco Pérez-Jiménez, Vicente Pascual, Francisco Tinahones, Ramón Estruch. Moderate Consumption of Beer and Its Effects on Cardiovascular and Metabolic Health: An Updated Review of Recent Scientific Evidence. Nutrients. 2021; 13 (3):879.

Chicago/Turabian Style

Ascensión Marcos; Lluís Serra-Majem; Francisco Pérez-Jiménez; Vicente Pascual; Francisco Tinahones; Ramón Estruch. 2021. "Moderate Consumption of Beer and Its Effects on Cardiovascular and Metabolic Health: An Updated Review of Recent Scientific Evidence." Nutrients 13, no. 3: 879.

Journal article
Published: 05 March 2021 in Antioxidants
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Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvención con DIeta MEDiterránea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71–0.80]), antihypertensive (HR: 0.79 [0.75–0.82]), statin (HR: 0.82 [0.78–0.85]), fibrate (HR: 0.78 [0.68–0.89]), antiplatelet (HR: 0.79 [0.75–0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74–0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56–0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180–360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.

ACS Style

Margarita Ribó-Coll; Sara Castro-Barquero; Camille Lassale; Emilio Sacanella; Emilio Ros; Estefanía Toledo; José Sorlí; Andrés Díaz-López; José Lapetra; Carlos Muñoz-Bravo; Fernando Arós; Miquel Fiol; Lluis Serra-Majem; Xavier Pinto; Olga Castañer; César Fernández-Lázaro; Olga Portolés; Nancy Babio; Ramón Estruch; Álvaro Hernáez. Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study. Antioxidants 2021, 10, 397 .

AMA Style

Margarita Ribó-Coll, Sara Castro-Barquero, Camille Lassale, Emilio Sacanella, Emilio Ros, Estefanía Toledo, José Sorlí, Andrés Díaz-López, José Lapetra, Carlos Muñoz-Bravo, Fernando Arós, Miquel Fiol, Lluis Serra-Majem, Xavier Pinto, Olga Castañer, César Fernández-Lázaro, Olga Portolés, Nancy Babio, Ramón Estruch, Álvaro Hernáez. Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study. Antioxidants. 2021; 10 (3):397.

Chicago/Turabian Style

Margarita Ribó-Coll; Sara Castro-Barquero; Camille Lassale; Emilio Sacanella; Emilio Ros; Estefanía Toledo; José Sorlí; Andrés Díaz-López; José Lapetra; Carlos Muñoz-Bravo; Fernando Arós; Miquel Fiol; Lluis Serra-Majem; Xavier Pinto; Olga Castañer; César Fernández-Lázaro; Olga Portolés; Nancy Babio; Ramón Estruch; Álvaro Hernáez. 2021. "Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study." Antioxidants 10, no. 3: 397.

Journal article
Published: 08 February 2021 in Nutrients
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There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.

ACS Style

Álvaro Hernáez; Camille Lassale; Sara Castro-Barquero; Emilio Ros; Anna Tresserra-Rimbau; Olga Castañer; Xavier Pintó; Zenaida Vázquez-Ruiz; José Sorlí; Jordi Salas-Salvadó; José Lapetra; Enrique Gómez-Gracia; Ángel Alonso-Gómez; Miquel Fiol; Lluis Serra-Majem; Emilio Sacanella; Cristina Razquin; Dolores Corella; Marta Guasch-Ferré; Montserrat Cofán; Ramón Estruch. Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial. Nutrients 2021, 13, 559 .

AMA Style

Álvaro Hernáez, Camille Lassale, Sara Castro-Barquero, Emilio Ros, Anna Tresserra-Rimbau, Olga Castañer, Xavier Pintó, Zenaida Vázquez-Ruiz, José Sorlí, Jordi Salas-Salvadó, José Lapetra, Enrique Gómez-Gracia, Ángel Alonso-Gómez, Miquel Fiol, Lluis Serra-Majem, Emilio Sacanella, Cristina Razquin, Dolores Corella, Marta Guasch-Ferré, Montserrat Cofán, Ramón Estruch. Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial. Nutrients. 2021; 13 (2):559.

Chicago/Turabian Style

Álvaro Hernáez; Camille Lassale; Sara Castro-Barquero; Emilio Ros; Anna Tresserra-Rimbau; Olga Castañer; Xavier Pintó; Zenaida Vázquez-Ruiz; José Sorlí; Jordi Salas-Salvadó; José Lapetra; Enrique Gómez-Gracia; Ángel Alonso-Gómez; Miquel Fiol; Lluis Serra-Majem; Emilio Sacanella; Cristina Razquin; Dolores Corella; Marta Guasch-Ferré; Montserrat Cofán; Ramón Estruch. 2021. "Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial." Nutrients 13, no. 2: 559.

Journal article
Published: 07 February 2021 in Nutrients
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Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence of gene-diet interactions on plasma adiponectin levels is still little understood. We analyzed the association between plasma adiponectin levels and various metabolic traits in a high-cardiovascular risk Mediterranean population, as well as the genetic effect of four candidate single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and their interactions with the Mediterranean dietary pattern. Additionally, we explored, at the genome-wide level, the SNPs most associated with plasma adiponectin levels, as well as gene–diet interactions with the Mediterranean diet. In the 954 participants studied (aged 55–80 years), plasma adiponectin levels were strongly associated with plasma HDL-C concentrations (p = 6.6 × 10−36) and inversely related to triglycerides (p = 4.7 × 10−18), fasting glucose (p = 3.5 × 10−16) and type 2 diabetes (p = 1.4 × 10−7). Of the four pre-selected ADIPOQ candidate SNPs, the one most associated with plasma adiponectin was the −11391G > A (rs17300539) promoter SNP (p = 7.2 × 10−5, in the multivariable adjusted model). No significant interactions with the Mediterranean diet pattern were observed for these SNPs. Additionally, in the exploratory genome-wide association study (GWAS), we found new SNPs associated with adiponectin concentrations at the suggestive genome-wide level (p < 1 × 10−5) for the whole population, including the lead SNP rs9738548 (intergenic) and rs11647294 in the VAT1L (Vesicle Amine Transport 1 Like) gene. We also found other promising SNPs on exploring different strata such as men, women, diabetics and non-diabetics (p = 3.5 × 10−8 for rs2850066). Similarly, we explored gene–Mediterranean diet interactions at the GWAS level and identified several SNPs with gene–diet interactions at p < 1 × 10−5. A remarkable gene–diet interaction was revealed for the rs2917570 SNP in the OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) gene, previously reported to be associated with adiponectin levels in some populations. Our results suggest that, in this high-cardiovascular risk Mediterranean population, and even though adiponectin is favorably associated with metabolic traits and lower type 2 diabetes, the gene variants more associated with adiponectin may be population-specific, and some suggestive gene–Mediterranean diet interactions were detected.

ACS Style

Oscar Coltell; Carolina Ortega-Azorín; Jose Sorlí; Olga Portolés; Eva Asensio; Carmen Saiz; Rocío Barragán; Ramon Estruch; Dolores Corella. Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects. Nutrients 2021, 13, 541 .

AMA Style

Oscar Coltell, Carolina Ortega-Azorín, Jose Sorlí, Olga Portolés, Eva Asensio, Carmen Saiz, Rocío Barragán, Ramon Estruch, Dolores Corella. Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects. Nutrients. 2021; 13 (2):541.

Chicago/Turabian Style

Oscar Coltell; Carolina Ortega-Azorín; Jose Sorlí; Olga Portolés; Eva Asensio; Carmen Saiz; Rocío Barragán; Ramon Estruch; Dolores Corella. 2021. "Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects." Nutrients 13, no. 2: 541.

Journal article
Published: 04 January 2021 in European Heart Journal
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This editorial refers to ‘Vegetarians, fish, poultry, and meat eaters: who has higher risk of cardiovascular disease incidence and mortality? A prospective study from the UK Biobank’, by F. Petermann-Rocha et al., doi:10.1093/eurheartj/ehaa939.

ACS Style

Ramon Estruch; Emilio Sacanella; Emilio Ros. Should we all go pesco-vegetarian? European Heart Journal 2021, 42, 1144 -1146.

AMA Style

Ramon Estruch, Emilio Sacanella, Emilio Ros. Should we all go pesco-vegetarian? European Heart Journal. 2021; 42 (12):1144-1146.

Chicago/Turabian Style

Ramon Estruch; Emilio Sacanella; Emilio Ros. 2021. "Should we all go pesco-vegetarian?" European Heart Journal 42, no. 12: 1144-1146.