Selecting an appropriate disc coulter is crucial for reducing the power consumption of no-till seeders, preventing straw from being pressed into seed furrows, improving the soil penetration performance of the disc coulter, and thus minimizing the weight of no-till seeders. This study utilized the quadratic regression orthogonal rotation central composite approach. With the application of EDEM and RecurDyn software, a virtual simulation model of the interaction between a toothed disc coulter and soil was developed. The angle of front serration δ, the angle of rear serration θ, and the number of serrations n were taken as experimental factors. The draft F_v and penetration resistance F_N were selected as performance evaluation indicators for parameter combination optimization simulation tests. The results indicated that δ, θ, and n have significant influences on F_v and F_N (p < 0.05). When the optimized parameter combinations δ, θ, and n were respectively determined as 16°, 39.1°, and 13, both F_v and F_N reached their minimum values. A comparative experimental study was conducted with the optimized toothed disc coulter and six existing disc coulters; under the working conditions of 14.4 km·h⁻¹, both the draft and penetration resistance of the toothed disc coulter are minimized. The draft was 227.5 ± 8.9 N and the penetration resistance was 415.9 ± 5.3 N. Meanwhile, the toothed disc coulter had the highest ratio of soil disturbance area to draft, indicating better soil loosening effects.