Background: The Olympic preparation of athletes has been highly influenced by COVID and post-COVID syndrome. As the complex screening of athletes is essential for safe and successful sports, we aimed to repeat the 2019-year sports cardiology screening of the Olympic Swim Team before the Olympics and to compare the results of COVID and non-COVID athletes. Methods: Patient history, electrocardiogram, laboratory tests, body composition analysis, echocardiography, cardiopulmonary exercise test (CPET) were performed. We used time-ranking points to compare swimming performance. Results: From April 2019, we examined 46 elite swimmers (24 ± 4 years). Fourteen swimmers had COVID infection; all cases were mild. During CPET there was no difference in the performance of COVID (male: VO₂ max 55 ± 4 vs. 56.5 ± 5 mL/kg/min, p = 0.53; female: VO₂ max 54.6 ± 4 vs. 56 ± 5.5 mL/kg/min, p = 0.86) vs. non-COVID athletes (male VO₂ max 56.7 ± 5 vs. 55.5 ± 4.5 mL/kg/min, p = 0.50; female 49.6 ± 3 vs. 50.7 ± 2.6 mL/kg/min, p = 0.47) between 2019 and 2021. When comparing the time results of the National Championships, 54.8% of the athletes showed an improvement (p = 0.75). Conclusions: COVID infection with short-term detraining did not affect the performance of well-trained swimmers. According to our results, the COVID pandemic did not impair the effectiveness of the preparation for the Tokyo Olympics.

Competitive athletes are often exposed to extreme physiological loading, resulting in over excessive mechanotransduction during their acute intensive training sessions and competitions. Individual differences in their genetics often affect how they cope with these challenges, as reflected in their high performances. Olympic Medalists are prohibited from providing atypical values in the Hematological Module of the Athlete Biological Passport. Since there was no aphysiological result and the Athlete maintained his innocence, a whole genome sequence analysis was carried out on him and his parents, with the primary focus on the PIEZO ion channels encoding gene. PIEZO1 is known to participate in homeostatic regulation even on a whole-body level, including the regulation of physical performance, circulatory longevity of red blood cells and cell fate determination of mesenchymal stem cells in relation to hydrostatic pressure. However, PIEZO2 was found to be the principal mechanosensory ion channel for proprioception. These regulatory mechanisms play a pivotal role in mechanotransduction and intensive exercise moments. Interestingly, two variances of uncertain significance of PIEZO1 were found that may explain the atypical values of the Athlete. Furthermore, two additional variances in SDC2, the syndcan-2 encoding gene, were identified in trans position that may influence the crosstalk between PIEZO2 and PIEZO1, with more likely relevance to the detected atypical values. After all, based on the found variances of PIEZO1 and syndecan-2, it cannot be ruled out that these VUS variants may have caused or impacted the exhibited outlier findings of the ABP Hematological Module of the Athlete.

Background: Research on the influence of the menstrual cycle on female athletic performance remains limited. This study investigated menstrual cycle characteristics, menstrual disorders, and phase-specific variations in perceived performance among female volleyball players. Methods: Eighty-four recreational and competitive athletes (M = 25.62 ± 6.43 years) completed a comprehensive survey between March and April 2025, including a modified Menstrual Distress Questionnaire (MEDI-Q) assessing physical and psychological well-being, perceived sport performance, training quality, and motivation across the menstrual, follicular, and luteal phases. Results: Perceived sport performance differed significantly across phases, with the highest scores in the follicular phase (M = 1.70 ± 1.51), followed by the luteal (M = 0.88 ± 1.13) and menstrual (M = 0.64 ± 1.00) phases (p < 0.001). Perceived performance impairments were greatest during menstruation and lowest in the follicular phase. Motivation exhibited a similar trend, peaking in the follicular (M = 1.74 ± 1.55) and declining during menstruation. Menstrual disorders were reported by 75% of participants, and 59.5% experienced dysmenorrhea. Knowledge scores (M = 11.13/18) indicated a moderate understanding of menstrual physiology. Conclusions: These findings demonstrate significant menstrual phase-related variations in subjective performance and motivation, emphasizing the importance of menstrual cycle awareness, athlete education, and individualized, phase-based training strategies to optimize performance and support female athlete welfare.