Pancreatic necrosis represents one of the most severe complications of acute pancreatitis (AP) and is linked to heightened risks of morbidity and mortality. Early recognition of this condition through simple and widely available biomarkers is particularly important in emergency departments, where immediate access to advanced imaging modalities may be limited. This study evaluated the diagnostic utility of the frontal QRS-T angle along with several inflammatory markers calculated from routine blood tests, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), for predicting the presence of pancreatic necrosis. This retrospective study included adult patients diagnosed with AP in the emergency department between September 2022 and September 2024. Exclusion criteria were applied, and 227 patients were analyzed. Electrocardiographic (ECG) and laboratory data obtained upon admission were compared between patients with and without radiologically confirmed necrosis. Receiver operating characteristic curve analysis and logistic regression models were used to determine the diagnostic performance and independent predictors of necrosis. Pancreatic necrosis was present in 50 patients (22.0%). The frontal QRS-T angle (F-QRS-T) was significantly higher in patients with necrosis (113.64 ± 45.41° vs 54.63 ± 36.27°, P < .001) and showed the strongest predictive performance (area under the curve (AUC) = 0.838, 95% confidence interval (CI): 0.784–0.884), with 58.0% sensitivity and 92.7% specificity at a cutoff of 105°. Inflammatory indices SII (AUC = 0.703), SIRI (AUC = 0.658), and AISI (AUC = 0.809) were also significantly elevated in the necrosis group. In multivariate analysis, the F-QRS-T remained the most significant independent predictor of necrosis (odds ratio = 1.039, 95% CI: 1.024–1.055, P < .001), along with C-reactive protein, SII, SIRI, and AISI. The F-QRS-T and inflammatory indices are promising early markers for predicting pancreatic necrosis in AP. Their utility is particularly valuable in peripheral or resource-limited settings where computed tomography imaging is not readily available or contrast use is contraindicated. Integration of these parameters into a standardized necrosis risk score may aid in timely intervention and improve patient outcomes. Further prospective research is required to confirm and strengthen these observations.

The COVID-19 pandemic exposed a structural limit of hospital isolation infrastructure: airborne infection isolation and protective-environment rooms are fixed assets that cannot be multiplied at the speed of a respiratory surge, and the constraint is more severe in field hospitals after disasters. Pandemic workarounds (ward conversion, portable negative-air machines, and modular container construction) each addressed part of the problem at the cost of bed capacity, sustained containment, or deployment speed. This concept paper aims to synthesize the failure modes of room-scale isolation into a device-agnostic set of clinical and engineering criteria for deployable bed-level single-patient isolation with switchable pressure polarity, in-enclosure air-quality monitoring, and on-board between-patient decontamination. These criteria are summarized in a requirements matrix, and one illustrative implementation is outlined. The intended contribution is a framework to guide future design, testing, and evaluation, not a validated solution; no validation data are presented, and none should be inferred.

Aim: The risk of stroke increases in patients developing transient ischemic attack (TIA) in the short term, and early initiation of treatment significantly reduces this risk. Therefore, serum biomarkers that confirm or exclude TIA will be very valuable in clinical practice. This study aimed to investigate the relationship between the Allopregnanolone (AP) levels of TIA patients. Methods: We conducted a prospective observational study of consecutive emergency department patients with TIA (December 2018–October 2019) and age/sex-matched healthy controls. Serum allopregnanolone (AP) was measured by ELISA at presentation and compared between groups, and diagnostic performance was assessed using ROC analysis. Results: 40 patients (17 women 42.5%, 23 men 57.5%) who met the inclusion criteria, and 40 healthy volunteers were included in the study. AP levels were found to be significantly higher in both men and women according to their gender compared to the control group (P<0.001). AP levels were significantly higher in the patients compared to the control group (197.04±32.15 vs. 128.75±12.66, p<0.001). The optimum cut-off value of AP in detecting TIA was determined as AUC: 0.740 (0.630-0.850), sensitivity: 70%, and specificity: 72.5% at 134.5. Conclusion: Our study demonstrates that serum allopregnanolone levels are significantly elevated in patients diagnosed with transient ischemic attack. These results, obtained from a controlled cohort with rigorous exclusion criteria, provide a foundation for future studies investigating the diagnostic role of neurosteroids in cerebrovascular events. How to cite this article: Şimşek A, Beceren NG, Armağan HH, Hatip AY, Yalçın İG, Oğuzlar FÇ, Bedel C. The role of allopregnanolone level in the diagnosis of the disease in transient ischemic attack patients. J Med Dent Invest 2025;6:e250135. https://doi.org/10.5577/jomdi.e250135

ObjectiveMean platelet volume (MPV) has been associatedwith thrombotic risk and acute coronary syndrome(ACS) severity in various clinical settings. However,data regarding its prognostic value in unstable angina(UA) patients presenting to the emergency department(ED) are limited. This study aimed to investigate therelationship between MPV measured at ED admissionand the angiographic severity of ACS, as quantified bythe Gensini score, in patients with UA. A secondaryobjective was to assess the predictive value of MPVfor all-cause mortality.Material and MethodThis retrospective cohort study included 203 patientsdiagnosed with ACS between July 2022 and July 2023.MPV and other laboratory parameters were recordedat the time of admission. Coronary angiographyfindings were evaluated using the Gensini scoringsystem. Data were analyzed based on Gensini scorecategories and mortality status.ResultsMPV values were significantly higher in patients withhigh Gensini scores and in those who experiencedmortality (p

To identify clinical, demographic, and MRI-based morphological factors associated with MRI-detected medial meniscus ramp lesions in patients with anterior