Artificial intelligence (AI) has rapidly evolved into a transformative force in radiology, complementing human intelligence across the entire imaging workflow. Current applications range from image acquisition and reconstruction to automated detection, quantification, triage, and clinical decision support. Evidence to date demonstrates that AI systems can match or exceed human performance in narrowly defined tasks, particularly in pattern recognition and workflow optimization. However, robust prospective validation, demonstration of clinical impact, and proof of generalizability across institutions and populations remain limited. Human intelligence continues to play a central role in contextual interpretation, integration of clinical information, ethical judgment, and responsibility for patient care. Rather than replacing radiologists, AI is increasingly viewed as an augmentative tool that enhances diagnostic accuracy, efficiency, and consistency when appropriately implemented. Regulatory frameworks are evolving in response to these developments. In Europe, the Medical Device Regulation (MDR) and the forthcoming AI Act introduce stricter requirements for transparency, risk classification, post-market surveillance, and human oversight. Comparable regulatory efforts are underway globally, aiming to balance innovation with patient safety, data protection, and accountability. Nonetheless, regulatory heterogeneity and the dynamic nature of adaptive AI systems pose ongoing challenges. Looking ahead, the future of radiology will be shaped by closer human–AI collaboration, increased emphasis on explainability, continuous learning systems under regulatory control, and higher-quality clinical evidence. Education and training of radiologists in AI literacy will be essential. Ultimately, the successful integration of artificial intelligence into radiology will depend not only on technological progress, but also on evidence-based implementation, clear regulation, and sustained human expertise. ----------------------------------------------------------------------------- Contents: 1. Introduction 2. Methods / Sources 3. Radiology Today: Clinical Role and Value Contribution 4. Radiation Protection as Culture (Technology, Behavior, Organization) 5. AI in Radiology: Application Areas and Evidence 6. Generative AI: Support Rather Than Replacement 7. Regulation, Governance, and Quality Assurance 8. Limits of Current Systems: “Common Sense” and Explainability 9. Outlook: Agentive Systems and Division of Labor 10. Practical Checklist: Governance & Safe Implementation 1. Introduction Artificial intelligence (AI) has rapidly evolved into a transformative force in radiology, complementing human intelligence across the entire imaging workflow. Current applications range from image acquisition and reconstruction to automated detection, quantification, triage, and clinical decision support. Evidence to date demonstrates that AI systems can match or exceed human performance in narrowly defined tasks, particularly in pattern recognition and workflow optimization. However, robust prospective validation, demonstration of clinical impact, and proof of generalizability across institutions and populations remain limited. Human intelligence continues to play a central role in contextual interpretation, integration of clinical information, ethical judgment, and responsibility for patient care. Rather than replacing radiologists, AI is increasingly viewed as an augmentative tool that enhances diagnostic accuracy, efficiency, and consistency when appropriately implemented. Regulatory frameworks are evolving in response to these developments. In Europe, the Medical Device Regulation (MDR) and the forthcoming AI Act introduce stricter requirements for transparency, risk classification, post-market surveillance, and human oversight. Comparable regulatory efforts are underway globally, aiming to balance innovation with patient safety, data protection, and accountability. Nonetheless, regulatory heterogeneity and the dynamic nature of adaptive AI systems pose ongoing challenges. Looking ahead, the future of radiology will be shaped by closer human–AI collaboration, increased emphasis on explainability, continuous learning systems under regulatory control, and higher-quality clinical evidence. Education and training of radiologists in AI literacy will be essential. Ultimately, the successful integration of artificial intelligence into radiology will depend not only on technological progress, but also on evidence-based implementation, clear regulation, and sustained human expertise. 2. Methods and Sources The present article is based on a curated, critical analysis of recent high-quality literature addressing the role of artificial intelligence (AI) in radiology. The purpose of this chapter is not to provide a systematic review in the strict methodological sense, but rather to transparently describe the sources used and to analyze how contemporary publications conceptualize, evaluate, and contextualize AI within clinical radiology. Emphasis is placed on methodological rigor, evidence generation, human–AI interaction, and regulatory framing. The selected time frame (2022–2025) captures a period that followed an initial phase of considerable enthusiasm surrounding AI in radiology. During the years preceding this interval, AI was frequently portrayed as a disruptive technology with the potential to fundamentally transform diagnostic imaging, often accompanied by claims of near-human or superhuman performance. More recent publications, however, reflect a noticeable shift toward a more cautious and sober assessment. This phase is characterized by increased attention to real-world performance, unintended consequences of AI deployment, limitations of retrospective evidence, and the growing influence of regulatory requirements (11). Against this background, the present analysis aims to examine how...