This study investigates whether C-reactive protein, platelet-lymphocyte ratio, and neutrophil-lymphocyte ratio could be useful to predict mortality in COVID-19. Data of 635 patients with COVID-19 followed up in Sinop Ataturk State Hospital from February to May 2020 were evaluated retrospectively. Diagnosis of COVID-19 was made according to the interim guidance of the World Health Organization. Patients were grouped into two groups based on mortality as survived and non-survived patients. Age, gender, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and C-reactive protein of the groups were investigated and compared. The mean age of the participants was 55.8±22.3 years. Among the patients, 584 survived and 51 patients died. Age was significantly different between the groups, 54.2±22.3 in the survived group and 75.6±11.1 in the dead group (p=0.000). In addition, neutrophil, C-reactive protein, and neutrophil-lymphocyte ratio values were significantly higher in the dead group (p=0.000). platelet-lymphocyte ratio was slightly higher in the dead group, but this difference was not significant (p=0.42). The area under the curve values for age, lymphocyte, platelet, C-reactive protein, and neutrophil-lymphocyte ratio are 0.797, 0.424, 0.485, 0.778, and 0.729, respectively. Our results showed that neutrophil-lymphocyte ratio and C-reactive protein are significantly higher in patients leading to death and could be effective biomarkers in predicting COVID-19 fatality. Furthermore, C-reactive protein could be used as an independent biomarker to predict death in patients with COVID-19, regardless of gender and age (p=0.000).

Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several antimicrobial drugs, including colistin. Colistin is a crucial antimicrobial agent in resistant A. baumannii infections. Colistin resistance varies between countries and regions worldwide. This study aimed to evaluate the studies on colistin resistance of A. baumannii strains in different regions of Turkey, show the increasing colistin resistance in years, and discuss the solution suggestions. Methods: The online electronic database was searched for studies evaluating the antibacterial efficacy of colistin combined with other antibiotics or alone in clinical samples of patients with A. baumannii infection. Results: In our study, colistin susceptibility was found to be between 81.8%-100% in Turkey. The lowest susceptibility to colistin for A. baumannii strains was reported in the Aegean Region (81.8-100%), followed by Black Sea (82.4-100%), Southeast Anatolia (94-96%), Central Anatolia (95.8-100), Marmara (96.8-100%), Mediterranean (98-100%), respectively, and the highest susceptibility was found in Eastern Anatolia Region (98.6-100%). According to the studies, a partial decrease in colistin sensitivity was found in some regions over the years and more decrease in others, but this decrease was not statistically significant (p> 0.05). The cities with the lowest colistin susceptibility were reported as İzmir 81.8%, Samsun 82.4%, Diyarbakır 94%, Düzce 94.1% and Ankara 95.8%. Conclusion: Colistin is still the most effective antimicrobial drug in A. baumannii infections. Our study concluded that there were some differences between regions and even within the same region in colistin susceptibility of A. baumannii in Turkey, and resistance development has increased over the years.

Objective:In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital. Methods:This retrospective study was performed in a multicenter study in April and October 2020. Demographic characteristics, clinical features, age, gender and length of stay of patients who exitus (EX) and were discharged due to COVID-19 were examined. Results:Of the patients (n:180) included in the study, 89 were female and 91 were male. There was a significant difference between the patients who were discharged from the hospital and died gender and complaints at the time of admission (p0.05). While the length of stay, platelet (PLT), mean corpuscular volume (MCV), serum C-reactive protein (CRP), albumin, lymphocyte, monocyte, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), ferritin, international normalized ratio, procalcitonin (PCT), troponin, and white blood cell counts are all increased in EX. There is a statistically significant difference in red blood cell distribution width (RDW) between EX and discharge patients (p0.05). While the RDW, monocyte/albumin, procalcitonin/albumin, CRP/albumin, LDH/albumin, and ürea/albumin ratios are increased in EX patients, the PCT/PLT and MPV/PLT ratios are increased in discharged patients. Conclusion: In this study, we demonstrated that hematological and biochemical markers may be utilized as an early prognostic indicator for patients identified with COVID-19.

Pandemic non-pharmaceutical interventions disrupted seasonal respiratory virus circulation, but longer-term pathogen-specific patterns in hospitalized adults remain incompletely defined. We evaluated detections across three nonconsecutive respiratory seasons from early relaxation of pandemic measures to five years after pandemic onset. This retrospective, observational, single-center cohort study included 2249 adults hospitalized with pneumonia, chronic obstructive pulmonary disease exacerbation, or asthma exacerbation who underwent multiplex polymerase chain reaction testing in September 2021–May 2022, September 2022–May 2023, or September 2025–May 2026. Influenza A positivity peaked in the second period (12.6%) and decreased to 6.8% in the third (p < 0.001). SARS-CoV-2 likewise peaked in the second period (9.2%) and declined to 1.5% in the third (p < 0.001). Respiratory syncytial virus increased from 0.5% in the first period to 4.9% and 3.8% in the second and third periods, respectively (p < 0.001). Positivity for other respiratory viruses did not differ (16.0%, 16.9%, and 19.1%; p = 0.308). Viral co-detection was highest in the second period (6.1% vs. 2.6% and 2.8%; p < 0.001). Respiratory virus epidemiology remained dynamic five years after pandemic onset, supporting sustained multi-pathogen surveillance.

Background Severe Plasmodium falciparum infection can present with life-threatening complications such as cerebral malaria and acute kidney injury, occasionally mimicking thrombotic thrombocytopenic purpura. Case presentation We report the case of a 45-year-old man who returned from Guinea without malaria prophylaxis. He presented with fever, vomiting, oliguria, and altered mental status. Peripheral blood smear revealed a parasitemia rate of 10%, with trophozoites and gametocytes of P. falciparum. Although initial findings suggested thrombotic thrombocytopenic purpura, the diagnosis was severe malaria with cerebral involvement and acute kidney injury. The patient was treated with intravenous artesunate and oral artemether-lumefantrine. Due to persistent anuria, multiple hemodialysis sessions were required. Neurological improvement was observed by day four, and parasitemia clearance was noted; however, dialysis continued for an additional two months. Renal function eventually normalized. Conclusions This report emphasizes the significance of travel history and blood smear examination in febrile patients with multi-organ dysfunction. Malaria prophylaxis remains critical for travelers to endemic areas.