Background: Oxidative stress plays a significant role in the progression of periodontal diseases. Hexagonal boron nitride (hBN) nanoparticles have antimicrobial, antiplaque, and antioxidant properties. The aim of this study to evaluate the protective and therapeutic effects of hBN against oxidative stress induced by hydrogen peroxide (H₂O₂) in human gingival fibroblast (HGF) cells. Methods: In this study, a primary cell line of HGFs was used. Oxidative stress was induced by treating the cells with 800 µM H₂O₂. hBN was applied at concentrations of 0.001, 0.005, and 0.01 mg/mL, either 2 h prior to or 2 h following H₂O₂ exposure. Cells were incubated for 24 h post-treatment. Cell viability was assessed using the 2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]-2 H-tetrazolium-5-carboxyanilide salt (XTT) assay. Additionally, the total oxidant status (TOS) was measured before and after oxidative damage at the 0.01 mg/mL hBN concentration. Results: hBN did not negatively affect cell viability in HGF cells at any concentration. The application of hBN to HGF cells before and after oxidative damage resulted in statistically significant (P < 0.001), albeit modest improvements in cell viability (2-5.5% and 3-6.5%, respectively). No significant differences were observed in TOS (P = 0.234), indicating that the cytoprotective effects were not mediated via alterations in TOS. Conclusions: Within the limitations of this in vitro study, hBN was found to enhance cell viability under H₂O₂-induced oxidative stress in HGF cells. These findings suggest a potential role for hBN in modulating antioxidant responses and supporting periodontal healing processes. However, their clinical relevance remains uncertain. Therefore, further mechanistic studies and clinical investigations are required to validate the potential adjunctive role of hBN in the prevention and treatment of periodontal diseases.

Background: Chlorhexidine is an antimicrobial used in many areas of dentistry. This study aims to assess publication trends and developments related to chlorhexidine, offering insights for future research. Methods: The bibliometric analysis on chlorhexidine covers the literature from 1980 to 2024. The data of our study were analyzed through the Bibliometrix program based on the WoS database. A total of 1,518 articles were examined in four sections: performance analysis, keyword analysis, co-citation analysis, and thematic analysis. Results: The Journal of Clinical Periodontology holds the highest H-Index (48) for chlorhexidine publications. Addy M. is the most prolific author, with 63 publications and 2,663 citations. His 1986 article has the highest local citation count. "Chlorhexidine" is the most frequent keyword. Prominent researchers include Loe H., Addy M., Lang NP, Flotra L., and Gjermo P., with a focus on periodontal diseases, plaque control, and antimicrobial efficacy. Coclusion: Chlorhexidine’s popularity in dentistry remains strong, with growing applications. This study highlights the current knowledge landscape and its limitations, serving as a guide for future research. Key Words: Clohexidine, Bibliometric Analysis, Co-Situation Analysis, Mouthrinse, Plaque

Amaç: Bu kesitsel retrospektif çalışmanın amacı, Bolu Abant İzzet Baysal Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalı öğrenci kliniğinde başlangıç periodontal tedavileri yapılan 1800 hastanın sistemik hastalık, periodontal durum ve kişisel alışkanlıklarının değerlendirilmesidir. Gereç ve Yöntemler: Çalışmaya dahil edilen bireylerin hasta formlarına kaydedilmiş olan demografik, dental şikayet ve sistemik durum bilgileri, sigara kullanımı, bruksizm ve ağız solunumu varlığı ile periodontal klinik parametreleri değerlendirildi. Bireyler periodontal durumlarına göre gingivitis (G), kronik periodontitis (KP) ve agresif periodontitis (AgP) olmak üzere üç gruba ayrıldı. Oluşturulan gruplar periodontal klinik parametreler (plak indeksi, gingival indeks, sondalamada kanama), sistemik hastalık (tip 2 diyabet, hipertansiyon ve kardiyovasküler hastalıklar gibi) ve kişisel alışkanlıklar açısından karşılaştırıldı. Verilerin istatistiksel analizleri SPSS 23.0 paket programı kullanılarak yapıldı. Bulgular: Çalışma popülasyonunun (%59.5’i kadın ve %40.5’i erkek) yaş ortalamasının 29.48±11.75 olduğu belirlendi. Hastaların %70.8’ine G, %28.7’sine KP ve %0.5’ine ise AgP teşhisi konulduğu saptandı. Erkek hastalarda sigara kullanımı prevalansının kadın hastalardan daha yüksek olduğu görüldü (p0.05); tiroid hastalıkları ve alerji durumunun kadınlarda erkeklere göre daha yüksek oranda olduğu tespit edildi (p

Aims: Furcation defects are considered one of the most complex and clinically significant challenges in periodontology, attracting sustained scientific interest. The aim of this study was to perform a comprehensive bibliometric analysis of publications on this topic, assess the temporal evolution of research, identify the most influential contributions, and highlight existing knowledge gaps and future research priorities. Methods: Using a predefined search strategy, a Web of Science (WoS) search was conducted on 07.05.2025. Articles were ranked by citation count and analyzed with the R-based Bibliometrix program across four categories: performance, vocabulary, collaboration, and thematic analysis. Results: Egelberg J is the most influential author in this field, with an H-index of 14 and 759 citations. The Journal of Clinical Periodontology and Journal of Periodontology are the leading sources, with the highest H-indexes (38 and 37, respectively) and citation counts (3.967 and 4.421, respectively). "Furcation defect" was the most frequently used keyword. The USA plays a central role in furcation defect research, collaborating closely with Brazil. The field of furcation defects is largely shaped by themes related to regenerative periodontology, biomaterials, advanced imaging technologies, and clinical surgical approaches. Conclusion: Furcation defects remain a major clinical challenge, underscoring the relevance of regenerative approaches supported by advances in biomaterials and imaging technologies. This bibliometric analysis provides an integrated overview of influential studies and emerging trends, offering guidance for future research.