Background and Objectives: Breast cancer remains one of the most common malignancies worldwide, and early detection plays a crucial role in improving treatment outcomes and reducing mortality. Several experimental studies using animal models of breast cancer have explored the potential of terahertz-based technologies in this field. However, their preclinical evidence base in breast cancer remains heterogeneous and has not been systematically synthesized with a focus on experimental models, imaging protocols, and barriers to translation. Methods: We conducted a descriptive systematic review, according to PRISMA guidelines, of 10 articles selected from a total of 372 identified across four databases—PubMed, Embase, Web of Science, and Cochrane—regarding the diagnostic performance of terahertz (THz) imaging in breast cancer animal models. We included studies that used rodent models diagnosed with breast cancer, subsequently confirmed through histological examination, and extracted relevant data. Results: The results were synthesized using a narrative approach. Most studies used C57BL/6J mice with E0771 cell line-induced breast tumors, with histopathology as the reference standard. In the reflection mode, at frequencies between 0.1 and 4 THz, the identification of tumoral, fibrous, fat, and muscle tissues was possible. Conclusions: Overall, the available preclinical evidence supports THz imaging as a promising proof-of-concept approach for breast tissue characterization, but not yet as a standardized or clinically translatable diagnostic platform. Future studies should use harmonized animal models, standardized acquisition and specimen-handling protocols, transparent reporting of classification workflows, and consistent outcome metrics to enable comparison across studies and to clarify the biological and biophysical determinants of THz contrast in breast cancer.

Background/Objectives: Adolescent pregnancy, defined as pregnancy occurring between ages 10 and 19, remains a pressing global health concern with significant disparities in prevalence and outcomes across countries. Early and systematic diagnostic screening may allow timely risk stratification and adequate management. Methods: We conducted this retrospective cohort study at a tertiary referral center from January 2015 through December 2024, including all women who delivered live fetuses at our facility, analyzing adolescent pregnancy outcomes in our region and comparing them with adult pregnancy outcomes. Results: Younger adolescents have higher rates of vaginal infections (45.3% vs. 38.1%), chorioamnionitis, urinary tract infections (6% vs. 4.9%), preterm birth, higher cesarean section rates, SGA and FGR fetuses, with more frequent NICU admissions than older adolescents. Adolescent pregnancies more often resulted in vaginal births compared to adult pregnancies but also showed higher rates of operative vaginal delivery, episiotomy, perineal tears, vaginal tears, and cervical lacerations. Gestational diabetes and excessive gestational weight gain were overall less common in adolescents, but pre-pregnancy maternal obesity was significantly more prevalent in the older adolescent group than in the younger ones. Gestational hypertension was about twice as frequent in adult pregnancies, while HELLP syndrome was approximately six times more common in adults than in adolescents. Conclusions: In summary, adolescent pregnancy presents both potential biological advantages and notable disadvantages, with outcomes resulting from the complex interplay of biological immaturity and socioeconomic factors. These results highlight the critical importance of implementing comprehensive early diagnostic screening protocols and structured antenatal care to facilitate earlier identification and mitigation of modifiable risk factors to improve both maternal and fetal outcomes.

Background/Objectives: Surgical management of postpartum hemorrhage (PPH) is essential when conservative measures fail, yet no clear hierarchy of effectiveness among interventions exists. Given the scarcity of the direct comparative studies and the substantial clinical and methodological heterogenicity of the available evidence, this systematic review aims to provide an updated and structured synthesis of the UCS for the management of refractory PPH. Methods: We reviewed studies published from January 2014 to December 2025 using keywords related to PPH and UCS. After excluding duplicates and applying the inclusion and exclusion criteria, we selected 31 articles. Results: We grouped the selected articles into 4 sections: UCS alone; UCS versus uterine artery embolization (UAE) and versus Bakri balloon tamponade; newer UCS techniques; and articles on future fertility outcomes after UCS. Evidence on UCS alone was predominantly uncontrolled observational case series, with reported efficacy ranging from 73.9% to 100%. Newer UCS techniques use removable sutures to reduce side effects and complications. Although early results on subsequent fertility and menstrual function appear promising, the lack of large, well-designed randomized studies warrants caution in interpretation. Conclusions: Asian tertiary centers dominate the literature and report high uterine preservation rates, but retrospective design, small samples, lack of controls, inadequate adjustment for confounders, and heterogeneous techniques limit the strength of conclusions and generalizability. The predominance of cesarean section cohort further limits generalizability to vaginal births. UCS efficacy appears strongly influenced by bleeding severity and case complexity.