Background and Aims. Fatigue is an unpleasant experience accompanied by functional deterioration involving both mental and physical factors. Caregivers of patients with severe illnesses who require long-term treatment often experience marked physical and mental fatigue. This study investigated the factors affecting fatigue among caregivers of patients with severe chronic diseases. Methods. The study enrolled 100 caregivers of patients providing home care nursing at a university hospital in Gyeonggi-do of Korea, including 47 caregivers caring for cancer patients and 53 caregivers caring for chronic disease patients (e.g., dementia, amyotrophic lateral sclerosis, and Parkinson’s disease). The degree of fatigue was measured using the Korean version of the multidimensional fatigue inventory (MFI-K). Caregiver depression and anxiety were examined using the Hospital Anxiety and Depression Scale. Results. The average MFI-K score of all caregivers was 60.43 ± 13.77 and did not differ significantly between those caring for cancer patients and those caring for patients with severe chronic diseases (62.15 ± 13.27 vs. 58.49 ± 14.20, respectively, p=0.186). The longer the disease duration, the greater the general and physical fatigue of the caregiver (r = 0.284, p=0.004). However, caregiver mental fatigue did not differ according to disease duration (r = 0.169, p=0.094). The main factors affecting caregiver general and physical fatigue were caregiver anxiety and depression and patient’s disease duration. Conclusions. The caregivers of patients with cancer or chronic severe illnesses experience high levels of fatigue: the longer the disease duration, the greater the degrees of depression, anxiety, and physical fatigue experienced by the caregivers. Such caregivers need strategies to manage their fatigue and depression.

Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear. The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders. Retrospective study. Health Promotion Center of the University Hospital (Gyeonggi-do, South Korea), during the period 2010-2014. Participants were enrolled from the general population who visited for a medical check-up. CAC was assessed in asymptomatic individuals by multidetector computed tomography. Anthropometric parameters and metabolic profiles were also recorded. Subjects were divided into four fasting glucose groups. Participants with a history of CVD or diabetes mellitus were excluded. Correlation between FPG and CAC scores, CAC score categories, and association between CAC score and FPG categories. Of 1112 participants, 346 (34.2%) had a CAC score > 0. FPG values in the IFG patients were positively but weakly correlated with CAC scores (r=0.099, P=.001). The incidence of CAC differed according to FPG level (P < .001) and in Kruskal-Wallis test the mean CAC score differed by FPG group (P < .001). After adjustment for other factors in a multiple logistic regression analysis, those subjects with FPG >=110 mg/dL had a significantly higher risk of CAC than did subjects with normal fasting glucose (110.

Obesity is a risk factor for cardiovascular disease, but metabolic disturbances can also lead to the development of this disease. Therefore, we investigated the associations between obesity subtype, considering both body weight and metabolic disturbances, and carotid atherosclerosis as a predictor of cardiovascular disease in Korean men. Data from a total of 980 men were analysed in this study. Obesity subtypes were classified as normal weight without metabolic syndrome (metabolically healthy normal weight; MHNW), obesity without metabolic syndrome (metabolically healthy, but obese; MHO), normal weight with metabolic syndrome (metabolically abnormal, but normal weight; MANW) and obesity with metabolic syndrome (metabolically abnormal obese; MAO). Carotid intima-media thickness (CIMT) and carotid plaque were assessed using a high-resolution B-mode ultrasound system. Carotid atherosclerosis was defined as a mean CIMT value >0.9 mm or the presence of carotid plaque. Mean CIMT in the MAO subtype was significantly higher than that in the MHNW control group (0.790 ± 0.019 vs. 0.747 ± 0.013 mm; p < 0.001). The presence of carotid plaque was positively associated with MAO subtype [adjusted odds ratio (aOR) 1.49, 95 % confidence interval (CI) 1.02–2.16; p = 0.039], but not with MHO or MANW, compared to the MHNW control group. The MAO subtype showed a positive association with the presence of carotid atherosclerosis (aOR 1.68, 95 % CI 1.17–2.42; p = 0.006). Only the MAO subtype showed a higher CIMT value and positive associations with carotid plaque and carotid atherosclerosis, but not with MHO and MANW subtypes, compared to the MHNW control. Additional prospective studies are needed to evaluate preclinical carotid atherosclerosis according to the subtypes of obesity.