Introduction. Molnupiravir is an orally administered antiviral agent approved for the treatment patients with mild to moderate coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. Its antiviral effect is based on the inhibition of viral replication. The aim of this study was to evaluate the effectiveness and safety of molnupiravir in clinical practice. Material and Methods. This retrospective study included 74 non-hospitalized patients with mild to moderate clinical presentation who were treated with molnupiravir at the Covid Hospital of the University Clinical Center of Vojvodina during 2022. Treatment efficacy was assessed based on the occurrence of hospitalization or death within 28 days after therapy initiation. Results. Disease progression requiring hospitalization occurred in 4 of 74 patients (5.4%). No deaths were recorded during the 28-day follow-up. Molnupiravir treatment was not associated with a significant reduction in viral load by day 5 of therapy. Conclusion. When administered within the first three days after symptom onset, molnupiravir appears to reduce the risk of hospitalization and mortality.

Background and Objectives: Sepsis is a life-threatening organ dysfunction, and specific biomarkers could improve prognostic assessment in septic patients. The Sequential Organ Failure Assessment (SOFA) score is the standard tool for clinical sepsis monitoring. Recent studies highlight the need for its revision and the identification of rapid, specific, sensitive predictors of sepsis mortality. The aim of this study was to determine the significance of cardiac biomarkers alone or combined with the SOFA score for evaluating sepsis-related mortality. Materials and Methods: This is a retrospective, single-center study with a relatively small sample size of 73 septic patients (Sepsis-3 criteria) hospitalized in an intensive care unit (ICU) and intermediate care unit (IMCU). All patients had standard laboratory parameters, cardiac biomarkers, and the SOFA score available upon admission. Statistical analyses included non-parametric Mann–Whitney U test, ROC (Receiver Operating Characteristic) curve analysis, Hanley & McNeil method and Hosmer–Lemeshow goodness-of-fit test. Results: Lactate (p < 0.001) and SOFA (p < 0.001) showed the highest area under the curve (AUC) values, and all cardiac biomarkers had statistically significant AUCs (p < 0.05) for sepsis mortality prediction. A comparison of all ROC curves was conducted, but no statistically significant differences were observed. Adding hs-cTn (high-sensitivity cardiac troponin) and lactate to the SOFA score increased its AUC from 0.767 to 0.827 (p = 0.421). Conclusions: The results showed that non-survivors of sepsis had significantly higher levels of cardiac biomarkers compared to survivors. There were no statistically significant differences in the areas under the ROC curves among the three markers, or between the markers and SOFA. The addition of cardiac biomarkers to SOFA did not improve the discriminatory ability of the SOFA score. Further research with a larger sample size is required to validate and generalize the findings.

Background and Objectives: Sepsis is a life-threatening organ dysfunction, and specific biomarkers could improve prognostic assessment in septic patients. The Sequential Organ Failure Assessment (SOFA) score is the standard tool for clinical sepsis monitoring. Recent studies highlight the need for its revision and the identification of rapid, specific, sensitive predictors of sepsis mortality. The aim of this study was to determine the significance of cardiac biomarkers alone or combined with the SOFA score for evaluating sepsis-related mortality. Materials and Methods: This is a retrospective, single-center study with a relatively small sample size of 73 septic patients (Sepsis-3 criteria) hospitalized in an intensive care unit (ICU) and intermediate care unit (IMCU). All patients had standard laboratory parameters, cardiac biomarkers, and the SOFA score available upon admission. Statistical analyses included non-parametric Mann–Whitney U test, ROC (Receiver Operating Characteristic) curve analysis, Hanley & McNeil method and Hosmer–Lemeshow goodness-of-fit test. Results: Lactate (p < 0.001) and SOFA (p < 0.001) showed the highest area under the curve (AUC) values, and all cardiac biomarkers had statistically significant AUCs (p < 0.05) for sepsis mortality prediction. A comparison of all ROC curves was conducted, but no statistically significant differences were observed. Adding hs-cTn (high-sensitivity cardiac troponin) and lactate to the SOFA score increased its AUC from 0.767 to 0.827 (p = 0.421). Conclusions: The results highlight the potential role of cardiac biomarkers alone or in combination with the SOFA score as useful clinical tool for predicting sepsis mortality. Further research with a larger sample size is required to validate and generalize the findings.