François Villeret

Dr. François Villeret

orcid

Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 June 2026 in Liver International
Verified
Journal Article
Open access
PDF file
IBIsaure Bienvenue
Isaure Bienvenue
OROlivier Roux
Olivier Roux
ACAudrey Coilly
Audrey Coilly
AAArmand Abergel
Armand Abergel
TATeresa Antonini
Teresa Antonini
FVFrançois Villeret
François Villeret
Background & Aims: Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed to describe and evaluate patient survival after LT for HBV‐related disease in France and identify the factors influencing survival. Methods: The present retrospective cohort study based on medical record information included all adult patients transplanted with positive HBsAg (+/− coinfection with Hepatitis D virus (HDV)) between January 1, 2005 and December 31, 2023 in all French LT centres. Results: The study population consisted of 1083 patients, the majority of whom were men (81.5%) with a median [IQR] age at LT listing of 52.8 [42.5–59.8] years. Indications for LT were HBV‐related HCC (47.2%), HBV‐related cirrhosis (28.5%), HDV‐related cirrhosis (11.2%), HBV‐related ALF (10.5%), HDV‐related HCC (1.4%) and other (0.7%). Median [IQR] post‐LT follow‐up was 6.0 [2.2–11.1] years. Patient survival at 1, 5, 10 and 15 years after LT was 91.6%, 80.1%, 71.8% and 63.6% respectively. Multivariate analysis showed that independent significant prognostic factors were age at LT (HR: 1.030; 95CI: 1.019–1.042; p < 0.0001) and the pre‐LT nucleos(t)ides analogue (NUC) regimen: in comparison to tenofovir, the use of entecavir alone (HR: 1.735; 95CI: 1.312–2.295; p < 0.0001) or another NUC or combination therapy (HR: 1.471; 95CI: 1.059–2.043; p = 0.021) were associated with decreased survival. Conclusions: Survival after LT for HBV‐related liver disease is good. NUC type prior to LT seems to be associated with patient survival.